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{{For|the journal|Neuroscience (journal)}}{{Redirect|Brain science|other aspects of brain science|cognitive science|and|cognitive psychology|and|neurology|and|neuropsychology}}File:PurkinjeCell.jpg|right|thumb|250px|Drawing by Santiago Ramón y Cajal (1899) of neuronneuron{{short description | scientific study of the nervous system}}Neuroscience (or neurobiology) is the scientific study of the nervous system.WEB, Neuroscience, Merriam-Webster Medical Dictionary,weblink It is a multidisciplinary branch of biologyWEB,weblink Neurobiology, Dictionary.com, 2017-01-22, that combines physiology, anatomy, molecular biology, developmental biology, cytology, mathematical modeling and psychology to understand the fundamental and emergent properties of neurons and neural circuits.BOOK, Principles of Neural Science, Fifth Edition, Kandel, Eric R., McGraw-Hill Education, 2012, 978-0071390118, I. Overall perspective, BOOK,weblink Lexicon of Psychiatry, Neurology and the Neurosciences, Ayd, Frank J., Jr., 2000, Lippincott, Williams & Wilkins, 978-0781724685, 688, BOOK,weblink Brain Imaging: What it Can (and Cannot) Tell Us About Consciousness, Shulman, Robert G., 2013, Oxford University Press, 9780199838721, 59, Neuroscience: A Multidisciplinary, Multilevel Field, BOOK,weblink Methods in Neuroethological Research, Ogawa, Hiroto, Oka, Kotaro, 2013, Springer, 9784431543305, v, JOURNAL, Tanner, Kimberly D., 2006-01-01, Issues in Neuroscience Education: Making Connections, CBE— Life Sciences Education, 5, 2, 85, 10.1187/cbe.06-04-0156, 1931-7913, 1618510, The understanding of the biological basis of learning, memory, behavior, perception, and consciousness has been described by Eric Kandel as the "ultimate challenge" of the biological sciences.BOOK, Principles of Neural Science, Fifth Edition, Kandel, Eric R., McGraw-Hill Education, 2012, 978-0071390118, 5, The last frontier of the biological sciences – their ultimate challenge – is to understand the biological basis of consciousness and the mental processes by which we perceive, act, learn, and remember., The scope of neuroscience has broadened over time to include different approaches used to study the nervous system at different scales and the techniques used by neuroscientists have expanded enormously, from molecular and cellular studies of individual neurons to imaging of sensory, motor and cognitive tasks in the brain.

History

File:Gray739.png|right|thumb|250px|Illustration from Gray's Anatomy (1918) of a lateral view of the human brain, featuring the hippocampushippocampusThe earliest study of the nervous system dates to ancient Egypt. Trepanation, the surgical practice of either drilling or scraping a hole into the skull for the purpose of curing head injuries or mental disorders, or relieving cranial pressure, was first recorded during the Neolithic period. Manuscripts dating to 1700 BC indicate that the Egyptians had some knowledge about symptoms of brain damage.WEB, Mohamed W, 2008, The Edwin Smith Surgical Papyrus: Neuroscience in Ancient Egypt, IBRO History of Neuroscience,weblink 2014-07-06, Early views on the function of the brain regarded it to be a "cranial stuffing" of sorts. In Egypt, from the late Middle Kingdom onwards, the brain was regularly removed in preparation for mummification. It was believed at the time that the heart was the seat of intelligence. According to Herodotus, the first step of mummification was to "take a crooked piece of iron, and with it draw out the brain through the nostrils, thus getting rid of a portion, while the skull is cleared of the rest by rinsing with drugs."BOOK, Herodotus, George Rawlinson, 2009, 440 BCE, The Histories: Book II (Euterpe),weblink The view that the heart was the source of consciousness was not challenged until the time of the Greek physician Hippocrates. He believed that the brain was not only involved with sensation—since most specialized organs (e.g., eyes, ears, tongue) are located in the head near the brain—but was also the seat of intelligence. Plato also speculated that the brain was the seat of the rational part of the soul.BOOK, Plato, George Rawlinson, 2009, 360 BCE, Timaeus,weblink Aristotle, however, believed the heart was the center of intelligence and that the brain regulated the amount of heat from the heart.BOOK, Finger, Stanley, Origins of Neuroscience: A History of Explorations into Brain Function, 3rd, Oxford University Press, USA, New York, 2001, 978-0-19-514694-3, 3–17, This view was generally accepted until the Roman physician Galen, a follower of Hippocrates and physician to Roman gladiators, observed that his patients lost their mental faculties when they had sustained damage to their brains.Abulcasis, Averroes, Avicenna, Avenzoar, and Maimonides, active in the Medieval Muslim world, described a number of medical problems related to the brain. In Renaissance Europe, Vesalius (1514–1564), René Descartes (1596–1650), Thomas Willis (1621–1675) and Jan Swammerdam (1637–1680) also made several contributions to neuroscience.
missing image!
- GolgiStainedPyramidalCell.jpg -
The Golgi stain first allowed for the visualization of individual neurons.
Luigi Galvani's pioneering work in the late 1700s set the stage for studying the electrical excitability of muscles and neurons. In the first half of the 19th century, Jean Pierre Flourens pioneered the experimental method of carrying out localized lesions of the brain in living animals describing their effects on motricity, sensibility and behavior. In 1843 Emil du Bois-Reymond demonstrated the electrical nature of the nerve signal,BOOK, Emil du Bois-Reymond: Neuroscience, Self, and Society in Nineteenth-Century Germany, Finkelstein, Gabriel, The MIT Press, 2013, 9780262019507, Cambridge; London, 72–74, 89–95, whose speed Hermann von Helmholtz proceeded to measure,BOOK, Harrison, David W., Brain Asymmetry and Neural Systems Foundations in Clinical Neuroscience and Neuropsychology, 2015, Springer International Publishing, 978-3-319-13068-2, 15–16, and in 1875 Richard Caton found electrical phenomena in the cerebral hemispheres of rabbits and monkeys.WEB,weblink Caton, Richard - The electric currents of the brain, echo.mpiwg-berlin.mpg.de, 2018-12-21, Adolf Beck published in 1890 similar observations of spontaneous electrical activity of the brain of rabbits and dogs.JOURNAL, Coenen, Anton, Edward Fine, Oksana Zayachkivska, Adolf Beck: A Forgotten Pioneer In Electroencephalography, Journal of the History of the Neurosciences, 23, 3, 2014, 276–286, 10.1080/0964704x.2013.867600, 24735457, Studies of the brain became more sophisticated after the invention of the microscope and the development of a staining procedure by Camillo Golgi during the late 1890s. The procedure used a silver chromate salt to reveal the intricate structures of individual neurons. His technique was used by Santiago Ramón y Cajal and led to the formation of the neuron doctrine, the hypothesis that the functional unit of the brain is the neuron.JOURNAL, Guillery, R, Observations of synaptic structures: origins of the neuron doctrine and its current status, 1569502, 16147523, 10.1098/rstb.2003.1459, 360, 1458, Jun 2005, Philos Trans R Soc Lond B Biol Sci, 1281–307, Golgi and Ramón y Cajal shared the Nobel Prize in Physiology or Medicine in 1906 for their extensive observations, descriptions, and categorizations of neurons throughout the brain.In parallel with this research, work with brain-damaged patients by Paul Broca suggested that certain regions of the brain were responsible for certain functions. At the time, Broca's findings were seen as a confirmation of Franz Joseph Gall's theory that language was localized and that certain psychological functions were localized in specific areas of the cerebral cortex.JOURNAL, Greenblatt SH, 1995, Phrenology in the science and culture of the 19th century, Neurosurgery, 37, 4, 790–805, 8559310, 10.1227/00006123-199510000-00025, BOOK, Bear MF, Connors BW, Paradiso MA, 2001, Neuroscience: Exploring the Brain, 2nd, Lippincott Williams & Wilkins, Philadelphia, 978-0-7817-3944-3, The localization of function hypothesis was supported by observations of epileptic patients conducted by John Hughlings Jackson, who correctly inferred the organization of the motor cortex by watching the progression of seizures through the body. Carl Wernicke further developed the theory of the specialization of specific brain structures in language comprehension and production. Modern research through neuroimaging techniques, still uses the Brodmann cerebral cytoarchitectonic map (referring to study of cell structure) anatomical definitions from this era in continuing to show that distinct areas of the cortex are activated in the execution of specific tasks.BOOK, Kandel ER, Schwartz JH, Jessel TM, 2000, Principles of Neural Science, 4th, McGraw-Hill, New York, 978-0-8385-7701-1, Principles of Neural Science, During the 20th century, neuroscience began to be recognized as a distinct academic discipline in its own right, rather than as studies of the nervous system within other disciplines. Eric Kandel and collaborators have cited David Rioch, Francis O. Schmitt, and Stephen Kuffler as having played critical roles in establishing the field.JOURNAL, Cowan, W.M., Harter, D.H., Kandel, E.R., 2000, The emergence of modern neuroscience: Some implications for neurology and psychiatry, Annual Review of Neuroscience, 23, 345–346, 10.1146/annurev.neuro.23.1.343, 10845068, Rioch originated the integration of basic anatomical and physiological research with clinical psychiatry at the Walter Reed Army Institute of Research, starting in the 1950s. During the same period, Schmitt established a neuroscience research program within the Biology Department at the Massachusetts Institute of Technology, bringing together biology, chemistry, physics, and mathematics. The first freestanding neuroscience department (then called Psychobiology) was founded in 1964 at the University of California, Irvine by James L. McGaugh.BOOK, The history of neuroscience in autobiography, 1996, Volume, Society for Neuroscience, Squire, Larry R., Society for Neuroscience., 0916110516, 4, Washington DC, 410, James McGaugh, 36433905,weblink This was followed by the Department of Neurobiology at Harvard Medical School, which was founded in 1966 by Stephen Kuffler.WEB, History - Department of Neurobiology,weblink The understanding of neurons and of nervous system function became increasingly precise and molecular during the 20th century. For example, in 1952, Alan Lloyd Hodgkin and Andrew Huxley presented a mathematical model for transmission of electrical signals in neurons of the giant axon of a squid, which they called "action potentials", and how they are initiated and propagated, known as the Hodgkin–Huxley model. In 1961–1962, Richard FitzHugh and J. Nagumo simplified Hodgkin–Huxley, in what is called the FitzHugh–Nagumo model. In 1962, Bernard Katz modeled neurotransmission across the space between neurons known as synapses. Beginning in 1966, Eric Kandel and collaborators examined biochemical changes in neurons associated with learning and memory storage in Aplysia. In 1981 Catherine Morris and Harold Lecar combined these models in the Morris–Lecar model. Such increasingly quantitative work gave rise to numerous biological neuron models and models of neural computation.As a result of the increasing interest about the nervous system, several prominent neuroscience organizations have been formed to provide a forum to all neuroscientist during the 20th century. For example, the International Brain Research Organization was founded in 1961,WEB,weblink History of IBRO, 2010, International Brain Research Organization, {{cbignore|bot=medic}} the International Society for Neurochemistry in 1963,The Beginning {{webarchive|url=https://web.archive.org/web/20120421033642weblink|date=April 21, 2012}}, International Society for Neurochemistry the European Brain and Behaviour Society in 1968,WEB,weblink About EBBS, 2009, European Brain and Behaviour Society,weblink" title="web.archive.org/web/20160303235558weblink">weblink 2016-03-03, yes, and the Society for Neuroscience in 1969.WEB,weblink About SfN, Society for Neuroscience, Recently, the application of neuroscience research results has also given rise to applied disciplines as neuroeconomics,JOURNAL, How can neuroscience inform economics?,weblink Current Opinion in Behavioral Sciences, neuroeducation,Zull, J. (2002). The art of changing the brain: Enriching the practice of teaching by exploring the biology of learning. Sterling, Virginia: Stylus Publishing, LLC neuroethics,WEB,weblink What is Neuroethics?, www.neuroethicssociety.org, 2019-02-22, and neurolaw.JOURNAL, Petoft, Arian, 2015-01-05, Neurolaw: A brief introduction, Iranian Journal of Neurology, 14, 1, 53–58, 2008-384X, 4395810, 25874060, Over time, brain research has gone through philosophical, experimental, and theoretical phases, with work on brain simulation predicted to be important in the future.JOURNAL, Fan, Xue, Markram, Henry, 2019-05-07, A Brief History of Simulation Neuroscience, Frontiers in Neuroinformatics, 13, 32, 10.3389/fninf.2019.00032, 31133838, 6513977, 1662-5196,

Modern neuroscience

(File:Nervous system diagram-en.svg|thumb|upright=1.3|Human nervous system)The scientific study of the nervous system increased significantly during the second half of the twentieth century, principally due to advances in molecular biology, electrophysiology, and computational neuroscience. This has allowed neuroscientists to study the nervous system in all its aspects: how it is structured, how it works, how it develops, how it malfunctions, and how it can be changed.For example, it has become possible to understand, in much detail, the complex processes occurring within a single neuron. Neurons are cells specialized for communication. They are able to communicate with neurons and other cell types through specialized junctions called synapses, at which electrical or electrochemical signals can be transmitted from one cell to another. Many neurons extrude a long thin filament of axoplasm called an axon, which may extend to distant parts of the body and are capable of rapidly carrying electrical signals, influencing the activity of other neurons, muscles, or glands at their termination points. A nervous system emerges from the assemblage of neurons that are connected to each other.The vertebrate nervous system can be split into two parts: the central nervous system (defined as the brain and spinal cord), and the peripheral nervous system. In many species — including all vertebrates — the nervous system is the most complex organ system in the body, with most of the complexity residing in the brain. The human brain alone contains around one hundred billion neurons and one hundred trillion synapses; it consists of thousands of distinguishable substructures, connected to each other in synaptic networks whose intricacies have only begun to be unraveled. At least one out of three of the approximately 20,000 genes belonging to the human genome is expressed mainly in the brain.U.S. National Institute of Neurological Disorders and Stroke. Brain basics: genes at work in the brain. Date last modified: 2018-12-27. weblink Retrieved Feb. 4, 2019.Due to the high degree of plasticity of the human brain, the structure of its synapses and their resulting functions change throughout life.The United States Department of Health and Human Services. Mental Health: A Report of the Surgeon General. "Chapter 2: The Fundamentals of Mental Health and Mental Illness" pp 38 weblink Retrieved May 21, 2012Making sense of the nervous system's dynamic complexity is a formidable research challenge. Ultimately, neuroscientists would like to understand every aspect of the nervous system, including how it works, how it develops, how it malfunctions, and how it can be altered or repaired. Analysis of the nervous system is therefore performed at multiple levels, ranging from the molecular and cellular levels to the systems and cognitive levels. The specific topics that form the main foci of research change over time, driven by an ever-expanding base of knowledge and the availability of increasingly sophisticated technical methods. Improvements in technology have been the primary drivers of progress. Developments in electron microscopy, computer science, electronics, functional neuroimaging, and genetics and genomics have all been major drivers of progress.

Molecular and cellular neuroscience

missing image!
- neuron colored.jpg -
Photograph of a stained neuron in a chicken embryo
Basic questions addressed in molecular neuroscience include the mechanisms by which neurons express and respond to molecular signals and how axons form complex connectivity patterns. At this level, tools from molecular biology and genetics are used to understand how neurons develop and how genetic changes affect biological functions. The morphology, molecular identity, and physiological characteristics of neurons and how they relate to different types of behavior are also of considerable interest.Questions addressed in cellular neuroscience include the mechanisms of how neurons process signals physiologically and electrochemically. These questions include how signals are processed by neurites and somas and how neurotransmitters and electrical signals are used to process information in a neuron. Neurites are thin extensions from a neuronal cell body, consisting of dendrites (specialized to receive synaptic inputs from other neurons) and axons (specialized to conduct nerve impulses called action potentials). Somas are the cell bodies of the neurons and contain the nucleus.Another major area of cellular neuroscience is the investigation of the development of the nervous system. Questions include the patterning and regionalization of the nervous system, neural stem cells, differentiation of neurons and glia (neurogenesis and gliogenesis), neuronal migration, axonal and dendritic development, trophic interactions, and synapse formation.Computational neurogenetic modeling is concerned with the development of dynamic neuronal models for modeling brain functions with respect to genes and dynamic interactions between genes.

Neural circuits and systems

(File:Leg Neural Network.jpg|thumb|Proposed organization of motor-semantic neural circuits for action language comprehension. Adapted from Shebani et al. (2013))Questions in systems neuroscience include how neural circuits are formed and used anatomically and physiologically to produce functions such as reflexes, multisensory integration, motor coordination, circadian rhythms, emotional responses, learning, and memory. In other words, they address how these neural circuits function in large scale brain networks, and the mechanisms through which behaviors are generated. For example, systems level analysis addresses questions concerning specific sensory and motor modalities: how does vision work? How do songbirds learn new songs and bats localize with ultrasound? How does the somatosensory system process tactile information? The related fields of neuroethology and neuropsychology address the question of how neural substrates underlie specific animal and human behaviors. Neuroendocrinology and psychoneuroimmunology examine interactions between the nervous system and the endocrine and immune systems, respectively. Despite many advancements, the way that networks of neurons perform complex cognitive processes and behaviors is still poorly understood.

Cognitive and behavioral neuroscience

Cognitive neuroscience addresses the questions of how psychological functions are produced by neural circuitry. The emergence of powerful new measurement techniques such as neuroimaging (e.g., fMRI, PET, SPECT), EEG, MEG, electrophysiology, optogenetics and human genetic analysis combined with sophisticated experimental techniques from cognitive psychology allows neuroscientists and psychologists to address abstract questions such as how cognition and emotion are mapped to specific neural substrates. Although many studies still hold a reductionist stance looking for the neurobiological basis of cognitive phenomena, recent research shows that there is an interesting interplay between neuroscientific findings and conceptual research, soliciting and integrating both perspectives. For example, the neuroscience research on empathy solicited an interesting interdisciplinary debate involving philosophy, psychology and psychopathology.Aragona M, Kotzalidis GD, Puzella A. (2013) The many faces of empathy, between phenomenology and neuroscience. Archives of Psychiatry and Psychotherapy, 4:5-12weblink Moreover, the neuroscientific identification of multiple memory systems related to different brain areas has challenged the idea of memory as a literal reproduction of the past, supporting a view of memory as a generative, constructive and dynamic process.JOURNAL, Ofengenden, Tzofit, 2014, Memory formation and belief,weblink Dialogues in Philosophy, Mental and Neuro Sciences, 7, 2, 34–44, Neuroscience is also allied with the social and behavioral sciences as well as nascent interdisciplinary fields such as neuroeconomics, decision theory, social neuroscience, and neuromarketing to address complex questions about interactions of the brain with its environment. A study into consumer responses for example uses EEG to investigate neural correlates associated with narrative transportation into stories about energy efficiency.JOURNAL, 10.1108/EJM-12-2016-0881, Using EEG to examine the role of attention, working memory, emotion, and imagination in narrative transportation, European Journal of Marketing, 52, 92–117, 2018, Gordon, Ross, Ciorciari, Joseph, Van Laer, Tom, 2892967,

Computational neuroscience

Questions in computational neuroscience can span a wide range of levels of traditional analysis, such as development, structure, and cognitive functions of the brain. Research in this field utilizes mathematical models, theoretical analysis, and computer simulation to describe and verify biologically plausible neurons and nervous systems. For example, biological neuron models are mathematical descriptions of spiking neurons which can be used to describe both the behavior of single neurons as well as the dynamics of neural networks. Computational neuroscience is often referred to as theoretical neuroscience.

Translational research and medicine

{{Further|Translational research |Translational neuroscience}}
missing image!
- Parasagittal MRI of human head in patient with benign familial macrocephaly prior to brain injury (ANIMATED).gif -
Parasagittal MRI of the head of a patient with benign familial macrocephaly
Neurology, psychiatry, neurosurgery, psychosurgery, anesthesiology and pain medicine, neuropathology, neuroradiology, ophthalmology, otolaryngology, clinical neurophysiology, addiction medicine, and sleep medicine are some medical specialties that specifically address the diseases of the nervous system. These terms also refer to clinical disciplines involving diagnosis and treatment of these diseases.Neurology works with diseases of the central and peripheral nervous systems, such as amyotrophic lateral sclerosis (ALS) and stroke, and their medical treatment. Psychiatry focuses on affective, behavioral, cognitive, and perceptual disorders. Anesthesiology focuses on perception of pain, and pharmacologic alteration of consciousness. Neuropathology focuses upon the classification and underlying pathogenic mechanisms of central and peripheral nervous system and muscle diseases, with an emphasis on morphologic, microscopic, and chemically observable alterations. Neurosurgery and psychosurgery work primarily with surgical treatment of diseases of the central and peripheral nervous systems.Recently, the boundaries between various specialties have blurred, as they are all influenced by basic research in neuroscience. For example, brain imaging enables objective biological insight into mental illnesses, which can lead to faster diagnosis, more accurate prognosis, and improved monitoring of patient progress over time.WEB, Lepage M, 2010, Research at the Brain Imaging Centre, Douglas Mental Health University Institute,weblink yes,weblink" title="web.archive.org/web/20120305042011weblink">weblink March 5, 2012, Integrative neuroscience describes the effort to combine models and information from multiple levels of research to develop a coherent model of the nervous system. For example, brain imaging coupled with physiological numerical models and theories of fundamental mechanisms may shed light on psychiatric disorders.JOURNAL, Gordon E, Integrative neuroscience., Neuropsychopharmacology, 2003, 28 Suppl 1, S2-8, 12827137, 10.1038/sj.npp.1300136,

Major branches

Modern neuroscience education and research activities can be very roughly categorized into the following major branches, based on the subject and scale of the system in examination as well as distinct experimental or curricular approaches. Individual neuroscientists, however, often work on questions that span several distinct subfields.{{clear right}}{| class="wikitable"|+ List of the major branches of neuroscience!Branch || Description
| Affective neuroscience
EDITOR=PUGLISI-ALLEGRA SISBN=978-0-7923-0682-5PAGES=41–58TITLE=PSYCHOBIOLOGY OF STRESS, 1990,
| Behavioral neuroscience| Behavioral neuroscience (also known as biological psychology, physiological psychology, biopsychology, or psychobiology) is the application of the principles of biology to the study of genetic, physiological, and developmental mechanisms of behavior in humans and non-human animals.
| Cellular neuroscience| Cellular neuroscience is the study of neurons at a cellular level including morphology and physiological properties.
| Clinical neuroscience
Scientific method>scientific study of the biological mechanisms that underlie the disorders and diseases of the nervous system.
| Cognitive neuroscience| Cognitive neuroscience is the study of the biological mechanisms underlying cognition.
| Computational neuroscience| Computational neuroscience is the theoretical study of the nervous system.
| Cultural neuroscience| Cultural neuroscience is the study of how cultural values, practices and beliefs shape and are shaped by the mind, brain and genes across multiple timescales.Chiao, J.Y. & Ambady, N. (2007). Cultural neuroscience: Parsing universality and diversity across levels of analysis. In Kitayama, S. and Cohen, D. (Eds.) Handbook of Cultural Psychology, Guilford Press, New York, pp. 237-254.
| Developmental neuroscience| Developmental neuroscience studies the processes that generate, shape, and reshape the nervous system and seeks to describe the cellular basis of neural development to address underlying mechanisms.
| Evolutionary neuroscience| Evolutionary neuroscience studies the evolution of nervous systems.
| Molecular neuroscience| Molecular neuroscience studies the nervous system with molecular biology, molecular genetics, protein chemistry, and related methodologies.
| Neural engineering| Neural engineering uses engineering techniques to interact with, understand, repair, replace, or enhance neural systems.
| Neuroanatomy| Neuroanatomy the study of the anatomy of nervous systems.
|Neurochemistry|Neurochemistry is the study of how neurochemicals interact and influence the function of neurons.
| Neuroethology| Neuroethology is the study of the neural basis of non-human animals behavior.
| Neurogastronomy
FIRST=SHEPHERD, GORDON M.OCLC=882238865, 2013-07-16,
|Neurogenetics|Neurogenetics is the study of the genetical basis of the development and function of the nervous system.
| Neuroimaging| Neuroimaging includes the use of various techniques to either directly or indirectly image the structure and function of the brain.
|Neuroimmunology|Neuroimmunology is concerned with the interactions between the nervous and the immune system.
| Neuroinformatics| Neuroinformatics is a discipline within bioinformatics that conducts the organization of neuroscience data and application of computational models and analytical tools.
| Neurolinguistics| Neurolinguistics is the study of the neural mechanisms in the human brain that control the comprehension, production, and acquisition of language.
| Neurophysics| Neurophysics deals with the development of physical experimental tools to gain information about the brain.
| Neurophysiology| Neurophysiology is the study of the functioning of the nervous system, generally using physiological techniques that include measurement and stimulation with electrodes or optically with ion- or voltage-sensitive dyes or light-sensitive channels.
| Neuropsychology| Neuropsychology is a discipline that resides under the umbrellas of both psychology and neuroscience, and is involved in activities in the arenas of both basic science and applied science. In psychology, it is most closely associated with biopsychology, clinical psychology, cognitive psychology, and developmental psychology. In neuroscience, it is most closely associated with the cognitive, behavioral, social, and affective neuroscience areas. In the applied and medical domain, it is related to neurology and psychiatry.
|Paleoneurobiology|Paleoneurobiology is a field which combines techniques used in paleontology and archeology to study brain evolution, especially that of the human brain.
| Social neuroscience| Social neuroscience is an interdisciplinary field devoted to understanding how biological systems implement social processes and behavior, and to using biological concepts and methods to inform and refine theories of social processes and behavior.
| Systems neuroscience| Systems neuroscience is the study of the function of neural circuits and systems.

Neuroscience organizations

The largest professional neuroscience organization is the Society for Neuroscience (SFN), which is based in the United States but includes many members from other countries. Since its founding in 1969 the SFN has grown steadily: as of 2010 it recorded 40,290 members from 83 different countries.WEB, Financial and organizational highlights, Society for Neuroscience,weblink yes,weblink" title="web.archive.org/web/20120915005024weblink">weblink September 15, 2012, Annual meetings, held each year in a different American city, draw attendance from researchers, postdoctoral fellows, graduate students, and undergraduates, as well as educational institutions, funding agencies, publishers, and hundreds of businesses that supply products used in research.Other major organizations devoted to neuroscience include the International Brain Research Organization (IBRO), which holds its meetings in a country from a different part of the world each year, and the Federation of European Neuroscience Societies (FENS), which holds a meeting in a different European city every two years. FENS comprises a set of 32 national-level organizations, including the British Neuroscience Association, the German Neuroscience Society (Neurowissenschaftliche Gesellschaft), and the French Société des Neurosciences. The first National Honor Society in Neuroscience, Nu Rho Psi, was founded in 2006.In 2013, the BRAIN Initiative was announced in the US. An International Brain Initiative was created in 2017,WEB,weblink International Brain Initiative {{!, The Kavli Foundation|website=www.kavlifoundation.org|access-date=2019-05-29}} currently integrated by more than seven national-level brain research initiatives (US, Europe, Allen Institute, Japan, China, Australia, Canada, Korea, Israel)JOURNAL, Rommelfanger, Karen S., Jeong, Sung-Jin, Ema, Arisa, Fukushi, Tamami, Kasai, Kiyoto, Ramos, Khara M., Salles, Arleen, Singh, Ilina, Amadio, Jordan, 2018, Neuroethics Questions to Guide Ethical Research in the International Brain Initiatives, Neuron, en, 100, 1, 19–36, 10.1016/j.neuron.2018.09.021, 30308169, spanning four continents.

Public education and outreach

In addition to conducting traditional research in laboratory settings, neuroscientists have also been involved in the promotion of awareness and knowledge about the nervous system among the general public and government officials. Such promotions have been done by both individual neuroscientists and large organizations. For example, individual neuroscientists have promoted neuroscience education among young students by organizing the International Brain Bee, which is an academic competition for high school or secondary school students worldwide.WEB, About the International Brain Bee, The International Brain Bee,weblink In the United States, large organizations such as the Society for Neuroscience have promoted neuroscience education by developing a primer called Brain Facts,WEB, Brain Facts: A Primer on the Brain and Nervous System, Society for Neuroscience,weblink collaborating with public school teachers to develop Neuroscience Core Concepts for K-12 teachers and students,WEB, Neuroscience Core Concepts: The Essential Principles of Neuroscience, Society for Neuroscience,weblink yes,weblink" title="web.archive.org/web/20120415042331weblink">weblink April 15, 2012, and cosponsoring a campaign with the Dana Foundation called Brain Awareness Week to increase public awareness about the progress and benefits of brain research.WEB, Brain Awareness Week Campaign, The Dana Foundation,weblink In Canada, the CIHR Canadian National Brain Bee is held annually at McMaster University.WEB,weblink Official CIHR Canadian National Brain Bee Website, 24 September 2014, yes,weblink" title="web.archive.org/web/20140530074023weblink">weblink May 30, 2014, Neuroscience educators formed Faculty for Undergraduate Neuroscience (FUN) in 1992 to share best practices and provide travel awards for undergraduates presenting at Society for Neuroscience meetingsweblink neuroscientists have also collaborated with other education experts to study and refine educational techniques to optimize learning among students, an emerging field called educational neuroscience.JOURNAL, Goswami U, 2004, Neuroscience, education and special education, Br J Spec Educ, 31, 4, 175–183, 10.1111/j.0952-3383.2004.00352.x, Federal agencies in the United States, such as the National Institute of Health (NIH)WEB,weblink The SEPA Program, National Institute of Health, NIH, September 23, 2011, yes,weblink" title="web.archive.org/web/20110920174421weblink">weblink September 20, 2011, and National Science Foundation (NSF),WEB,weblink About Education and Human Resources, National Science Foundation, NSF, September 23, 2011, have also funded research that pertains to best practices in teaching and learning of neuroscience concepts.">

Nobel prizes related to Neuroscience{| class"wikitable plainrowheaders sortable"

! scope=col | Year! scope=col | Prize field! scope=col class=unsortable| Image! scope=col | Laureate! scope=col | Lifetime! scope=col style="width: 100pt;" | Country! scope=col class=unsortable | Rationale! scope=col class=unsortable | Ref
| 1904
Nobel Prize in Physiology or Medicine>Physiology75px)Ivan Petrovich Pavlov| 1849–1936Russian Empire}}| "in recognition of his work on the physiology of digestion, through which knowledge on vital aspects of the subject has been transformed and enlarged"PUBLISHER=NOBEL FOUNDATION, 28 July 2007,
1906Physiology75px)Camillo Golgi| 1843–1926Kingdom of Italy}} "in recognition of their work on the structure of the nervous system" THE NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE 1906>URL=HTTP://WWW.NOBELPRIZE.ORG/NOBEL_PRIZES/MEDICINE/LAUREATES/1906/INDEX.HTMLACCESS-DATE=28 JULY 2007,
75px)Santiago Ramón y Cajal| 1852–1934Restoration (Spain)}}
| 1914
Nobel Prize in Physiology or Medicine>Physiology75px)Robert Bárány| 1876–1936Austria-Hungary}}| "for his work on the physiology and pathology of the vestibular apparatus"PUBLISHER=NOBEL FOUNDATION, 28 July 2007,
1932Physiology75px)Charles Scott Sherrington| 1857–1952United Kingdom}} "for their discoveries regarding the functions of neurons" THE NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE 1932>URL=HTTP://WWW.NOBELPRIZE.ORG/NOBEL_PRIZES/MEDICINE/LAUREATES/1932/INDEX.HTMLACCESS-DATE=28 JULY 2007,
75px)Edgar Douglas Adrian| 1889–1977United Kingdom}}
1936Physiology75px)Henry Hallett Dale| 1875–1968United Kingdom}} "for their discoveries relating to chemical transmission of nerve impulses" THE NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE 1936>URL=HTTP://WWW.NOBELPRIZE.ORG/NOBEL_PRIZES/MEDICINE/LAUREATES/1936/INDEX.HTMLACCESS-DATE=28 JULY 2007,
75px)Otto Loewi| 1873–1961Austria}}{{flagcountry|Nazi Germany}}
1944Physiology75px)Joseph Erlanger| 1874–1965United States|1912}} "for their discoveries relating to the highly differentiated functions of single nerve fibres" THE NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE 1944>URL=HTTP://WWW.NOBELPRIZE.ORG/NOBEL_PRIZES/MEDICINE/LAUREATES/1944/INDEX.HTMLACCESS-DATE=28 JULY 2007,
75px)Herbert Spencer Gasser| 1888–1963United States|1912}}
1949Physiology75px)Walter Rudolf Hess| 1881–1973Switzerland}}| "for his discovery of the functional organization of the interbrain as a coordinator of the activities of the internal organs"PUBLISHER=NOBEL FOUNDATION, 28 July 2007,
75px)António Caetano Egas Moniz| 1874–1955Portugal}}| "for his discovery of the therapeutic value of leucotomy in certain psychoses"|
| 1957
Nobel Prize in Physiology or Medicine>Physiology75px)Daniel Bovet| 1907–1992Italy}}| "for his discoveries relating to synthetic compounds that inhibit the action of certain body substances, and especially their action on the vascular system and the skeletal muscles"PUBLISHER=NOBEL FOUNDATION, 28 July 2007,
| 1961
Nobel Prize in Physiology or Medicine>Physiology75px)Georg von Békésy| 1899–1972United States}}| "for his discoveries of the physical mechanism of stimulation within the cochlea"PUBLISHER=NOBEL FOUNDATION, 28 July 2007,
1963Physiology75px)John Carew Eccles| 1903–1997Australia}} "for their discoveries concerning the ionic mechanisms involved in excitation and inhibition in the peripheral and central portions of the nerve cell membrane" HTTP://WWW.NOBELPRIZE.ORG/NOBEL_PRIZES/MEDICINE/LAUREATES/1970/INDEX.HTML>TITLE=THE NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE 1970FIRST=WEBSITE=ARCHIVE-URL=DEAD-URL=,
75px)Alan Lloyd Hodgkin| 1914–1998United Kingdom}}
75px)Andrew Fielding Huxley| 1917–2012United Kingdom}}
1967Physiology75px)Ragnar Granit| 1900–1991Finland}}{{flag|Sweden}} "for their discoveries concerning the primary physiological and chemical visual processes in the eye" HTTPS://WWW.NOBELPRIZE.ORG/PRIZES/MEDICINE/1981/SUMMARY/>TITLE=THE NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE 1981FIRST=WEBSITE=ARCHIVE-URL=DEAD-URL=,
75px)Haldan Keffer Hartline| 1903–1983United States}}
75px)George Wald| 1906–1997United States}}
1970Physiology||Julius Axelrod|1912–2004United States}}"for their discoveries concerning the humoral transmittors in the nerve terminals and the mechanism for their storage, release and inactivation"
109x109px)|Ulf von Euler|1905–1983Sweden}}
||Bernard Katz|1911–2003
United Kingdom}}
1981Physiology98x98px)Roger Wolcott Sperry>Roger W. Sperry|1913–1994United States}}|"for his discoveries concerning the functional specialization of the cerebral hemispheres"|
||David H. Hubel|1926–2013
Canada}}"for their discoveries concerning information processing in the visual system"
108x108px)Torsten Wiesel>Torsten N. Wiesel|1924–Sweden}}
1986Physiology75px)Stanley Cohen (biochemist)>Stanley Cohen|1922–United States}} "for their discoveries of growth factors" THE NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE 1986>URL=HTTP://WWW.NOBELPRIZE.ORG/NOBEL_PRIZES/MEDICINE/LAUREATES/1986/INDEX.HTMLACCESS-DATE=28 JULY 2007ARCHIVE-DATE=3 FEBRUARY 2014, no,
75px)|Rita Levi-Montalcini|1909–2012Italy}}
| 1997
Nobel Prize in Chemistry>Chemistry75px)Jens C. Skou| 1918–2018Denmark}}| "for the first discovery of an ion-transporting enzyme, Na+, K+ -ATPase"PUBLISHER=NOBEL FOUNDATION, 1 July 2019,
2000Physiology75px)|Arvid Carlsson| 1923–2018Sweden}} "for their discoveries concerning signal transduction in the nervous system"THE NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE 2000>URL=HTTP://WWW.NOBELPRIZE.ORG/NOBEL_PRIZES/MEDICINE/LAUREATES/2000/INDEX.HTMLACCESS-DATE=28 JULY 2007,
75px)| Paul Greengard| 1925–2019United States}}
75px)Eric Kandel>Eric R. Kandel| 1929–United States}}
| 2003
Nobel Prize in Chemistry>Chemistry75px|Roderick MacKinnon) Roderick MacKinnon| 1956–United States}}| "for discoveries concerning channels in cell membranes [...] for structural and mechanistic studies of ion channels"PUBLISHER=NOBEL FOUNDATION, 4 April 2019,
2014Physiology75px)John O'Keefe| 1939–United States}}{{flag|United Kingdom}} "for their discoveries of cells that constitute a positioning system in the brain" THE NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE 2014>URL=HTTP://WWW.NOBELPRIZE.ORG/NOBEL_PRIZES/MEDICINE/LAUREATES/2014/INDEX.HTMLACCESS-DATE=7 OCTOBER 2013,
75px)May-Britt Moser| 1963–Norway}}
75px)Edvard I. Moser| 1962–Norway}}
2017Physiology75px)Jeffrey C. Hall| 1939–United States}} "for their discoveries of molecular mechanisms controlling the circadian rhythm" THE NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE 2017>URL=HTTP://WWW.NOBELPRIZE.ORG/NOBEL_PRIZES/MEDICINE/LAUREATES/2017/INDEX.HTMLACCESS-DATE=2 OCTOBER 2017,
75px)Michael Rosbash| 1944–United States}}
75px)Michael W. Young| 1949–United States}}

See also

{{col div|colwidth=30em}} {{colend}}

References

{{Reflist|30em}}

Further reading

  • BEAR > FIRST = M. F.
AUTHOR3=M. A. PARADISO
, Neuroscience: Exploring the Brain
publisher = Lippincott, 2006, 3rd, 978-0-7817-6003-4,
  • BOOK, Binder, Marc D., Hirokawa, Nobutaka, Windhorst, Uwe, Encyclopedia of Neuroscience, Springer, 2009, 978-3-540-23735-8,weblink
  • BOOK
LAST = KANDEL, ERauthor3=Jessell TM
, Principles of Neural Science, 5th
location = New York, 2012, 978-0-8385-7701-1, Principles of Neural Science,
  • Squire, L. et al. (2012). Fundamental Neuroscience, 4th edition. Academic Press; {{ISBN|0-12-660303-0}}
  • Byrne and Roberts (2004). From Molecules to Networks. Academic Press; {{ISBN|0-12-148660-5}}
  • Sanes, Reh, Harris (2005). Development of the Nervous System, 2nd edition. Academic Press; {{ISBN|0-12-618621-9}}
  • Siegel et al. (2005). Basic Neurochemistry, 7th edition. Academic Press; {{ISBN|0-12-088397-X}}
  • Rieke, F. et al. (1999). Spikes: Exploring the Neural Code. The MIT Press; Reprint edition {{ISBN|0-262-68108-0}}
  • section.47 Neuroscience 2nd ed. Dale Purves, George J. Augustine, David Fitzpatrick, Lawrence C. Katz, Anthony-Samuel LaMantia, James O. McNamara, S. Mark Williams. Published by Sinauer Associates, Inc., 2001.
  • section.18 Basic Neurochemistry: Molecular, Cellular, and Medical Aspects 6th ed. by George J. Siegel, Bernard W. Agranoff, R. Wayne Albers, Stephen K. Fisher, Michael D. Uhler, editors. Published by Lippincott, Williams & Wilkins, 1999.
  • BOOK, Andreasen, Nancy C., Nancy_C._Andreasen, Brave New Brain: Conquering Mental Illness in the Era of the Genome, Oxford University Press, March 4, 2004,weblink yes, 978-0-19-514509-0,
,
  • Damasio, A. R. (1994). Descartes' Error: Emotion, Reason, and the Human Brain. New York, Avon Books. {{ISBN|0-399-13894-3}} (Hardcover) {{ISBN|0-380-72647-5}} (Paperback)
  • Gardner, H. (1976). The Shattered Mind: The Person After Brain Damage. New York, Vintage Books, 1976 {{ISBN|0-394-71946-8}}
  • Goldstein, K. (2000). The Organism. New York, Zone Books. {{ISBN|0-942299-96-5}} (Hardcover) {{ISBN|0-942299-97-3}} (Paperback)
  • BOOK, Lauwereyns, Jan, Jan_Lauwereyns, The Anatomy of Bias: How Neural Circuits Weigh the Options, The MIT Press, February 2010, Cambridge, Massachusetts,weblink 978-0-262-12310-5,
  • Subhash Kak, The Architecture of Knowledge: Quantum Mechanics, Neuroscience, Computers and Consciousness, Motilal Banarsidass, 2004, {{ISBN|81-87586-12-5}}
  • Llinas R. (2001). (I of the vortex: from neurons to self) MIT Press. {{ISBN|0-262-12233-2}} (Hardcover) {{ISBN|0-262-62163-0}} (Paperback)
  • Luria, A. R. (1997). The Man with a Shattered World: The History of a Brain Wound. Cambridge, Massachusetts, Harvard University Press. {{ISBN|0-224-00792-0}} (Hardcover) {{ISBN|0-674-54625-3}} (Paperback)
  • Luria, A. R. (1998). The Mind of a Mnemonist: A Little Book About A Vast Memory. New York, Basic Books, Inc. {{ISBN|0-674-57622-5}}
  • Medina, J. (2008). Brain Rules: 12 Principles for Surviving and Thriving at Work, Home, and School. Seattle, Pear Press. {{ISBN|0-9797777-0-4}} (Hardcover with DVD)
  • Pinker, S. (1999). How the Mind Works. W. W. Norton & Company. {{ISBN|0-393-31848-6}}
  • Pinker, S. (2002). The Blank Slate: The Modern Denial of Human Nature. Viking Adult. {{ISBN|0-670-03151-8}}
  • BOOK
FIRST = D. L., Brain, Mind and Behaviour: A New Perspective on Human Nature publisher = Pontoon Publications, 2009, 2nd, 978-0-9561812-0-6,

External links

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