aesthetics  →
being  →
complexity  →
database  →
enterprise  →
ethics  →
fiction  →
history  →
internet  →
knowledge  →
language  →
licensing  →
linux  →
logic  →
method  →
news  →
perception  →
philosophy  →
policy  →
purpose  →
religion  →
science  →
sociology  →
software  →
truth  →
unix  →
wiki  →
essay  →
feed  →
help  →
system  →
wiki  →
critical  →
discussion  →
forked  →
imported  →
original  →
[ temporary import ]
please note:
- the content below is remote from Wikipedia
- it has been imported raw for GetWiki
{{About|synapses of the nervous system||3=Synapse (disambiguation)}}{{Synapse map}}{{Presynaptic_synapse}}In the nervous system, a synapseBOOK, Foster, M., Sherrington, C.S., Textbook of Physiology, volume 3, 1897, Macmillan, London, 929, 7th, is a structure that permits a neuron (or nerve cell) to pass an electrical or chemical signal to another neuron or to the target effector cell.Santiago Ramón y Cajal proposed that neurons are not continuous throughout the body, yet still communicate with each other,(like cabbages) an idea known as the neuron doctrine.BOOK, Elias, Lorin J., Saucier, Deborah M., Neuropsychology: Clinical and Experimental Foundations, 2006, Pearson Education, Pearson/Allyn & Bacon, Boston, 978-0-20534361-4, 61131869, 2005051341, The word "synapse" – from the Greek synapsis (), meaning "conjunction", in turn from ( ("together") and ("to fasten")) – was introduced in 1897 by the English neurophysiologist Charles Sherrington in Michael Foster's Textbook of Physiology. Sherrington struggled to find a good term that emphasized a union between two separate elements, and the actual term "synapse" was suggested by the English classical scholar Arthur Woollgar Verrall, a friend of Foster.WEB, synapse,weblink Online Etymology Dictionary, 2013-10-01, live,weblink" title="">weblink 2013-12-14, JOURNAL, Tansey, E.M., 1997, Not committing barbarisms: Sherrington and the synapse, 1897, Brain Research Bulletin, 44, 3, 211–212, Amsterdam, Elsevier, 9323432, 10.1016/S0361-9230(97)00312-2, The word synapse first appeared in 1897, in the seventh edition of Michael Foster's Textbook of Physiology., Some authors generalize the concept of the synapse to include the communication from a neuron to any other cell type,BOOK, Schacter, Daniel L., Daniel Schacter, Gilbert, Daniel T., Daniel Gilbert (psychologist), Wegner, Daniel M., Daniel Wegner, Psychology, 2nd, 2011, Worth Publishers, New York, 80, 978-1-4292-3719-2, 696604625, 2010940234, such as to a motor cell, although such non-neuronal contacts may be referred to as junctions (a historically older term).Synapses are essential to neuronal function: neurons are cells that are specialized to pass signals to individual target cells, and synapses are the means by which they do so. At a synapse, the plasma membrane of the signal-passing neuron (the presynaptic neuron) comes into close apposition with the membrane of the target (postsynaptic) cell. Both the presynaptic and postsynaptic sites contain extensive arrays of a molecular machinery that link the two membranes together and carry out the signaling process. In many synapses, the presynaptic part is located on an axon and the postsynaptic part is located on a dendrite or soma. Astrocytes also exchange information with the synaptic neurons, responding to synaptic activity and, in turn, regulating neurotransmission.JOURNAL, Perea, G., Navarrete, M., Araque, A., August 2009, Tripartite synapses: astrocytes process and control synaptic information, Trends (journals), Trends in Neurosciences, 32, 8, 421–431, Cambridge, MA, Cell Press, 19615761, 10.1016/j.tins.2009.05.001, Synapses (at least chemical synapses) are stabilized in position by synaptic adhesion molecules (SAMs) projecting from both the pre- and post-synaptic neuron and sticking together where they overlap; SAMs may also assist in the generation and functioning of synapses.JOURNAL, 3312681, 22278667, 10.1101/cshperspect.a005694, 4, Synaptic cell adhesion, 2012, Cold Spring Harb Perspect Biol, a005694, Missler, M, Südhof, TC, Biederer, T, {{Clear}}

Chemical or electrical?

File:Neuro Muscular Junction.png|thumb|An example of chemical synapse by the release of neurotransmitters like acetylcholine or glutamic acidglutamic acidThere are two fundamentally different types of synapses:
  • In a chemical synapse, electrical activity in the presynaptic neuron is converted (via the activation of voltage-gated calcium channels) into the release of a chemical called a neurotransmitter that binds to receptors located in the plasma membrane of the postsynaptic cell. The neurotransmitter may initiate an electrical response or a secondary messenger pathway that may either excite or inhibit the postsynaptic neuron. Chemical synapses can be classified according to the neurotransmitter released: glutamatergic (often excitatory), GABAergic (often inhibitory), cholinergic (e.g. vertebrate neuromuscular junction), and adrenergic (releasing norepinephrine). Because of the complexity of receptor signal transduction, chemical synapses can have complex effects on the postsynaptic cell.
  • In an electrical synapse, the presynaptic and postsynaptic cell membranes are connected by special channels called gap junctions or synaptic cleft that are capable of passing an electric current, causing voltage changes in the presynaptic cell to induce voltage changes in the postsynaptic cell. The main advantage of an electrical synapse is the rapid transfer of signals from one cell to the next.BOOK, Silverthorn, Dee Unglaub, Illustration coordinator William C. Ober; illustrations by Claire W. Garrison; clinical consultant Andrew C. Silverthorn; contributions by Bruce R. Johnson, Human Physiology: An Integrated Approach, 4th, 2007, Pearson Education, Pearson/Benjamin Cummings, San Francisco, 271, 978-0-8053-6851-2, 62742632, 2005056517,
Synaptic communication is distinct from an ephaptic coupling, in which communication between neurons occurs via indirect electric fields.An autapse is a chemical or electrical synapse that forms when the axon of one neuron synapses onto dendrites of the same neuron.

Types of interfaces

Synapses can be classified by the type of cellular structures serving as the pre- and post-synaptic components. The vast majority of synapses in the mammalian nervous system are classical axo-dendritic synapses (axon synapsing upon a dendrite), however, a variety of other arrangements exist. These include but are not limited to axo-axonic, dendro-dendritic, axo-secretory, somato-dendritic, dendro-somatic, and somato-somatic synapses.The axon can synapse onto a dendrite, onto a cell body, or onto another axon or axon terminal, as well as into the bloodstream or diffusely into the adjacent nervous tissue.(File:Blausen 0843 SynapseTypes.png|thumb|500px|center|Different types of synapses)

Role in memory

It is widely accepted that the synapse plays a role in the formation of memory. As neurotransmitters activate receptors across the synaptic cleft, the connection between the two neurons is strengthened when both neurons are active at the same time, as a result of the receptor's signaling mechanisms. The strength of two connected neural pathways is thought to result in the storage of information, resulting in memory. This process of synaptic strengthening is known as long-term potentiation.JOURNAL, Lynch, M. A., January 1, 2004, Long-Term Potentiation and Memory, Physiological Reviews, 84, 1, 87–136, 14715912, 10.1152/physrev.00014.2003,weblink By altering the release of neurotransmitters, the plasticity of synapses can be controlled in the presynaptic cell. The postsynaptic cell can be regulated by altering the function and number of its receptors. Changes in postsynaptic signaling are most commonly associated with a N-methyl-d-aspartic acid receptor (NMDAR)-dependent long-term potentiation (LTP) and long-term depression (LTD) due to the influx of calcium into the post-synaptic cell, which are the most analyzed forms of plasticity at excitatory synapses.JOURNAL, Krugers, Harm J., Zhou, Ming, Joëls, Marian, Kindt, Merel, October 11, 2011, Regulation of Excitatory Synapses and Fearful Memories by Stress Hormones, Frontiers in Behavioral Neuroscience, 5, 62, Switzerland, Frontiers (publisher), Frontiers Media SA, 10.3389/fnbeh.2011.00062, 3190121, 22013419,

Study models

For technical reasons, synaptic structure and function have been historically studied at unusually large model synapses, for example:

Synaptic polarization

The function of neurons depends upon cell polarity. The distinctive structure of nerve cells allows action potentials to travel directionally (from dendrites to cell body down the axon), and for these signals to then be received and carried on by post-synaptic neurons or received by effector cells. Nerve cells have long been used as models for cellular polarization, and of particular interest are the mechanisms underlying the polarized localization of synaptic molecules. PIP2 signaling regulated by IMPase plays an integral role in synaptic polarity.Phosphoinositides (PIP, PIP2, and PIP3) are molecules that have been shown to affect neuronal polarity.JOURNAL, Arimura, Nariko, Kaibuchi, Kozo, December 22, 2005, Key regulators in neuronal polarity, Neuron (journal), Neuron, 48, 6, 881–884, Cambridge, MA, Cell Press, 16364893, 10.1016/j.neuron.2005.11.007, A gene (ttx-7) was identified in Caenorhabditis elegans that encodes myo-inositol monophosphatase (IMPase), an enzyme that produces inositol by dephosphorylating inositol phosphate. Organisms with mutant ttx-7 genes demonstrated behavioral and localization defects, which were rescued by expression of IMPase. This led to the conclusion that IMPase is required for the correct localization of synaptic protein components.JOURNAL, Kimata, Tsubasa, Tanizawa, Yoshinori, Can, Yoko, Ikeda, Shingo, Kuhara, Atsushi, Mori, Ikue, June 1, 2012, Synaptic Polarity Depends on Phosphatidylinositol Signaling Regulated by myo-Inositol Monophosphatase in Caenorhabditis elegans, Genetics (journal), Genetics, 191, 2, 509–521, Bethesda, MD, Genetics Society of America, 22446320, 10.1534/genetics.111.137844, 3, 3374314, JOURNAL, Tanizawa, Yoshinori, Kuhara, Atsushi, Inada, Hitoshi, Kodama, Eiji, Mizuno, Takafumi, Mori, Ikue, December 1, 2006, Inositol monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans, Genes & Development, 20, 23, 3296–3310, Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press, 17158747, 1686606, 10.1101/gad.1497806, 3, The egl-8 gene encodes a homolog of phospholipase Cβ (PLCβ), an enzyme that cleaves PIP2. When ttx-7 mutants also had a mutant egl-8 gene, the defects caused by the faulty ttx-7 gene were largely reversed. These results suggest that PIP2 signaling establishes polarized localization of synaptic components in living neurons.

Presynaptic modulation

Modulation of neurotransmitter release by G-protein-coupled receptors (GPCRs) is a prominent presynaptic mechanism for regulation of synaptic transmission. The activation of GPCRs located at the presynaptic terminal, can decrease the probability of neurotransmitter release. This presynaptic depression involves activation of Gi/o-type G-proteins that mediate different inhibitory mechanisms, including inhibition of voltage-gated calcium channels, activation of potassium channels, and direct inhibition of the vesicle fusion process. Endocannabinoids, synthesized in and released from postsynaptic neuronal elements, and their cognate receptors, including the (GPCR) CB1 receptor, located at the presynaptic terminal, are involved in this modulation by an retrograde signaling process, in which these compounds are synthesized in and released from postsynaptic neuronal elements, and travel back to the presynaptic terminal to act on the CB1 receptor for short-term (STD) or long-term synaptic depression (LTD), that cause a short or long lasting decrease in neurotransmitter release.{{Citation|last=Lovinger|first=David M.|title=Presynaptic Modulation by Endocannabinoids|date=2008|url=|work=Pharmacology of Neurotransmitter Release|pages=435–477|editor-last=Südhof|editor-first=Thomas C.|series=Handbook of Experimental Pharmacology|publisher=Springer Berlin Heidelberg|language=en|doi=10.1007/978-3-540-74805-2_14|isbn=9783540748052|access-date=2019-08-01|editor2-last=Starke|editor2-first=Klaus}}

Additional images

Image:Neuron synapse.png|A typical central nervous system synapse
Image:Active zone3.JPG|The synapse and synaptic vesicle cycle
Image:Chemical synapse schema cropped.jpg|Major elements in chemical synaptic transmission

See also

{{col div|colwidth=30em}} {{colend}}


{{Reflist|30em}}{{Nervous tissue}}{{Authority control}}

- content above as imported from Wikipedia
- "synapse" does not exist on GetWiki (yet)
- time: 12:49am EDT - Wed, Oct 16 2019
[ this remote article is provided by Wikipedia ]
LATEST EDITS [ see all ]
Eastern Philosophy
History of Philosophy
M.R.M. Parrott