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viral infection>Viral, bacterial, allergies| risks =| diagnosis = Based on symptoms, microbial culture| differential =| prevention = Handwashing| treatment = Based on underlying cause| medication =| prognosis =| frequency = 3–6 million per year (US)| deaths =}}Conjunctivitis, also known as pink eye,WEB,weblink What is Viral Conjunctivitis a.k.a. Sore Eyes? | National Institutes of Health, is inflammation of the outermost layer of the white part of the eye and the inner surface of the eyelid.JOURNAL, Richards A, Guzman-Cottrill JA, Conjunctivitis, Pediatrics in Review, 31, 5, 196–208, May 2010, 20435711, 10.1542/pir.31-5-196, 245084568, It makes the eye appear pink or reddish. Pain, burning, scratchiness, or itchiness may occur. The affected eye may have increased tears or be "stuck shut" in the morning. Swelling of the white part of the eye may also occur. Itching is more common in cases due to allergies. Conjunctivitis can affect one or both eyes.The most common infectious causes in adults are viral, whereas in children bacterial causes predominate.JOURNAL, Durand, Marlene L., Barshak, Miriam B., Sobrin, Lucia, Eye Infections, New England Journal of Medicine, 21 December 2023, 389, 25, 2363–2375, 10.1056/NEJMra2216081, 38118024, 266433325, JOURNAL, Azari AA, Barney NP, Conjunctivitis: a systematic review of diagnosis and treatment, JAMA, 310, 16, 1721–9, October 2013, 24150468, 4049531, 10.1001/jama.2013.280318, The viral infection may occur along with other symptoms of a common cold. Both viral and bacterial cases are easily spread between people. Allergies to pollen or animal hair are also a common cause. Diagnosis is often based on signs and symptoms. Occasionally, a sample of the discharge is sent for culture.Prevention is partly by handwashing. Treatment depends on the underlying cause.WEB, Facts About Pink Eye,weblink National Eye Institute, 8 March 2016, November 2015, live,weblink 9 March 2016, dmy-all, In the majority of viral cases, there is no specific treatment. Most cases due to a bacterial infection also resolve without treatment; however, antibiotics can shorten the illness. People who wear contact lenses and those whose infection is caused by gonorrhea or chlamydia should be treated. Allergic cases can be treated with antihistamines or mast cell inhibitor drops.About 3 to 6 million people get acute conjunctivitis each year in the United States. Typically, people get better in one or two weeks. If visual loss, significant pain, sensitivity to light or signs of herpes occur, or if symptoms do not improve after a week, further diagnosis and treatment may be required. Conjunctivitis in a newborn, known as neonatal conjunctivitis, may also require specific treatment.{{TOC limit}}

Signs and symptoms

(File:Bloodshot eye.jpg|thumb|Bloodshot eyes)Red eye, swelling of the conjunctiva, and watering of the eyes are symptoms common to all forms of conjunctivitis. However, the pupils should be normally reactive, and the visual acuity normal.{{Citation |last1=Hashmi |first1=Muhammad F. |title=Conjunctivitis |date=2023 |url=http://www.ncbi.nlm.nih.gov/books/NBK541034/ |work=StatPearls |access-date=2023-05-23 |place=Treasure Island (FL) |publisher=StatPearls Publishing |pmid=31082078 |last2=Gurnani |first2=Bharat |last3=Benson |first3=Scarlet}}Conjunctivitis is identified by inflammation of the conjunctiva, manifested by irritation and redness. Examination using a slit lamp (biomicroscope) may improve diagnostic accuracy. Examination of the palpebral conjunctiva, that overlying the inner aspects of the eyelids, is usually more diagnostic than examination of the bulbal conjunctiva, that overlying the sclera.{{citation needed|date=September 2022}}

Viral

(File:Conjunctivitis disease.jpg|thumb|Viral conjunctivitis)Approximately 80% of cases of conjunctivitis in adults and less than 20% in children are due to viruses, with 65% to 90% of these cases being attributed to adenoviruses.JOURNAL, Conjunctivitis: a systematic review of diagnosis and treatment, JAMA, 2013, 310, 16, 1721–1730, 10.1001/jama.2013.280318, 24150468, 4049531, Azari, A. A., Barney, N. P., Viral conjunctivitis is often associated with an infection of the upper respiratory tract, a common cold, or a sore throat. Other associated signs may include pre-auricular lymph node swelling and contact with another person with a red eye. Eye pain may be present if the cornea is also involved. Its symptoms include excessive watering and itching. The discharge in viral conjunctivitis is usually (but not always) watery in nature. The infection usually begins in one eye but may spread easily to the other eye.{{citation needed|date=February 2023}}Viral conjunctivitis manifests as a fine, diffuse pinkness of the conjunctiva which may be mistaken for iritis, but corroborative signs on microscopy, particularly numerous lymphoid follicles on the tarsal conjunctiva, and sometimes a punctate keratitis are seen.{{citation needed|date=February 2023}}

Allergic

File:Allergicconjunctivitis.jpg|thumb|right|An eye with allergic conjunctivitisallergic conjunctivitisAllergic conjunctivitis is inflammation of the conjunctiva due to allergy.JOURNAL, Bielory L, Friedlaender MH, Allergic conjunctivitis, Immunology and Allergy Clinics of North America, 28, 1, 43–58, vi, February 2008, 18282545, 10.1016/j.iac.2007.12.005, 34371872, The specific allergens may differ among patients. Symptoms result from the release of histamine and other active substances by mast cells, and consist of redness (mainly due to vasodilation of the peripheral small blood vessels), swelling of the conjunctiva, itching, and increased production of tears.{{citation needed|date=September 2022}}

Bacterial

(File:Swollen eye with conjunctivitis.jpg|thumb|right|An eye with bacterial conjunctivitis)Bacteria are responsible for approximately 70% of conjunctivitis in children and less than 20% of cases in adults. Common bacteria responsible for bacterial conjunctivitis are Staphylococcus including Staph aureus, Streptococcus such as strep pneumoniae,WEB, Pink Eye (Conjunctivitis), MedicineNet,weblink live,weblink" title="web.archive.org/web/20130622062209weblink">weblink 22 June 2013, dmy-all, Haemophilus species and Moraxella catarrhalis. Less commonly, Chlamydia spp. and Niesseria species (Neisseria gonorrhoeae and Neisseria meningitidis) may be the cause.WEB, Acute Bacterial Conjunctivitis – Eye Disorders,weblink Merck Manuals Professional Edition, 31 December 2016, live,weblink" title="web.archive.org/web/20161228184316weblink">weblink 28 December 2016, dmy-all, Bacterial conjunctivitis usually causes a rapid onset of conjunctival redness, swelling of the eyelid, and a sticky discharge. Typically, symptoms develop first in one eye, but may spread to the other eye within 2–5 days. Conjunctivitis due to common pus-producing bacteria causes marked grittiness or irritation and a stringy, opaque, greyish or yellowish discharge that may cause the lids to stick together, especially after sleep. Severe crusting of the infected eye and the surrounding skin may also occur. The gritty or scratchy feeling is sometimes localized enough that patients may insist that they have a foreign body in the eye.{{citation needed|date=September 2022}}(File:Membranous conjunctivitis.jpg|thumb|right|Typical membranous conjunctivitis)Bacteria such as Chlamydia trachomatis or Moraxella spp. can cause a nonexudative but persistent conjunctivitis without much redness. Bacterial conjunctivitis may cause the production of membranes or pseudomembranes that cover the conjunctiva. Pseudomembranes consist of a combination of inflammatory cells and exudates and adhere loosely to the conjunctiva, while true membranes are more tightly adherent and cannot be easily peeled away. Cases of bacterial conjunctivitis that involve the production of membranes or pseudomembranes are associated with Neisseria gonorrhoeae, β-hemolytic streptococci, and Corynebacterium diphtheriae. C. diphtheriae causes membrane formation in conjunctiva of unimmunized children.BOOK, Epidemiology and Prevention of Vaccine-Preventable Diseases, Hamborsky J, Kroger A, Wolfe C, U.S. Dept. of Health & Human Services, Centers for Disease Control and Prevention, 2015, 978-0-9904491-1-9, 112,

Chemical

Chemical eye injury may result when an acidic or alkaline substance gets in the eye.JOURNAL, Zentani A, Burslem J, Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. BET 4: use of litmus paper in chemical eye injury, Emergency Medicine Journal, 26, 12, 887, December 2009, 19934140, 10.1136/emj.2009.086124, 38124735, Alkali burns are typically worse than acidic burns. Mild burns produce conjunctivitis, while more severe burns may cause the cornea to turn white. Litmus paper may be used to test for chemical causes. When a chemical cause has been confirmed, the eye or eyes should be flushed until the pH is in the range 6–8.JOURNAL, Hodge C, Lawless M, Ocular emergencies, Australian Family Physician, 37, 7, 506–9, July 2008, 18592066, Anaesthetic eye drops can be used to decrease the pain.Irritant or toxic conjunctivitis is primarily marked by redness. If due to a chemical splash, it is often present in only the lower conjunctival sac. With some chemicals, above all with caustic alkalis such as sodium hydroxide, necrosis of the conjunctiva marked by a deceptively white eye due to vascular closure may occur, followed by sloughing off of the dead epithelium. A slit lamp examination is likely to show evidence of anterior uveitis.{{citation needed|date=September 2022}}

Biomarkers

Omics technologies have been used to identify biomarkers that inform on the emergence and progression of conjunctivitis. For example, in chronic inflammatory cicatrizing conjunctivitis, active oxylipins, lysophospholipids, fatty acids, and endocannabinoids alterations, from which potential biomarkers linked to inflammatory processes were identified.JOURNAL, 32313985, 2020, Di Zazzo, A., Yang, W., Coassin, M., Micera, A., Antonini, M., Piccinni, F., De Piano, M., Kohler, I., Harms, A. C., Hankemeier, T., Boinini, S., Mashaghi, A., Signaling lipids as diagnostic biomarkers for ocular surface cicatrizing conjunctivitis, Journal of Molecular Medicine, 98, 5, 751–760, 10.1007/s00109-020-01907-w, 7220886,

Other

(File:Chlamydial-conjunctivitis.jpg|thumb|right|An eye with chlamydial conjunctivitis)Inclusion conjunctivitis of the newborn is a conjunctivitis that may be caused by the bacterium Chlamydia trachomatis, and may lead to acute, purulent conjunctivitis.BOOK, Fisher, Bruce, Harvey, Richard P., Champe, Pamela C., Lippincott's Illustrated Reviews: Microbiology (Lippincott's Illustrated Reviews Series), Lippincott Williams & Wilkins, Hagerstown MD, 2007, 978-0-7817-8215-9, However, it is usually self-healing.

Causes

Infective conjunctivitis is most commonly caused by a virus. Bacterial infections, allergies, other irritants, and dryness are also common causes. Both bacterial and viral infections are contagious, passing from person to person or spread through contaminated objects or water. Contact with contaminated fingers is a common cause of conjunctivitis. Bacteria may also reach the conjunctiva from the edges of the eyelids and the surrounding skin, from the nasopharynx, from infected eye drops or contact lenses, from the genitals or the bloodstream. Infection by human adenovirus accounts for 65% to 90% of cases of viral conjunctivitis.JOURNAL, Singh MP, Ram J, Kumar A, Rungta T, Gupta A, Khurana J, Ratho RK, Molecular epidemiology of circulating human adenovirus types in acute conjunctivitis cases in Chandigarh, North India, Indian Journal of Medical Microbiology, 36, 1, 113–115, 2018, 29735838, 10.4103/ijmm.ijmm_17_258, free,

Viral

Adenoviruses are the most common cause of viral conjunctivitis (adenoviral keratoconjunctivitis). Herpetic keratoconjunctivitis, caused by herpes simplex viruses, can be serious and requires treatment with aciclovir. Acute hemorrhagic conjunctivitis is a highly contagious disease caused by one of two enteroviruses, enterovirus 70 and coxsackievirus A24. These were first identified in an outbreak in Ghana in 1969, and have spread worldwide since then, causing several epidemics.JOURNAL, Lévêque N, Huguet P, Norder H, Chomel JJ, [Enteroviruses responsible for acute hemorrhagic conjunctivitis], fr, Médecine et Maladies Infectieuses, 40, 4, 212–8, April 2010, 19836177, 10.1016/j.medmal.2009.09.006,

Bacterial

The most common causes of acute bacterial conjunctivitis are Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae.BOOK, Yanoff, Myron, Duker, Jay S., Ophthalmology, 2008, Mosby, Edinburgh, 978-0-323-05751-6, 227–236, 3rd, WEB,weblink Protect Yourself From Pink Eye, CDC, 2017-10-02, Centers for Disease Control and Prevention, en-us, 2018-12-07, Though very rare, hyperacute cases are usually caused by Neisseria gonorrhoeae or Neisseria meningitidis. Chronic cases of bacterial conjunctivitis are those lasting longer than 3 weeks, and are typically caused by S. aureus, Moraxella lacunata, or Gram-negative enteric flora.{{citation needed|date=September 2022}}

Allergic

Conjunctivitis may also be caused by allergens such as pollen, perfumes, cosmetics, smoke,WEB,weblink Allergic Conjunctivitis, familydoctor.org, 18 September 2015, live,weblink" title="web.archive.org/web/20150906031026weblink">weblink 6 September 2015, dmy-all, {{Unreliable medical source|date=September 2015}} dust mites, Balsam of Peru,BOOK,weblink The Daily Telegraph: Complete Guide to Allergies, Pamela, Brooks, 25 October 2012, Little, Brown Book, 15 April 2014, 978-1-4721-0394-9, {{Dead link|date=September 2023 |bot=InternetArchiveBot |fix-attempted=yes }} or eye drops.WEB,weblink What Is Allergic Conjunctivitis? What Causes Allergic Conjunctivitis?, medicalnewstoday.com, 6 April 2010, live,weblink" title="web.archive.org/web/20100316174827weblink">weblink 16 March 2010, dmy-all, The most frequent cause of conjunctivitis is allergic conjunctivitis and it affects 15% to 40% of the population. Allergic conjunctivitis accounts for 15% of eye related primary care consultations; most including seasonal exposures in the spring and summer or perpetual conditions.JOURNAL, Perkin MR, Bader T, Rudnicka AR, Strachan DP, Owen CG, Inter-Relationship between Rhinitis and Conjunctivitis in Allergic Rhinoconjunctivitis and Associated Risk Factors in Rural UK Children, PLOS ONE, 10, 11, e0143651, 2015-11-24, 26600465, 4658044, 10.1371/journal.pone.0143651, 2015PLoSO..1043651P, free,

Other

• Computer vision syndrome
• Dry eye syndrome
• Reactive arthritis: Conjunctivitis is part of the triad of reactive arthritis, which is thought to be caused by autoimmune cross-reactivity following certain bacterial infections. Reactive arthritis is highly associated with HLA-B27. Conjunctivitis is associated with the autoimmune disease relapsing polychondritis.JOURNAL, Puéchal X, Terrier B, Mouthon L, Costedoat-Chalumeau N, Guillevin L, Le Jeunne C, Relapsing polychondritis, Joint, Bone, Spine, 81, 2, 118–24, March 2014, 24556284, 10.1016/j.jbspin.2014.01.001, 205754989,weblink JOURNAL, Cantarini L, Vitale A, Brizi MG, Caso F, Frediani B, Punzi L, Galeazzi M, Rigante D, Diagnosis and classification of relapsing polychondritis, Journal of Autoimmunity, 48-49, 53–9, 2014, 24461536, 10.1016/j.jaut.2014.01.026,

Diagnosis

(File:Procedure of conjunctival swabs.jpg|thumb|The procedure of conjunctival swabs)Cultures are not often taken or needed as most cases resolve either with time or typical antibiotics. If bacterial conjunctivitis is suspected, but no response to topical antibiotics is seen, swabs for bacterial culture should be taken and tested. Viral culture may be appropriate in epidemic case clusters.{{Citation |last1=Sheikh |first1=Aziz |title=BACTERIAL CONJUNCTIVITIS 372.05 (Infective Conjunctivitis, Mucopurulent Conjunctivitis, Purulent Conjunctivitis) |date=2008 |url=http://dx.doi.org/10.1016/b978-1-4160-2447-7.50182-1 |work=Roy and Fraunfelder's Current Ocular Therapy |pages=332–334 |access-date=2023-05-23 |publisher=Elsevier |last2=Hurwitz |first2=Brian|doi=10.1016/b978-1-4160-2447-7.50182-1 |isbn=978-1-4160-2447-7 }}A patch test is used to identify the causative allergen in allergic conjunctivitis.BOOK,weblink Eye and skin disease, Mark J., Mannis, Marian S., Macsai, Arthur C., Huntley, Lippincott-Raven, 1996, 23 April 2014, live,weblink" title="web.archive.org/web/20140705035958weblink">weblink 5 July 2014, dmy-all, 978-0-7817-0269-0, Although conjunctival scrapes for cytology can be useful in detecting chlamydial and fungal infections, allergies, and dysplasia, they are rarely done because of the cost and the general dearth of laboratory staff experienced in handling ocular specimens. Conjunctival incisional biopsy is occasionally done when granulomatous diseases (e.g., sarcoidosis)JOURNAL, Korkmaz Ekren, Pervin, Mogulkoc, Nesrin, Toreyin, Zehra Nur, Egrilmez, Sait, Veral, Ali, Akalın, Taner, Bacakoglu, Feza, 2016-10-07, Conjunctival Biopsy as a First Choice to Confirm a Diagnosis of Sarcoidosis,weblink Sarcoidosis, Vasculitis, and Diffuse Lung Diseases, 33, 3, 196–200, 2532-179X, 27758983, or dysplasia are suspected.{{Citation |last1=Roberts |first1=Fiona |title=The Conjunctival Biopsy |date=2021 |url=https://doi.org/10.1007/978-3-030-76525-5_11 |work=Lee's Ophthalmic Histopathology |pages=343–388 |editor-last=Roberts |editor-first=Fiona |access-date=2023-12-10 |place=Cham |publisher=Springer International Publishing |language=en |doi=10.1007/978-3-030-76525-5_11 |isbn=978-3-030-76525-5 |last2=Thum |first2=Chee Koon |editor2-last=Thum |editor2-first=Chee Koon}}

Classification

Conjunctivitis may be classified either by cause or by extent of the inflamed area.{{citation needed|date=February 2023}}

Causes

• Allergy
• Bacteria
• Viruses
• Chemicals
• Autoimmune

Neonatal conjunctivitis is often grouped separately from bacterial conjunctivitis because it is caused by different bacteria than the more common cases of bacterial conjunctivitis.{{citation needed|date=February 2023}}

By extent of involvement

Blepharoconjunctivitis is the dual combination of conjunctivitis with blepharitis (inflammation of the eyelids).{{citation needed|date=February 2023}}Keratoconjunctivitis is the combination of conjunctivitis and keratitis (corneal inflammation).{{citation needed|date=February 2023}}Blepharokeratoconjunctivitis is the combination of conjunctivitis with blepharitis and keratitis. It is clinically defined by changes of the lid margin, meibomian gland dysfunction, redness of the eye, conjunctival chemosis and inflammation of the cornea.JOURNAL, O'Gallagher M, Banteka M, Bunce C, Larkin F, Tuft S, Dahlmann-Noor A, Systemic treatment for blepharokeratoconjunctivitis in children, The Cochrane Database of Systematic Reviews, 5, CD011750, May 2016, 2016, 27236587, 10.1002/14651858.CD011750.pub2, 9257284,

Differential diagnosis

Some more serious conditions can present with a red eye, such as infectious keratitis, angle-closure glaucoma, or iritis. These conditions require the urgent attention of an ophthalmologist. Signs of such conditions include decreased vision, significantly increased sensitivity to light, inability to keep the eye open, a pupil that does not respond to light, or a severe headache with nausea.BOOK, Longo DL, Harrison's Principles of Internal Medicine, 2012, McGra-Hill, Disorders of the Eye(Horton JC), Fluctuating blurring is common, due to tearing and mucoid discharge. Mild photophobia is common. However, if any of these symptoms is prominent, considering other diseases such as glaucoma, uveitis, keratitis, and even meningitis or carotico-cavernous fistula is important.{{citation needed|date=September 2022}}A more comprehensive differential diagnosis for the red or painful eye includes:

• Corneal abrasion
• Subconjunctival hemorrhage
• Pinguecula
• Blepharitis
• Dacryocystitis
• Keratoconjunctivitis sicca (dry eye)
• Keratitis
• Herpes simplex
• Herpes zoster
• Episcleritis - an inflammatory condition that produces a similar appearance to conjunctivitis, but without discharge or tearing
• Uveitis
• Acute angle-closure glaucoma
• Endophthalmitis
• Orbital cellulitis

Prevention

The most effective prevention is good hygiene, especially avoiding rubbing the eyes with infected hands. Vaccination against some of the causative pathogens such as Haemophilus influenzae, pneumococcus, and Neisseria meningitidis is also effective.NEWS,weblink Protect Yourself From Pink Eye, 2 October 2017, Centers for Disease Control and Prevention, 18 October 2017, en-us, Povidone-iodine eye solution has been found to prevent neonatal conjunctivitis. It is becoming more commonly used globally because of its low cost.JOURNAL, Isenberg SJ, The ocular application of povidone-iodine, Community Eye Health, 16, 46, 30–1, 2003, 17491857, 1705857,

Management

Conjunctivitis resolves in 65% of cases without treatment, within 2–5 days. The prescription of antibiotics is not necessary in most cases.JOURNAL, Rose P, Management strategies for acute infective conjunctivitis in primary care: a systematic review, Expert Opinion on Pharmacotherapy, 8, 12, 1903–21, August 2007, 17696792, 10.1517/14656566.8.12.1903, 45899988,

Viral

Viral conjunctivitis usually resolves on its own and does not require any specific treatment. Antihistamines (e.g., diphenhydramine) or mast cell stabilizers (e.g., cromolyn) may be used to help with the symptoms. Povidone-iodine has been suggested as a treatment, but as of 2008, evidence to support it was poor.BOOK, Jimmy D., Bartlett, Siret D., Jaanus, Clinical Ocular Pharmacology,weblink 2008, Elsevier Health Sciences, 978-0-7506-7576-5, 454–, live,weblink 3 December 2016, dmy-all,

Allergic

For allergic conjunctivitis, cool water poured over the face with the head inclined downward constricts capillaries, and artificial tears sometimes relieve discomfort in mild cases. In more severe cases, nonsteroidal anti-inflammatory medications and antihistamines may be prescribed. Persistent allergic conjunctivitis may also require topical steroid drops.JOURNAL, Allergic eye disease, 10.1136/bmj.j4706, British Medical Journal, 2017, 359, j4706, Darshak S, Patel, Meena, Arunakirinathan, Alastair, Stuart, Romesh, Angunawela, 29097360, 5316455,

Bacterial

Bacterial conjunctivitis usually resolves without treatment. Topical antibiotics may be needed only if no improvement is observed after 3 days.JOURNAL, Visscher KL, Hutnik CM, Thomas M, Evidence-based treatment of acute infective conjunctivitis: Breaking the cycle of antibiotic prescribing, Canadian Family Physician, 55, 11, 1071–5, November 2009, 19910590, 2776793, No serious effects were noted either with or without treatment.JOURNAL, Chen, Yu-Yen, Liu, Su-Hsun, Nurmatov, Ulugbek, van Schayck, Onno Cp, Kuo, Irene C., 2023-03-13, Antibiotics versus placebo for acute bacterial conjunctivitis, The Cochrane Database of Systematic Reviews, 3, 3, CD001211, 10.1002/14651858.CD001211.pub4, 1469-493X, 10014114, 36912752, Because antibiotics do speed healing in bacterial conjunctivitis, their use may be considered. Antibiotics are also recommended for those who wear contact lenses, are immunocompromised, have disease which is thought to be due to chlamydia or gonorrhea, have a fair bit of pain, or have copious discharge. Gonorrheal or chlamydial infections require both oral and topical antibiotics.The choice of antibiotic varies based on the strain or suspected strain of bacteria causing the infection. Fluoroquinolones, sodium sulfacetamide, or trimethoprim/polymyxin may be used, typically for 7–10 days. Cases of meningococcal conjunctivitis can also be treated with systemic penicillin, as long as the strain is sensitive to penicillin.{{citation needed|date=September 2022}}When investigated as a treatment, povidone-iodine ophthalmic solution has also been observed to have some effectiveness against bacterial and chlamydial conjunctivitis, with a possible role suggested in locations where topical antibiotics are unavailable or costly.JOURNAL, Isenberg SJ, Apt L, Valenton M, Del Signore M, Cubillan L, Labrador MA, Chan P, Berman NG, A controlled trial of povidone-iodine to treat infectious conjunctivitis in children, American Journal of Ophthalmology, 134, 5, 681–8, November 2002, 12429243, 10.1016/S0002-9394(02)01701-4,

Chemical

Conjunctivitis due to chemicals is treated via irrigation with Ringer's lactate or saline solution. Chemical injuries, particularly alkali burns, are medical emergencies, as they can lead to severe scarring and intraocular damage. People with chemically induced conjunctivitis should not touch their eyes to avoid spreading the chemical.WEB, Conjunctivitis, American Optometric Association,weblink March 15, 2024,

Epidemiology

Conjunctivitis is the most common eye disease.BOOK, Smeltzer, Suzanne C., Brunner & Suddarth's textbook of medical-surgical nursing., 2010, Wolters Kluwer Health/Lippincott Williams & Wilkins, Philadelphia, 978-0-7817-8589-1, 1787, 12th,weblink live,weblink 15 August 2016, dmy-all, Rates of disease is related to the underlying cause which varies by the age as well as the time of year. Acute conjunctivitis is most frequently found in infants, school-age children and the elderly.JOURNAL, Høvding G, Acute bacterial conjunctivitis, Acta Ophthalmologica, 86, 1, 5–17, February 2008, 17970823, 10.1111/j.1600-0420.2007.01006.x, 20629824, free, The most common cause of infectious conjunctivitis is viral conjunctivitis.JOURNAL, Mourad, Mervat Salah, Rihan, Rafat Ali, 80882721, April 2018, Prevalence of Different Eye Diseases excluding Refractive Errors Presented at the Outpatient Clinic in Beheira Eye Hospital, The Egyptian Journal of Hospital Medicine, en, 71, 2, 2484–2489, 10.12816/0045645, It is estimated that acute conjunctivitis affects 6 million people annually in the United States.Some seasonal trends have been observed for the occurrence of different forms of conjunctivitis. In the northern hemisphere, the occurrence of bacterial conjunctivitis peaks from December to April, viral conjunctivitis peaks in the summer months and allergic conjunctivitis is more prevalent throughout the spring and summer.

History

An adenovirus was first isolated by Rowe et al. in 1953. Two years later, Jawetz et al. published on epidemic keratoconjunctivitis.JOURNAL, Jhanji V, Chan TC, Li EY, Agarwal K, Vajpayee RB, Adenoviral keratoconjunctivitis, Survey of Ophthalmology, 60, 5, 435–43, September–October 2015, 26077630, 10.1016/j.survophthal.2015.04.001, {{rp|437}} "Madras eye" is a colloquial term that has been used in India for the disease.

Outbreak in Pakistan

In September 2023, a significant outbreak of conjunctivitis occurred in Pakistan. The outbreak began in Karachi and quickly spread to Lahore, Rawalpindi, and Islamabad. By the end of the month, over 86,133 cases had been reported in Punjab alone. The rapid spread of the disease led to the temporary closure of schools in the region. This event marked one of the largest outbreaks of Pink Eye in the country's recent history.WEB,weblink From pink eye to blindness, 28 September 2023, WEB,weblink 86,133 pink eye cases in Punjab in September and counting, 28 September 2023, NEWS, Ahmed, Salman, Punjab Announces Holiday for Schools Amid Pink Eye Outbreak,weblink Propakistani, 27 September 2023, WEB,weblink 85 new cases of Pink Eye infection reported in Pakistan's Lahore - ET HealthWorld,

Society and culture

Conjunctivitis imposes economic and social burdens. The cost of treating bacterial conjunctivitis in the United States was estimated to be $377 million to $857 million per year. Approximately 1% of all primary care office visits in the United States are related to conjunctivitis. Approximately 70% of all people with acute conjunctivitis present to primary care and urgent care.

See also

• Conjunctival suffusion
• Ophthalmia

References

{{Reflist}}

External links

{{commons category|Conjunctivitis}}

• WEB,weblink U.S. National Library of Medicine, MedlinePlus, Pink Eye,
• WEB,weblink MSBB Group, Leiden University, Metabolomics for Ocular Surface Disease,

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