GetWiki

{{Short description|Measure of drug activity}}{{ou|Potency (disambiguation)}}{{mi|{{more footnotes needed|date=March 2016}}{{more science citations needed|date=March 2016}}}}(File:Potency Figure16.png|thumb|Concentration-response curves illustrating the concept of potency. For a response of 0.25a.u., Drug B is more potent, as it generates this response at a lower concentration. For a response of 0.75a.u., Drug A is more potent. a.u. refers to “arbitrary units”.)In pharmacology, potency or biological potencyMILES AA, PERRY EL. Biological potency and its relation to therapeutic efficacy. Bull World Health Organ. 1953;9(1):1-14. PMID: 13082386; PMCID: PMC2542104. is a measure of a drug’s biological activity expressed in terms of the dose required to produce a pharmacological effect of given intensity.JOURNAL, Neubig RR, Spedding M, Kenakin T, Christopoulos A,pharmrev.aspetjournals.org/content/55/4/597, International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology, Pharmacological Reviews, 55, 4, 597–606, December 2003, 14657418, 10.1124/pr.55.4.4, 1729572, A highly potent drug (e.g., fentanyl, clonazepam, risperidone, benperidol, bumetanide) evokes a given response at low concentrations, while a drug of lower potency (e.g. morphine, alprazolam, ziprasidone, haloperidol, furosemide) evokes the same response only at higher concentrations. Higher potency does not necessarily mean greater effectiveness or more side effects.

Types of potency

The International Union of Basic and Clinical Pharmacology (IUPHAR) has stated that “potency is an imprecise term that should always be further defined”, and lists of types of potency as follows:{| {{table}}! Type of potency ! Symbol! Definition

ED-50>Effective dose|ED_{50}|It is the minimum dose or concentration of a drug that produces a biological response in 50% of a population being studied.

LD50>Median lethal dose|LD_{50}|For either drugs or toxins, it is a toxic unit that measures the minimum dose that causes death (lethal dose) in 50% of cases.

TD50>Median toxic dose|TD_{50}|It is the minimum dose at which toxicity occurs in 50% of cases.

EC50>Half maximal effective concentration|EC_{50}	drug, antibody or toxicant which induces a biological response halfway between the baseline and maximum after a specified exposure time. In other words, it can be defined as the concentration required to obtain a 50% effect.HTTP://WWW.GRAPHPAD.COM/CURVEFIT/INTRODUCTION89.HTM	ARCHIVE-URL=HTTPS://WEB.ARCHIVE.ORG/WEB/20120730150339/HTTP://WWW.GRAPHPAD.COM/CURVEFIT/INTRODUCTION89.HTM	PUBLISHER=GRAPHPAD SOFTWARE,

IC50>Half maximal inhibitory concentration|IC_{50}|It is a measure of the potency of a substance in inhibiting a specific biological or biochemical function.

See also

• Reaction inhibitor § Potency

References

{{reflist}}

Further reading

• NEWS, Robert, Harris, Formulating High Potency Drugs, 2012-10-09,www.contractpharma.com/issues/2012-10/view_features/formulating-high-potency-drugs/, Contract Pharma, 2013-11-13,
• BOOK, Walker MG, Page CP, Hoffman BF, Curtis M, Integrated Pharmacology, 3rd, Mosby, St. Louis, 2006, 978-0-323-04080-8,

www.addictioncenter.com/news/2019/08/15-most-dangerous-drugs/https://nida.nih.gov/research-topics/commonly-used-drugs-charts#top{{Pharmacology}}