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genetic marker
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- the content below is remote from Wikipedia
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{{Short description|Gene or DNA sequence with a known location on a chromosome}}A genetic marker is a gene or DNA sequence with a known location on a chromosome that can be used to identify individuals or species. It can be described as a variation (which may arise due to mutation or alteration in the genomic loci) that can be observed. A genetic marker may be a short DNA sequence, such as a sequence surrounding a single base-pair change (single nucleotide polymorphism, SNP), or a long one, like minisatellites.- the content below is remote from Wikipedia
- it has been imported raw for GetWiki
Background
For many years, gene mapping was limited to identifying organisms by traditional phenotypes markers. This included genes that encoded easily observable characteristics such as blood types or seed shapes. The insufficient number of these types of characteristics in several organisms limited the mapping efforts that could be done. This prompted the development of gene markers which could identify genetic characteristics that are not readily observable in organisms (such as protein variation).BOOK, Benjamin A. Pierce, Genetics: A Conceptual Approach, 2013-12-27, Macmillan Learning, 978-1-4641-0946-1,Types
(File:SFP discovery principle.jpg|thumb|SFP discovery principle for gene probing)Some commonly used types of genetic markers are:- RFLP (or Restriction fragment length polymorphism)
- SSLP (or Simple sequence length polymorphism)
- AFLP (or Amplified fragment length polymorphism)
- RAPD (or Random amplification of polymorphic DNA)
- VNTR (or Variable number tandem repeat)
- SSCP (or Single-strand conformation polymorphism)
- {{visible anchor|SSR}} Microsatellite polymorphism, (or Simple sequence repeat)BOOK, Wani, Shabir Hussain, Disease Resistance in Crop Plants : Molecular, Genetic and Genomic Perspectives, Springer Publishing, Springer, Cham, Switzerland, 2019, 978-3-030-20727-4, 1110184027, 83â112/xii+307, 5 Rice, Marker-Assisted Breeding, and Disease Resistance, Mehta, Sahil, Singh, Baljinder, Dhakate, Priyanka, Rahman, Mehzabin, Islam, Muhammad Aminul, {{ISBN|978-3-030-20728-1}}.
- SNP (or Single nucleotide polymorphism)
- STR (or Short tandem repeat)
- SFP (or Single feature polymorphism)
- DArT (or Diversity Arrays Technology)
- RAD markers (or Restriction site associated DNA markers)
- {{visible anchor|STS}} (using Sequence-tagged sites)
Uses
Genetic markers can be used to study the relationship between an inherited disease and its genetic cause (for example, a particular mutation of a gene that results in a defective protein). It is known that pieces of DNA that lie near each other on a chromosome tend to be inherited together. This property enables the use of a marker, which can then be used to determine the precise inheritance pattern of the gene that has not yet been exactly localized.{{Anchor|uniparental marker}}Genetic markers are employed in genealogical DNA testing for genetic genealogy to determine genetic distance between individuals or populations. Uniparental markers (on mitochondrial or Y chromosomal DNA) are studied for assessing maternal or paternal lineages. Autosomal markers are used for all ancestry.Genetic markers have to be easily identifiable, associated with a specific locus, and highly polymorphic, because homozygotes do not provide any information. Detection of the marker can be direct by RNA sequencing, or indirect using allozymes.Some of the methods used to study the genome or phylogenetics are RFLP, AFLP, RAPD, SSR. They can be used to create genetic maps of whatever organism is being studied.There was a debate over what the transmissible agent of CTVT (canine transmissible venereal tumor) was. Many researchers hypothesized that virus like particles were responsible for transforming the cell, while others thought that the cell itself was able to infect other canines as an allograft. With the aid of genetic markers, researchers were able to provide conclusive evidence that the cancerous tumor cell evolved into a transmissible parasite. Furthermore, molecular genetic markers were used to resolve the issue of natural transmission, the breed of origin (phylogenetics), and the age of the canine tumor.Murgia C, Pritchard JK, Kim SY, Fassati A, Weiss RA. Clonal origin and evolution of a transmissible cancer. Cell. 2006 Aug 11;126(3):477-87.Genetic markers have also been used to measure the genomic response to selection in livestock. Natural and artificial selection leads to a change in the genetic makeup of the cell. The presence of different alleles due to a distorted segregation at the genetic markers is indicative of the difference between selected and non-selected livestock.JOURNAL, Gomez-Raya L, Olsen HG, Lingaas F, Klungland H, VÃ¥ge DI, Olsaker I, Talle SB, Aasland M, Lien S, The use of genetic markers to measure genomic response to selection in livestock, Genetics, 162, 3, 1381â8, November 2002, 10.1093/genetics/162.3.1381, 12454081, 1462338,See also
- Marker gene
- Molecular marker
- DNA marking
- Eukaryotic chromosome fine structure
- Repeated sequence (DNA)
References
{{Reflist}}Further reading
- BOOK
, de Vicente C, Fulton T
, 2003
, Molecular Marker Learning Modules â Vol. 1.
, IPGRI, Rome, Italy and Institute for Genetic Diversity, Ithaca, New York, USA.
,www.bioversityinternational.org/publications/molecular_markers_module_volume_1_en.html
, {{Dead link|date=December 2019 |bot=InternetArchiveBot |fix-attempted=yes }}
, 2003
, Molecular Marker Learning Modules â Vol. 1.
, IPGRI, Rome, Italy and Institute for Genetic Diversity, Ithaca, New York, USA.
,www.bioversityinternational.org/publications/molecular_markers_module_volume_1_en.html
, {{Dead link|date=December 2019 |bot=InternetArchiveBot |fix-attempted=yes }}
- BOOK
, de Vicente C, Fulton T
, 2004
, Molecular Marker Learning Modules â Vol. 2.
, IPGRI, Rome, Italy and Institute for Genetic Diversity, Ithaca, New York, USA.
,www.bioversityinternational.org/training/training_materials/genetic_diversity_analysis_with_molecular_marker_data_learning_module_volume_2.html
, , 2004
, Molecular Marker Learning Modules â Vol. 2.
, IPGRI, Rome, Italy and Institute for Genetic Diversity, Ithaca, New York, USA.
,www.bioversityinternational.org/training/training_materials/genetic_diversity_analysis_with_molecular_marker_data_learning_module_volume_2.html
- BOOK
, de Vicente C, Glaszmann JC
, 2006
, Molecular Markers for Allele Mining
, AMS (Bioversity’s Regional Office for the Americas), CIRAD, GCP, IPGRI, M.S. Swaminathan Research Foundation
,www.bioversityinternational.org/Publications/pubfile.asp?ID_PUB=1134
, 85
, 2007-12-12
,www.bioversityinternational.org/Publications/pubfile.asp?ID_PUB=1134" title="web.archive.org/web/20071204074800www.bioversityinternational.org/Publications/pubfile.asp?ID_PUB=1134">web.archive.org/web/20071204074800www.bioversityinternational.org/Publications/pubfile.asp?ID_PUB=1134
, 2007-12-04
, dead
,
, 2006
, Molecular Markers for Allele Mining
, AMS (Bioversity’s Regional Office for the Americas), CIRAD, GCP, IPGRI, M.S. Swaminathan Research Foundation
,www.bioversityinternational.org/Publications/pubfile.asp?ID_PUB=1134
, 85
, 2007-12-12
,www.bioversityinternational.org/Publications/pubfile.asp?ID_PUB=1134" title="web.archive.org/web/20071204074800www.bioversityinternational.org/Publications/pubfile.asp?ID_PUB=1134">web.archive.org/web/20071204074800www.bioversityinternational.org/Publications/pubfile.asp?ID_PUB=1134
, 2007-12-04
, dead
,
- BOOK
, Spooner D, van Treuren R, de Vicente MC
, 2005
, Molecular markers for genebank management
, CGN, IPGRI, USDA
,www.bioversityinternational.org/Publications/pubfile.asp?ID_PUB=1082
, 126
, 2007-12-12
,www.bioversityinternational.org/publications/pubfile.asp?id_pub=1082" title="web.archive.org/web/20080503213410www.bioversityinternational.org/publications/pubfile.asp?id_pub=1082">web.archive.org/web/20080503213410www.bioversityinternational.org/publications/pubfile.asp?id_pub=1082
, 2008-05-03
, dead
,
, 2005
, Molecular markers for genebank management
, CGN, IPGRI, USDA
,www.bioversityinternational.org/Publications/pubfile.asp?ID_PUB=1082
, 126
, 2007-12-12
,www.bioversityinternational.org/publications/pubfile.asp?id_pub=1082" title="web.archive.org/web/20080503213410www.bioversityinternational.org/publications/pubfile.asp?id_pub=1082">web.archive.org/web/20080503213410www.bioversityinternational.org/publications/pubfile.asp?id_pub=1082
, 2008-05-03
, dead
,
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