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{{chembox|Watchedfields = changed|verifiedrevid = 437791930|ImageFile = Diphenylphosphine.svg|ImageName = Ball-and-stick model|ImageFile1 = Diphenylphosphine-3D-balls.png|ImageName1 = Ball-and-stick model|ImageFile2 = Diphenylphosphine-3D-vdW.png|PIN = Diphenylphosphane|Section1={{Chembox Identifiers

correct|chemspider}}|ChemSpiderID = 63209|InChI = 1/C12H11P/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h1-10,13H|SMILES = c2c(Pc1ccccc1)cccc2|InChIKey = GPAYUJZHTULNBE-UHFFFAOYAN

correct|chemspider}}|StdInChI = 1S/C12H11P/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h1-10,13H

correct|chemspider}}|StdInChIKey = GPAYUJZHTULNBE-UHFFFAOYSA-N

correct|CAS}}|CASNo = 829-85-6|PubChem = 70017|EC_number = 212-591-4|UNII = F9B5T7O7ZY}}|Section2={{Chembox Properties|Formula = C12H11P|MolarMass = 186.19 g/mol|Appearance = colorless liquid|Density = 1.07 g/cm3, liquid|Solubility = Insoluble|BoilingPtC = 280}}|Section3={{Chembox Hazards|GHSPictograms = {{GHS02}}{{GHS07}}|GHSSignalWord = Danger

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422|501}}|ExternalSDS = External MSDS}}}}Diphenylphosphine, also known as diphenylphosphane, is an organophosphorus compound with the formula (C6H5)2PH. This foul-smelling, colorless liquid is easily oxidized in air. It is a precursor to organophosphorus ligands for use as catalysts. Synthesis Diphenylphosphine can be prepared from triphenylphosphine by reduction to lithium diphenylphosphide, which can be protonated to give the title compound:BOOK, Inorganic Syntheses, Diphenylphosphine, V. D. Bianco, S. Doronzo, 1976, 16, 161–188, 10.1002/9780470132470.ch43, 9780470132470, PPh3 + 2 Li → LiPPh2 + LiPh LiPPh2 + H2O → Ph2PH + LiOH Uses and reactions In the laboratory, diphenylphosphine is a common intermediate. It can be deprotonated to give diphenylphosphide derivatives:ENCYCLOPEDIA, Piotrowski, D. W., Diphenylphosphine, Encyclopedia of Reagents for Organic Synthesis, John Wiley & Sons, New York, 2001, 10.1002/047084289X.rd427, 0471936235, Ph2PH + nBuLi → Ph2PLi + nBuH The preparation of phosphine ligands, Wittig-Horner reagents, and phosphonium salts are commonly accomplished by alkylating diphenylphosphine. The hydrogen atom connected to phosphorus undergoes Michael-like addition to activated alkenes, providing products with which to produce phosphine ligands such as 1,2-bis(diphenylphosphino)ethane (Ph2PC2H4PPh2) and BINAP.{{OrgSynth |last=Cai |first=Dongwei |author2=J. F. Payack |author3=D. R. Bender |author4=D. L. Hughes |author5=T. R. Verhoeven |author6=P. J. Reider |year=1999 |title=(R)-(+)- and (S)-(−)-2,2′-bis(diphenylphosphino)-1,1′-binapthyl (BINAP)|volume=76 |pages=6|prep=v76p0006}} via its bistriflate derivatives. Both the (R)- and (S)-enantiomers, as well as the racemate, are commercially available. One of the wide applications include chemoselective hydrogenation, where BINAP is conjugated to rhodium.Diphenylphosphine and especially diphenylphosphide derivatives are nucleophiles, so they add to carbon – heteroatom double bonds. For example, in the presence of concentrated hydrochloric acid at 100 °C, diphenylphosphine adds to the carbon atom in benzaldehyde to give (phenyl-(phenylmethyl)phosphoryl)benzene. Ph2PH + PhCHO → Ph2P(O)CH2Ph Compared to tertiary phosphines, diphenylphosphine is weakly basic. The pKa of the protonated derivative is 0.03:C. A. Streuli, "Determination of Basicity of Substituted Phosphines by Nonaqueous Titrimetry", Analytical Chemistry 1960, volume 32, pages 985-987.{{doi|10.1021/ac60164a027}} Ph2PH2+ {{eqm}} Ph2PH + H+ Handling properties Diphenylphosphine readily oxidizes.{{Ullmann | author = Svara, J. | author2 = Weferling, N. | author3 = Hofmann, T. | title = Phosphorus Compounds, Organic | doi = 10.1002/14356007.a19_545.pub2}} Ph2PH + O2 → Ph2P(O)OH An intermediate in this oxidation is diphenylphosphine oxide. The use of the diphenylphosphine–borane complex, Ph2PH•BH3 avoids the problem of phosphine oxidation by protecting the phosphine from oxidation and is available through chemical vendors. References {{Reflist}}