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acetylcholine receptor
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{{Short description|Integral membrane protein}}File:NAChR.png|thumb|300px| Nicotinic acetylcholine receptorNicotinic acetylcholine receptorImage:Acetylcholine.svg|thumb|AcetylcholineAcetylcholineAn acetylcholine receptor (abbreviated AChR) or a cholinergic receptor is an integral membrane protein that responds to the binding of acetylcholine, a neurotransmitter.- the content below is remote from Wikipedia
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Classification
Like other transmembrane receptors, acetylcholine receptors are classified according to their “pharmacology,” or according to their relative affinities and sensitivities to different molecules. Although all acetylcholine receptors, by definition, respond to acetylcholine, they respond to other molecules as well.- Nicotinic acetylcholine receptors (nAChR, also known as “ionotropic” acetylcholine receptors) are particularly responsive to nicotine. The nicotine ACh receptor is also a Na+, K+ and Ca2+ ion channel.
- Muscarinic acetylcholine receptors (mAChR, also known as “metabotropic” acetylcholine receptors) are particularly responsive to muscarine.
Receptor types
Molecular biology has shown that the nicotinic and muscarinic receptors belong to distinct protein superfamilies. Nicotinic receptors are of two types: Nm and Nn. NmWEB,image.slidesharecdn.com/anspharmacologyandcholinergics-drdhritiupdated2011-111228115516-phpapp02/95/autonomic-nervous-system-pharmacology-and-cholinergics-updated-2011-drdhriti-47-728.jpg?cb=1382965154, Reference at image.slidesharecdn.com, is located in the neuromuscular junction which causes the contraction of skeletal muscles by way of end-plate potential (EPPs). Nn causes depolarization in autonomic ganglia resulting in post ganglionic impulse. Nicotinic receptors cause the release of catecholamine from the adrenal medulla, and also site specific excitation or inhibition in brain. Both Nm and Nn are Na+ and Ca2+ channel linked but Nn is also linked with an extra K+ channel.nAChR
The nAChRs are ligand-gated ion channels, and, like other members of the “cys-loop” ligand-gated ion channel superfamily, are composed of five protein subunits symmetrically arranged like staves around a barrel. The subunit composition is highly variable across different tissues. Each subunit contains four regions which span the membrane and consist of approximately 20 amino acids. Region II which sits closest to the pore lumen, forms the pore lining.Binding of acetylcholine to the N termini of each of the two alpha subunits results in the 15° rotation of all M2 helices.JOURNAL, Doyle DA, Structural changes during ion channel gating, Trends Neurosci., 27, 6, 298â302, 2004, 15165732, 10.1016/j.tins.2004.04.004, 36451231, The cytoplasm side of the nAChR receptor has rings of high negative charge that determine the specific cation specificity of the receptor and remove the hydration shell often formed by ions in aqueous solution. In the intermediate region of the receptor, within the pore lumen, valine and leucine residues (Val 255 and Leu 251) define a hydrophobic region through which the dehydrated ion must pass.JOURNAL, Miyazawa A, Fujiyoshi Y, Unwin N, Structure and gating mechanism of the acetylcholine receptor pore, Nature, 423, 6943, 949â55, 2003, 12827192, 10.1038/nature01748, 2003Natur.423..949M, 205209809, The nAChR is found at the edges of junctional folds at the neuromuscular junction on the postsynaptic side; it is activated by acetylcholine release across the synapse. The diffusion of Na+ and K+ across the receptor causes depolarization, the end-plate potential, that opens voltage-gated sodium channels, which allows for firing of the action potential and potentially muscular contraction.mAChR
In contrast, the mAChRs are not ion channels, but belong instead to the superfamily of G-protein-coupled receptors that activate other ionic channels via a second messenger cascade.The muscarine cholinergic receptor activates a G-protein when bound to extracellular ACh. The alpha subunit of the G-protein activates guanylate cyclase (inhibiting the effects of intracellular cAMP) while the beta-gamma subunit activates the K-channels and therefore hyperpolarize the cell. This causes a decrease in cardiac activity.Origin and evolution
ACh receptors are related to GABA, glycine, and 5-HT3 receptors and their similar protein sequence and gene structure strongly suggest that they evolved from a common ancestral receptor.JOURNAL, Ortells, M. O., Lunt, G. G., March 1995, Evolutionary history of the ligand-gated ion-channel superfamily of receptors,pubmed.ncbi.nlm.nih.gov/7754520, Trends in Neurosciences, 18, 3, 121â127, 10.1016/0166-2236(95)93887-4, 0166-2236, 7754520, 18062185, In fact, relatively minor mutations, such as a change in 3 amino acids in many of these receptors can convert a cation-selective channel to an anion-selective channel gated by acetylcholine, showing that even fundamental properties can relatively easily change in evolution.JOURNAL, Galzi, J. L., Devillers-Thiéry, A., Hussy, N., Bertrand, S., Changeux, J. P., Bertrand, D., 1992-10-08, Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic,pubmed.ncbi.nlm.nih.gov/1383829, Nature, 359, 6395, 500â505, 10.1038/359500a0, 0028-0836, 1383829, 1992Natur.359..500G, 4266961,Pharmacology
Acetylcholine receptor modulators can be classified by which receptor subtypes they act on:{| class=“wikitable“|+ ACh and its receptors! Drug !! Nm !! Nn !! M1 !! M2 !! M3ACh, Carbachol, Methacholine, AChEI (Physostigmine, Galantamine, Neostigmine, Pyridostigmine) > | | + |
Nicotine, Varenicline > | | |
Succinylcholine > | | |
Atracurium, Vecuronium, Tubocurarine, Pancuronium > | | |
Epibatidine, DMPP > | | |
Trimethaphan, Mecamylamine, Bupropion, Dextromethorphan, Hexamethonium > | | |
Muscarine, Oxotremorine, Bethanechol, Pilocarpine > | | + |
Atropine, Tolterodine, Oxybutynin > | | - |
Vedaclidine, Talsaclidine, Xanomeline, Ipratropium > | | |
Pirenzepine, Telenzepine > | | |
Methoctramine > | | |
Darifenacin, 4-DAMP, Solifenacin > | | - |
Role in health and disease
Nicotinic acetylcholine receptors can be blocked by curare, hexamethonium and toxins present in the venoms of snakes and shellfishes, like α-bungarotoxin. Drugs such as the neuromuscular blocking agents bind reversibly to the nicotinic receptors in the neuromuscular junction and are used routinely in anaesthesia. Nicotinic receptors are the primary mediator of the effects of nicotine. In myasthenia gravis, the receptor at the neuromuscular junction is targeted by antibodies, leading to muscle weakness.Muscarinic acetylcholine receptors can be blocked by the drugs atropine and scopolamine.Congenital myasthenic syndrome (CMS) is an inherited neuromuscular disorder caused by defects of several types at the neuromuscular junction. Postsynaptic defects are the most frequent cause of CMS and often result in abnormalities in nicotinic acetylcholine receptors. The majority of mutations causing CMS are found in the AChR subunits genes.COSSINS > FIRST1 = J.See also
References
{{Reflist|28em}}External links
{{Commons category|Acetylcholine receptor}}- Acetylcholine receptor: PMAP The Proteolysis Map-animation
- {{MeshName|Acetylcholine+Receptors}}
- Acetylcholine Receptor: Molecule of The Month by David Goodsell
- Acetylcholine receptors: muscarinic and nicotinic by Flavio Guzman
- www.aspet.org/uploadedFiles/Divisions_and_Chapters/ASPET_Divisions/Neuropharmacology/Content/ans-receptors-overview.ppt" title="web.archive.org/web/20131204011631www.aspet.org/uploadedFiles/Divisions_and_Chapters/ASPET_Divisions/Neuropharmacology/Content/ans-receptors-overview.ppt">ANS receptors-overview
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