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{{Short description|Mammalian protein found in Homo sapiens}}{{protein|Name=ubiquitin specific peptidase 26|caption=|image=|width=|HGNCid=13485|Symbol=USP26|AltSymbols=|EntrezGene=83844|OMIM=300309|RefSeq=NM_031907|UniProt=Q9BXU7|PDB=|ECnumber=3.1.2.15|Chromosome=X|Arm=q|Band=26.2|LocusSupplementaryData=}}USP26 is a peptidase enzyme. The USP26 gene is an X-linked gene exclusively expressed in the testis and it codes for the ubiquitin-specific protease 26.JOURNAL, Stouffs K, Lissens W, Tournaye H, Van Steirteghem A, Liebaers I, Possible role of USP26 in patients with severely impaired spermatogenesis, European Journal of Human Genetics, 13, 3, 336–40, March 2005, 15562280, 10.1038/sj.ejhg.5201335, free, The USP26 gene is found at Xq26.2 on the X-chromosome as a single exon. The enzyme that this gene encodes comprises 913 amino acid residues and it is 104 kilodalton in size, which is transcribed from a sequence of 2794 nucleotide base-pairs on the X-chromosome.JOURNAL, Liu YL, Zheng J, Mi YJ, Zhao J, Tian QB, The impacts of nineteen mutations on the enzymatic activity of USP26, Gene, 641, 292–296, January 2018, 29111204, 10.1016/j.gene.2017.10.074, The USP26 enzyme is a deubiquitinating enzyme that places a very significant role in the regulation of protein turnover during spermatogenesis. It is a testis-specific enzyme that is solely express in spermatogonia and can prevent the degradation of ubiquitinated USP26 substrates.JOURNAL, Lahav-Baratz, Shirly, Kravtsova-Ivantsiv, Yelena, Golan, Shay, Ciechanover, Aaron, January 2017, The testis-specific USP26 is a deubiquitinating enzyme of the ubiquitin ligase Mdm2, Biochemical and Biophysical Research Communications, 482, 1, 106–111, 10.1016/j.bbrc.2016.10.135, 27810359, 0006-291X, Recent research has suggested that defects in USP26 may be involved in some cases of male infertility,JOURNAL, Zhang J, Qiu SD, Li SB, Zhou DX, Tian H, Huo YW, Ge L, Zhang QY, Novel mutations in ubiquitin-specific protease 26 gene might cause spermatogenesis impairment and male infertility, Asian Journal of Andrology, 9, 6, 809–14, November 2007, 17968467, 10.1111/j.1745-7262.2007.00305.x, free, specifically Sertoli cell-only syndrome, and an absence of sperm in the ejaculate (azoospermia).JOURNAL, Ravel C, El Houate B, Chantot S, Lourenço D, Dumaine A, Rouba H, Bandyopadahyay A, Radhakrishna U, Das B, Sengupta S, Mandelbaum J, Siffroi JP, McElreavey K, Haplotypes, mutations and male fertility: the story of the testis-specific ubiquitin protease USP26, Molecular Human Reproduction, 12, 10, 643–6, October 2006, 16888075, 10.1093/molehr/gal063, free,

See also

• Male infertility

References

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External links

• {{MeshName|USP26+protein,+human}}

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