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{{for|her granddaughter Irene Doukaina Laskarina (died 1268)|Irene Doukaina Laskarina}}

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Irene Laskarina (died 1240) (, EirÄ“nÄ“ Laskarina) was Empress consort of Nicaea. She was a daughter of Theodore I Laskaris,EB1911, Theodore Lascaris, Theodore Lascaris s.v. Irene Lascaris, 23, 766, 1, emperor of Nicaea and Anna Komnene Angelina. Her maternal grandparents were Alexios III Angelos and Euphrosyne Doukaina Kamatera. Her sister, Maria Laskarina, married Béla IV of Hungary.Irene first married the general Andronikos Palaiologos, and after his death became the wife of Theodore’s designated successor, the future John III Doukas Vatatzes in 1212. They had a son, the future Theodore II Laskaris. After the latter’s birth, she fell from a horse and was so badly injured that she was unable to have any more children. She retired to a convent, taking the monastic name Eugenia, and died there in summer of 1240, some fourteen years before her husband.{{citation|arxiv=2012.00976|title=Cometary records revise Eastern Mediterranean chronology around 1240 CE|year=2021|doi=10.1093/pasj/psaa114 |last1=Murata |first1=Koji |last2=Ichikawa |first2=Kohei |last3=Fujii |first3=Yuri I. |last4=Hayakawa |first4=Hisashi |last5=Cheng |first5=Yongchao |last6=Kawamoto |first6=Yukiko |last7=Sano |first7=Hidetoshi |journal=Publications of the Astronomical Society of Japan |volume=73 |pages=197–204 }}Irene is praised by historians{{Like whom?|date=October 2023}} for her modesty and prudence and is said to have brought about by her example a considerable improvement in the morals of her nation.

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{{reflist}}{{Roman empresses|state=collapsed}}