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{{Short description|Mammalian protein found in Homo sapiens}}{{For|the surname|Corin}}{{distinguish|text=Lipoprotein receptor-related protein 4, which is also abbreviated as LRP4}}{{cs1 config |name-list-style=vanc|display-authors=6}}

factoids

Corin, also called atrial natriuretic peptide-converting enzyme, is a protein that in humans is encoded by the CORIN gene.JOURNAL, Yan W, Sheng N, Seto M, Morser J, Wu Q, Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart, The Journal of Biological Chemistry, 274, 21, 14926–14935, May 1999, 10329693, 10.1074/jbc.274.21.14926, free, WEB, Entrez Gene: CORIN corin, serine peptidase,weblink

Protein

Human corin, a polypeptide of 1042 amino acids, consists of an N-terminal cytoplasmic domain, a transmembrane domain and an extracellular region with two frizzled-like domains, eight LDL receptor-like domains, a scavenger receptor-like domain and a C-terminal trypsin-like serine protease domain.JOURNAL, Hooper JD, Scarman AL, Clarke BE, Normyle JF, Antalis TM, Localization of the mosaic transmembrane serine protease corin to heart myocytes, European Journal of Biochemistry, 267, 23, 6931–6937, December 2000, 11082206, 10.1046/j.1432-1033.2000.01806.x, free, Corin is synthesized as a zymogen that is activated by PCSK6.JOURNAL, Chen S, Cao P, Dong N, Peng J, Zhang C, Wang H, Zhou T, Yang J, Zhang Y, Martelli EE, Naga Prasad SV, Miller RE, Malfait AM, Zhou Y, Wu Q, PCSK6-mediated corin activation is essential for normal blood pressure, Nature Medicine, 21, 9, 1048–1053, September 2015, 26259032, 4710517, 10.1038/nm.3920, Corin exhibits a trypsin-like catalytic activity favoring basic residues at the P1 position.JOURNAL, Knappe S, Wu F, Masikat MR, Morser J, Wu Q, Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin, The Journal of Biological Chemistry, 278, 52, 52363–52370, December 2003, 14559895, 10.1074/jbc.M309991200, free, Human corin contains 19 N-glycosylation sites. N-glycans promote corin expression on the cell surface and protect corin from metalloproteinase-mediated shedding.JOURNAL, Liao X, Wang W, Chen S, Wu Q, Role of glycosylation in corin zymogen activation, The Journal of Biological Chemistry, 282, 38, 27728–27735, September 2007, 17660514, 10.1074/jbc.M703687200, free, JOURNAL, Gladysheva IP, King SM, Houng AK, N-glycosylation modulates the cell-surface expression and catalytic activity of corin, Biochemical and Biophysical Research Communications, 373, 1, 130–135, August 2008, 18549807, 10.1016/j.bbrc.2008.05.181, JOURNAL, Wang H, Zhou T, Peng J, Xu P, Dong N, Chen S, Wu Q, Distinct roles of N-glycosylation at different sites of corin in cell membrane targeting and ectodomain shedding, The Journal of Biological Chemistry, 290, 3, 1654–1663, January 2015, 25451932, 4340409, 10.1074/jbc.M114.606442, free,

Function

Corin converts the atrial natriuretic peptide (ANP) precursor, pro-ANP, to mature ANP, a cardiac hormone that regulates salt-water balance and blood pressure.JOURNAL, Yan W, Wu F, Morser J, Wu Q, Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme, Proceedings of the National Academy of Sciences of the United States of America, 97, 15, 8525–8529, July 2000, 10880574, 26981, 10.1073/pnas.150149097, free, 2000PNAS...97.8525Y, In mice, corin deficiency prevents pro-ANP processing and causes salt-sensitive hypertension.JOURNAL, Chan JC, Knudson O, Wu F, Morser J, Dole WP, Wu Q, Hypertension in mice lacking the proatrial natriuretic peptide convertase corin, Proceedings of the National Academy of Sciences of the United States of America, 102, 3, 785–790, January 2005, 15637153, 545541, 10.1073/pnas.0407234102, free, 2005PNAS..102..785C, JOURNAL, Wang W, Shen J, Cui Y, Jiang J, Chen S, Peng J, Wu Q, Impaired sodium excretion and salt-sensitive hypertension in corin-deficient mice, Kidney International, 82, 1, 26–33, July 2012, 22418978, 3376235, 10.1038/ki.2012.41, Corin may also function as a pro-brain-type natriuretic peptide convertase.JOURNAL, Semenov AG, Tamm NN, Seferian KR, Postnikov AB, Karpova NS, Serebryanaya DV, Koshkina EV, Krasnoselsky MI, Katrukha AG, Processing of pro-B-type natriuretic peptide: furin and corin as candidate convertases, Clinical Chemistry, 56, 7, 1166–1176, July 2010, 20489134, 10.1373/clinchem.2010.143883, free, JOURNAL, Ichiki T, Huntley BK, Burnett JC, BNP molecular forms and processing by the cardiac serine protease corin, Advances in Clinical Chemistry, 61, 1–31, 2013, 24015598, 4522930, 10.1016/b978-0-12-407680-8.00001-4, 9780124076808, Corin-mediated ANP production in the pregnant uterus promotes spiral artery remodeling and trophoblast invasion.JOURNAL, Cui Y, Wang W, Dong N, Lou J, Srinivasan DK, Cheng W, Huang X, Liu M, Fang C, Peng J, Chen S, Wu S, Liu Z, Dong L, Zhou Y, Wu Q, Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy, Nature, 484, 7393, 246–250, March 2012, 22437503, 3578422, 10.1038/nature10897, 2012Natur.484..246C, CORIN mutations have been reported in patients with preeclampsia.JOURNAL, Dong N, Zhou T, Zhang Y, Liu M, Li H, Huang X, Liu Z, Wu Y, Fukuda K, Qin J, Wu Q, Corin mutations K317E and S472G from preeclamptic patients alter zymogen activation and cell surface targeting. [Corrected], The Journal of Biological Chemistry, 289, 25, 17909–17916, June 2014, 24828501, 4067221, 10.1074/jbc.M114.551424, free, In mice, corin functions in the dermal papilla to regulate coat color in an Agouti-dependent pathway.JOURNAL, Enshell-Seijffers D, Lindon C, Morgan BA, The serine protease Corin is a novel modifier of the Agouti pathway, Development, 135, 2, 217–225, January 2008, 18057101, 2186067, 10.1242/dev.011031,

Variants and mutations

Variants encoded by alternative exons were reported in human and mouse corin.JOURNAL, Qi X, Jiang J, Zhu M, Wu Q, Human corin isoforms with different cytoplasmic tails that alter cell surface targeting, The Journal of Biological Chemistry, 286, 23, 20963–20969, June 2011, 21518754, 3121476, 10.1074/jbc.M110.217570, free, A variant allele (T555I/Q568P) was found in African Americans with hypertension and cardiac hypertrophy.JOURNAL, Dries DL, Victor RG, Rame JE, Cooper RS, Wu X, Zhu X, Leonard D, Ho SI, Wu Q, Post W, Drazner MH, Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension, Circulation, 112, 16, 2403–2410, October 2005, 16216958, 10.1161/CIRCULATIONAHA.105.568881, free, JOURNAL, Rame JE, Drazner MH, Post W, Peshock R, Lima J, Cooper RS, Dries DL, Corin I555(P568) allele is associated with enhanced cardiac hypertrophic response to increased systemic afterload, Hypertension, 49, 4, 857–864, April 2007, 17296875, 10.1161/01.HYP.0000258566.95867.9e, free, The amino acid substitutions impaired corin activity.JOURNAL, Wang W, Liao X, Fukuda K, Knappe S, Wu F, Dries DL, Qin J, Wu Q, Corin variant associated with hypertension and cardiac hypertrophy exhibits impaired zymogen activation and natriuretic peptide processing activity, Circulation Research, 103, 5, 502–508, August 2008, 18669922, 2652846, 10.1161/CIRCRESAHA.108.177352, JOURNAL, Wang W, Cui Y, Shen J, Jiang J, Chen S, Peng J, Wu Q, Salt-sensitive hypertension and cardiac hypertrophy in transgenic mice expressing a corin variant identified in blacks, Hypertension, 60, 5, 1352–1358, November 2012, 22987923, 3475733, 10.1161/HYPERTENSIONAHA.112.201244, An insertion variant in exon 1 alters the cytoplasmic tail.JOURNAL, Zhang Y, Li H, Zhou J, Wang A, Yang J, Wang C, Liu M, Zhou T, Zhu L, Zhang Y, Dong N, Wu Q, A corin variant identified in hypertensive patients that alters cytoplasmic tail and reduces cell surface expression and activity, Scientific Reports, 4, 7378, December 2014, 25488193, 4260221, 10.1038/srep07378, 2014NatSR...4E7378Z, This variant appeared more frequently in hypertensive patients. CORIN mutations were found in patients with hypertension.JOURNAL, Baris Feldman H, Chai Gadot C, Zahler D, Mory A, Aviram G, Elhanan E, Shefer G, Goldiner I, Amir Y, Kurolap A, Ablin JN, Corin and Left Atrial Cardiomyopathy, Hypertension, Arrhythmia, and Fibrosis, The New England Journal of Medicine, 389, 18, 1685–1692, November 2023, 37913506, 10.1056/NEJMoa2301908, 264931773, JOURNAL, Dong N, Fang C, Jiang Y, Zhou T, Liu M, Zhou J, Shen J, Fukuda K, Qin J, Wu Q, Corin mutation R539C from hypertensive patients impairs zymogen activation and generates an inactive alternative ectodomain fragment, The Journal of Biological Chemistry, 288, 11, 7867–7874, March 2013, 23372161, 3597824, 10.1074/jbc.M112.411512, free,

References

{{reflist|33em}}

Further reading

• JOURNAL, Yan W, Wu F, Morser J, Wu Q, Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme, Proceedings of the National Academy of Sciences of the United States of America, 97, 15, 8525–8529, July 2000, 10880574, 26981, 10.1073/pnas.150149097, free, 2000PNAS...97.8525Y,
• JOURNAL, Hooper JD, Scarman AL, Clarke BE, Normyle JF, Antalis TM, Localization of the mosaic transmembrane serine protease corin to heart myocytes, European Journal of Biochemistry, 267, 23, 6931–6937, December 2000, 11082206, 10.1046/j.1432-1033.2000.01806.x, free,
• JOURNAL, Wu F, Yan W, Pan J, Morser J, Wu Q, Processing of pro-atrial natriuretic peptide by corin in cardiac myocytes, The Journal of Biological Chemistry, 277, 19, 16900–16905, May 2002, 11884416, 10.1074/jbc.M201503200, free,
• JOURNAL, Pan J, Hinzmann B, Yan W, Wu F, Morser J, Wu Q, Genomic structures of the human and murine corin genes and functional GATA elements in their promoters, The Journal of Biological Chemistry, 277, 41, 38390–38398, October 2002, 12154094, 10.1074/jbc.M205686200, free,
• JOURNAL, Knappe S, Wu F, Masikat MR, Morser J, Wu Q, Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin, The Journal of Biological Chemistry, 278, 52, 52363–52370, December 2003, 14559895, 10.1074/jbc.M309991200, free,
• JOURNAL, Knappe S, Wu F, Madlansacay MR, Wu Q, Identification of domain structures in the propeptide of corin essential for the processing of proatrial natriuretic peptide, The Journal of Biological Chemistry, 279, 33, 34464–34471, August 2004, 15192093, 10.1074/jbc.M405041200, free,
• JOURNAL, Dries DL, Victor RG, Rame JE, Cooper RS, Wu X, Zhu X, Leonard D, Ho SI, Wu Q, Post W, Drazner MH, Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension, Circulation, 112, 16, 2403–2410, October 2005, 16216958, 10.1161/CIRCULATIONAHA.105.568881, free,
• JOURNAL, Rame JE, Drazner MH, Post W, Peshock R, Lima J, Cooper RS, Dries DL, Corin I555(P568) allele is associated with enhanced cardiac hypertrophic response to increased systemic afterload, Hypertension, 49, 4, 857–864, April 2007, 17296875, 10.1161/01.HYP.0000258566.95867.9e, free,
• JOURNAL, Wu Q, The serine protease corin in cardiovascular biology and disease, Frontiers in Bioscience, 12, 8–12, 4179–4190, May 2007, 17485366, 10.2741/2379, free,
• JOURNAL, Liao X, Wang W, Chen S, Wu Q, Role of glycosylation in corin zymogen activation, The Journal of Biological Chemistry, 282, 38, 27728–27735, September 2007, 17660514, 10.1074/jbc.M703687200, free,
• JOURNAL, Wu Q, Xu-Cai YO, Chen S, Wang W, Corin: new insights into the natriuretic peptide system, Kidney International, 75, 2, 142–146, January 2009, 18716601, 2655200, 10.1038/ki.2008.418,
• JOURNAL, Peleg A, Jaffe AS, Hasin Y, Enzyme-linked immunoabsorbent assay for detection of human serine protease corin in blood, Clinica Chimica Acta; International Journal of Clinical Chemistry, 409, 1–2, 85–89, November 2009, 19751717, 10.1016/j.cca.2009.09.004,
• JOURNAL, Dries DL, Process matters: Emerging concepts underlying impaired natriuretic peptide system function in heart failure, Circulation. Heart Failure, 4, 2, 107–110, March 2011, 21406676, 10.1161/CIRCHEARTFAILURE.111.960948, free,
• JOURNAL, Zhou Y, Wu Q, Role of corin and atrial natriuretic peptide in preeclampsia, Placenta, 34, 2, 89–94, February 2013, 23211473, 3563874, 10.1016/j.placenta.2012.11.016,
• JOURNAL, Armaly Z, Assady S, Abassi Z, Corin: a new player in the regulation of salt-water balance and blood pressure, Current Opinion in Nephrology and Hypertension, 22, 6, 713–722, November 2013, 24100222, 10.1097/01.mnh.0000435609.35789.32, 34150725,
• JOURNAL, Zhou Y, Wu Q, Corin in natriuretic peptide processing and hypertension, Current Hypertension Reports, 16, 2, 415, February 2014, 24407448, 3941447, 10.1007/s11906-013-0415-7,

External links

• {{UCSC gene info|CORIN}}