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{{Other uses}}{{Redirect|Fertilized egg|the food product|Balut (egg)}}

{{Human growth and development}}A zygote (from Greek ζυγωτός zygōtos "joined" or "yoked", from ζυγοῦν zygoun "to join" or "to yoke")WEB,weblink English etymology of zygote,, no,weblink" title="">weblink 2017-03-30, is a eukaryotic cell formed by a fertilization event between two gametes. The zygote's genome is a combination of the DNA in each gamete, and contains all of the genetic information necessary to form a new individual. In multicellular organisms, the zygote is the earliest developmental stage. In single-celled organisms, the zygote can divide asexually by mitosis to produce identical offspring.Oscar Hertwig and Richard Hertwig made some of the first discoveries on animal zygote formation.


In fungi, the sexual fusion of haploid cells is called karyogamy. The result of karyogamy is the formation of a diploid cell called the zygote or zygospore. This cell may then enter meiosis or mitosis depending on the life cycle of the species.


In plants, the zygote may be polyploid if fertilization occurs between meiotically unreduced gametes.In land plants, the zygote is formed within a chamber called the archegonium. In seedless plants, the archegonium is usually flask-shaped, with a long hollow neck through which the sperm cell enters. As the zygote divides and grows, it does so inside the archegonium.


Main articles: Development of the human body, Human fertilizationIn human fertilization, a released ovum (a haploid secondary oocyte with replicate chromosome copies) and a haploid sperm cell (male gamete)—combine to form a single 2n diploid cell called the zygote. Once the single sperm enters the oocyte, it completes the division of the second meiosis forming a haploid daughter with only 23 chromosomes, almost all of the cytoplasm, and the sperm in its own pronucleus. The other product of meiosis is the second polar body with only chromosomes but no ability to replicate or survive. In the fertilized daughter, DNA is then replicated in the two separate pronuclei derived from the sperm and ovum, making the zygote's chromosome number temporarily 4n diploid. After approximately 30 hours from the time of fertilization, fusion of the pronuclei and immediate mitotic division produce two 2n diploid daughter cells called blastomeres.Blastomere Encyclopædia Britannica {{webarchive|url= |date=2013-09-28 }}. Encyclopædia Britannica Online. Encyclopædia Britannica Inc., 2012. Web. 06 Feb. 2012.Between the stages of fertilization and implantation, the developing human is a preimplantation conceptus. There is some dispute about whether this conceptus should no longer be referred to as an embryo, but should now be referred to as a proembryo, which is terminology that traditionally has been used to refer to plant life. Some ethicist and legal scholars make the argument that it is incorrect to call the conceptus an embryo, because it will later differentiate into both intraembryonic and extraembryonic tissues,Larsen's Human Embryology. 4th Ed. Page 4. and can even split to produce multiple embryos (identical twins). Others have pointed out that so-called extraembryonic tissues are really part of the embryo's body that are no longer used after birth (much as milk teeth fall out after childhood). Further, as the embryo splits to form identical twins – leaving the original tissues intact – new embryos are generated, in a process similar to that of cloning an adult human.JOURNAL, Condic, Maureen L., Totipotency: What It Is And What It Is Not, Stem Cells and Development, 14 April 2014, 3991987, 24368070, 10.1089/scd.2013.0364, 23, 8, 796–812, In the US the National Institutes of Health has determined that the traditional classification of pre-implantation embryo is still correct.WEB,weblink Archived copy, 2009-02-17, yes,weblink" title="">weblink 2009-01-30, After fertilization, the conceptus travels down the oviduct towards the uterus while continuing to divideO’Reilly, Deirdre. "Fetal development {{webarchive|url= |date=2011-10-27 }}". MedlinePlus Medical Encyclopedia (2007-10-19). Retrieved 2009-02-15. mitotically without actually increasing in size, in a process called cleavage.Klossner, N. Jayne and Hatfield, Nancy. Introductory Maternity & Pediatric Nursing, p. 107 (Lippincott Williams & Wilkins, 2006). After four divisions, the conceptus consists of 16 blastomeres, and it is known as the morula.Neas, John F. "Human Development" {{webarchive |url= |date=July 22, 2011 }}. Embryology Atlas Through the processes of compaction, cell division, and blastulation, the conceptus takes the form of the blastocyst by the fifth day of development, just as it approaches the site of implantation.Blackburn, Susan. Maternal, Fetal, & Neonatal Physiology, p. 80 (Elsevier Health Sciences 2007). When the blastocyst hatches from the zona pellucida, it can implant in the endometrial lining of the uterus and begin the embryonic stage of development.The human zygote has been genetically edited in experiments designed to cure inherited diseases.Human zygote edited genetically {{webarchive|url= |date=2015-05-18 }}

Reprogramming to totipotency

The formation of a totipotent zygote with the potential to produce a whole organism depends on epigenetic reprogramming. DNA demethylation of the paternal genome in the zygote appears to be an important part of epigenetic reprogramming.JOURNAL, Ladstätter S, Tachibana-Konwalski K, A Surveillance Mechanism Ensures Repair of DNA Lesions during Zygotic Reprogramming, Cell, 167, 7, 1774–1787.e13, December 2016, 27916276, 5161750, 10.1016/j.cell.2016.11.009, In the paternal genome of the mouse, demethylation of DNA, particularly at sites of methylated cytosines, is likely a key process in establishing totipotency. Demethylation involves the processes of base excision repair and possibly other DNA- repair- based mechanisms.

In other species

A Chlamydomonas zygote contains chloroplast DNA (cpDNA) from both parents; such cells are generally rare, since normally cpDNA is inherited uniparentally from the mt+ mating type parent. These rare biparental zygotes allowed mapping of chloroplast genes by recombination.

In protozoa

In the amoeba, reproduction occurs by cell division of the parent cell: first the nucleus of the parent divides into two and then the cell membrane also cleaves, becoming two "daughter" Amoebae.

See also


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