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{{Distinguish|Diabetes insipidus}}{{short description|a disease characterized by long-term high blood sugar}}

| image = Blue circle for diabetes.svg| image_size = 200px| alt = A hollow circle with a thick blue border and a clear centreDATE=17 MARCH 2006 DEADURL=YES ARCHIVE-DATE=5 AUGUST 2007, | field = Endocrinologypolyuria>Frequent urination, polydipsia, polyphagia>increased hungerDiabetic ketoacidosis, hyperosmolar hyperglycemic state, heart disease, stroke, chronic renal failure>chronic kidney failure, diabetic foot ulcer, diabetic gastroparesis>gastroparesisKRISHNASAMY >FIRST1=S FIRST2=TL JOURNAL=DIABETES THERAPY : RESEARCH, TREATMENT AND EDUCATION OF DIABETES AND RELATED DISORDERS VOLUME=9 PAGES=1-42 PMID=29934758, | onset =| duration =| types =| causes =Type 1: Family historyCHIANG JL, KIRKMAN MS, LAFFEL LM, PETERS AL JOURNAL = DIABETES CARE ISSUE = 7 DATE = JULY 2014 PMC = 5865481 Type 2: Obesity, lack of exercise, Heredity>geneticsCAUSES OF DIABETES>URL=HTTP://WWW.NIDDK.NIH.GOV/HEALTH-INFORMATION/HEALTH-TOPICS/DIABETES/CAUSES-DIABETES/PAGES/INDEX.ASPXACCESS-DATE=10 FEBRUARY 2016DEAD-URL=NO ARCHIVE-URL=HTTPS://WEB.ARCHIVE.ORG/WEB/20160202083725/HTTP://WWW.NIDDK.NIH.GOV/HEALTH-INFORMATION/HEALTH-TOPICS/DIABETES/CAUSES-DIABETES/PAGES/INDEX.ASPX, | diagnosis = High blood sugar| differential =| prevention =| treatment = Healthy diet, physical exerciseInsulin, anti-diabetic medication like metforminHTTPS://WWW.MSDMANUALS.COM/PROFESSIONAL/ENDOCRINE-AND-METABOLIC-DISORDERS/DIABETES-MELLITUS-AND-DISORDERS-OF-CARBOHYDRATE-METABOLISM/DRUG-TREATMENT-OF-DIABETES-MELLITUS FIRST=ERIKA F. DATE=FEBRUARY 2017, 12 October 2018, | prognosis =| frequency = 425 million (8.8%)| deaths = 3.2–5.0 million per year}}Diabetes mellitus (DM), commonly known as diabetes, is a group of metabolic disorders characterized by high blood sugar levels over a prolonged period.WEB, About diabetes,weblink World Health Organization, 4 April 2014, yes,weblink" title="">weblink 31 March 2014, Symptoms of high blood sugar include frequent urination, increased thirst, and increased hunger. If left untreated, diabetes can cause many complications. Acute complications can include diabetic ketoacidosis, hyperosmolar hyperglycemic state, or death.JOURNAL, Kitabchi AE, Umpierrez GE, Miles JM, Fisher JN, Hyperglycemic crises in adult patients with diabetes, Diabetes Care, 32, 7, 1335–43, July 2009, 19564476, 2699725, 10.2337/dc09-9032, Serious long-term complications include cardiovascular disease, stroke, chronic kidney disease, foot ulcers, and damage to the eyes.Diabetes is due to either the pancreas not producing enough insulin, or the cells of the body not responding properly to the insulin produced.BOOK, Shoback DG, Gardner D, Greenspan's basic & clinical endocrinology, 2011, McGraw-Hill Medical, New York, 978-0-07-162243-1, Chapter 17, 9th, There are three main types of diabetes mellitus:
  • Type 1 DM results from the pancreas's failure to produce enough insulin due to loss of beta cells. This form was previously referred to as "insulin-dependent diabetes mellitus" (IDDM) or "juvenile diabetes". The cause is unknown.
  • Type 2 DM begins with insulin resistance, a condition in which cells fail to respond to insulin properly. As the disease progresses, a lack of insulin may also develop.BOOK, RSSDI textbook of diabetes mellitus, 2012, Jaypee Brothers Medical Publishers, 978-93-5025-489-9, 235, Rev. 2nd,weblink no,weblink 14 October 2015, This form was previously referred to as "non insulin-dependent diabetes mellitus" (NIDDM) or "adult-onset diabetes". The most common cause is a combination of excessive body weight and insufficient exercise.
  • Gestational diabetes is the third main form, and occurs when pregnant women without a previous history of diabetes develop high blood sugar levels.
Prevention and treatment involve maintaining a healthy diet, regular physical exercise, a normal body weight, and avoiding use of tobacco. Control of blood pressure and maintaining proper foot care are important for people with the disease. Type 1 DM must be managed with insulin injections.WEB, Diabetes Fact sheet N°312,weblink WHO, 25 March 2014, October 2013,weblink" title="">weblink 26 August 2013, Type 2 DM may be treated with medications with or without insulin.WEB, The top 10 causes of death Fact sheet N°310,weblink World Health Organization, October 2013, no,weblink" title="">weblink 30 May 2017, Insulin and some oral medications can cause low blood sugar.BOOK, Rippe RS, Irwin JM, Manual of intensive care medicine, 2010, Wolters Kluwer Health/Lippincott Williams & Wilkins, 978-0-7817-9992-8, 549, 5th, Weight loss surgery in those with obesity is sometimes an effective measure in those with type 2 DM.JOURNAL, Picot J, Jones J, Colquitt JL, Gospodarevskaya E, Loveman E, Baxter L, Clegg AJ, The clinical effectiveness and cost-effectiveness of bariatric (weight loss) surgery for obesity: a systematic review and economic evaluation, Health Technology Assessment, 13, 41, 1–190, 215–357, iii–iv, September 2009, 19726018, 10.3310/hta13410, Gestational diabetes usually resolves after the birth of the baby.BOOK, Cash, Jill, Family Practice Guidelines, 2014, Springer, 978-0-8261-6875-7, 396, 3rd,weblink no,weblink 31 October 2015, {{asof|2017}}, an estimated 425 million people had diabetes worldwide,BOOK, International Diabetes Federation, IDF Diabetes Atlas, 8th edn., 2017, Brussels, Belgium: International Diabetes Federation,weblink with type 2 DM making up about 90% of the cases.BOOK, Williams textbook of endocrinology, Elsevier/Saunders, 978-1-4377-0324-5, 1371–1435, 12th, 2011, JOURNAL, Shi Y, Hu FB, The global implications of diabetes and cancer, Lancet, 383, 9933, 1947–48, June 2014, 24910221, 10.1016/S0140-6736(14)60886-2,weblink This represents 8.8% of the adult population, with equal rates in both women and men. Trend suggests that rates will continue to rise. Diabetes at least doubles a person's risk of early death. In 2017, diabetes resulted in approximately 3.2 to 5.0 million deaths. The global economic cost of diabetes related health expenditure in 2017 was estimated at {{USD|727}} billion. In the United States, diabetes cost nearly {{USD|245}} billion in 2012.JOURNAL, Economic costs of diabetes in the U.S. in 2012, Diabetes Care, 36, 4, 1033–46, April 2013, 23468086, 3609540, 10.2337/dc12-2625, {{TOC limit}}

Signs and symptoms

(File:Main symptoms of diabetes.svg|thumb|upright=1.5|Overview of the most significant symptoms of diabetes)The classic symptoms of untreated diabetes are unintended weight loss, polyuria (increased urination), polydipsia (increased thirst), and polyphagia (increased hunger).JOURNAL, Cooke DW, Plotnick L, Type 1 diabetes mellitus in pediatrics, Pediatrics in Review, 29, 11, 374–84; quiz 385, November 2008, 18977856, 10.1542/pir.29-11-374, Symptoms may develop rapidly (weeks or months) in type 1 DM, while they usually develop much more slowly and may be subtle or absent in type 2 DM. Other symptoms of diabetes mellitus include weight loss and tiredness.WEB,weblink WHO {{!, Diabetes mellitus|website=WHO|access-date=2019-03-23}}Several other signs and symptoms can mark the onset of diabetes although they are not specific to the disease. In addition to the known ones above, they include blurred vision, headache, fatigue, slow healing of cuts, and itchy skin. Prolonged high blood glucose can cause glucose absorption in the lens of the eye, which leads to changes in its shape, resulting in vision changes. Long-term vision loss can also be caused by diabetic retinopathy. A number of skin rashes that can occur in diabetes are collectively known as diabetic dermadromes.BOOK,weblink Diabetes: Symptoms, Causes, Treatment and Prevention, Rockefeller, J.D., 2015, 978-1-5146-0305-5, en,

Diabetic emergencies

People (usually with type 1 DM) may also experience episodes of diabetic ketoacidosis (DKA), a metabolic disturbance characterized by nausea, vomiting and abdominal pain, the smell of acetone on the breath, deep breathing known as Kussmaul breathing, and in severe cases a decreased level of consciousness.JOURNAL, Kitabchi AE, Umpierrez GE, Miles JM, Fisher JN, Hyperglycemic crises in adult patients with diabetes, Diabetes Care, 32, 7, 1335–43, July 2009, 19564476, 2699725, 10.2337/dc09-9032,weblinkweblink" title="">weblink no, 2016-06-25, A rare but equally severe possibility is hyperosmolar hyperglycemic state (HHS), which is more common in type 2 DM and is mainly the result of dehydration.Treatment-related low blood sugar (hypoglycemia) is common in people with type 1 and also type 2 DM depending on the medication being used. Most cases are mild and are not considered medical emergencies. Effects can range from feelings of unease, sweating, trembling, and increased appetite in mild cases to more serious effects such as confusion, changes in behavior such as aggressiveness, seizures, unconsciousness, and (rarely) permanent brain damage or death in severe cases.JOURNAL, Kenny C, When hypoglycemia is not obvious: diagnosing and treating under-recognized and undisclosed hypoglycemia, Primary Care Diabetes, 8, 1, 3–11, April 2014, 24100231, 10.1016/j.pcd.2013.09.002,weblink JOURNAL, Verrotti A, Scaparrotta A, Olivieri C, Chiarelli F, Seizures and type 1 diabetes mellitus: current state of knowledge, European Journal of Endocrinology, 167, 6, 749–58, December 2012, 22956556, 10.1530/EJE-12-0699, rapid breathing and sweating, cold, pale skin are characteristic of low blood sugar but not definitive.WEB, Symptoms of Low Blood Sugar,weblink WebMD, 29 June 2016, no,weblink" title="">weblink 18 June 2016, {{medrs|date=May 2019}} Mild to moderate cases are self-treated by eating or drinking something high in sugar. Severe cases can lead to unconsciousness and must be treated with intravenous glucose or injections with glucagon.NEWS,weblink Glucagon–Injection side effects, medical uses, and drug interactions., MedicineNet, 2018-02-05, en, {{medrs|date=May 2019}}


(File:Diabetes complications.jpg|thumb|Retinopathy, nephropathy, and neuropathy are potential complications of diabetes)All forms of diabetes increase the risk of long-term complications. These typically develop after many years (10–20) but may be the first symptom in those who have otherwise not received a diagnosis before that time.The major long-term complications relate to damage to blood vessels. Diabetes doubles the risk of cardiovascular diseaseJOURNAL, Sarwar N, Gao P, Seshasai SR, Gobin R, Kaptoge S, Di Angelantonio E, Ingelsson E, Lawlor DA, Selvin E, Stampfer M, Stehouwer CD, Lewington S, Pennells L, Thompson A, Sattar N, White IR, Ray KK, Danesh J, Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies, Lancet, 375, 9733, 2215–22, June 2010, 20609967, 2904878, 10.1016/S0140-6736(10)60484-9, and about 75% of deaths in diabetics are due to coronary artery disease.JOURNAL, O'Gara PT, Kushner FG, Ascheim DD, Casey DE, Chung MK, de Lemos JA, Ettinger SM, Fang JC, Fesmire FM, Franklin BA, Granger CB, Krumholz HM, Linderbaum JA, Morrow DA, Newby LK, Ornato JP, Ou N, Radford MJ, Tamis-Holland JE, Tommaso CL, Tracy CM, Woo YJ, Zhao DX, Anderson JL, Jacobs AK, Halperin JL, Albert NM, Brindis RG, Creager MA, DeMets D, Guyton RA, Hochman JS, Kovacs RJ, Kushner FG, Ohman EM, Stevenson WG, Yancy CW, 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, Circulation, 127, 4, e362–425, January 2013, 23247304, 10.1161/CIR.0b013e3182742cf6, Other macrovascular diseases include stroke, and peripheral artery disease.The primary complications of diabetes due to damage in small blood vessels include damage to the eyes, kidneys, and nerves.WEB, Diabetes Programme,weblink World Health Organization, 22 April 2014, no,weblink" title="">weblink 26 April 2014, Damage to the eyes, known as diabetic retinopathy, is caused by damage to the blood vessels in the retina of the eye, and can result in gradual vision loss and eventual blindness. Diabetes also increases the risk of having glaucoma, cataracts, and other eye problems. It is recommended that diabetics visit an eye doctor once a year.WEB,weblink Diabetes – eye care: MedlinePlus Medical Encyclopedia,, en, 2018-03-27, Damage to the kidneys, known as diabetic nephropathy, can lead to tissue scarring, urine protein loss, and eventually chronic kidney disease, sometimes requiring dialysis or kidney transplantation. Damage to the nerves of the body, known as diabetic neuropathy, is the most common complication of diabetes. The symptoms can include numbness, tingling, pain, and altered pain sensation, which can lead to damage to the skin. Diabetes-related foot problems (such as diabetic foot ulcers) may occur, and can be difficult to treat, occasionally requiring amputation. Additionally, proximal diabetic neuropathy causes painful muscle atrophy and weakness.There is a link between cognitive deficit and diabetes. Compared to those without diabetes, those with the disease have a 1.2 to 1.5-fold greater rate of decline in cognitive function.JOURNAL, Cognitive decline and dementia in diabetes – systematic overview of prospective observational studies, Diabetologia, 48, 12, 2460–69, 8 Nov 2005, Cukierman, T, 10.1007/s00125-005-0023-4, 16283246, Being diabetic, especially when on insulin, increases the risk of falls in older people.JOURNAL, Yang Y, Hu X, Zhang Q, Zou R, Diabetes mellitus and risk of falls in older adults: a systematic review and meta-analysis, Age and Ageing, 45, 6, 761–67, November 2016, 27515679, 10.1093/ageing/afw140,

Causes{| class"wikitable" style"float:right; margin:10px"|+ Comparison of type 1 and 2 diabetes

! Feature !! Type 1 diabetes !! Type 2 diabetes! Onset|Gradual! Age at onset| Mostly in adults! Body size JOURNAL = MEDICINE PAGES = 1–5 DOI = 10.1383/MEDC., Often obese! Ketoacidosis| Rare! Autoantibodies| Absent! Endogenous insulin| Normal, decreased or increased! Concordance in identical twins| 90%! Prevalence| ~90%Diabetes mellitus is classified into four broad categories: type 1, type 2, gestational diabetes, and "other specific types". The "other specific types" are a collection of a few dozen individual causes. Diabetes is a more variable disease than once thought and people may have combinations of forms.JOURNAL, Tuomi T, Santoro N, Caprio S, Cai M, Weng J, Groop L, The many faces of diabetes: a disease with increasing heterogeneity, Lancet, 383, 9922, 1084–94, March 2014, 24315621, 10.1016/S0140-6736(13)62219-9, The term "diabetes", without qualification, usually refers to diabetes mellitus.

Type 1

Type 1 diabetes mellitus is characterized by loss of the insulin-producing beta cells of the pancreatic islets, leading to insulin deficiency. This type can be further classified as immune-mediated or idiopathic. The majority of type 1 diabetes is of the immune-mediated nature, in which a T cell-mediated autoimmune attack leads to the loss of beta cells and thus insulin.JOURNAL, Rother KI, Diabetes treatment--bridging the divide, The New England Journal of Medicine, 356, 15, 1499–501, April 2007, 17429082, 4152979, 10.1056/NEJMp078030, It causes approximately 10% of diabetes mellitus cases in North America and Europe. Most affected people are otherwise healthy and of a healthy weight when onset occurs. Sensitivity and responsiveness to insulin are usually normal, especially in the early stages. Although it has been called “juvenile diabetes” due to the frequent onset in children, the majority of individuals living with type 1 diabetes are now adults.JOURNAL, Chiang JL, Kirkman MS, Laffel LM, Peters AL, Type 1 diabetes through the life span: a position statement of the American Diabetes Association, Diabetes Care, 37, 7, 2034–54, July 2014, 24935775, 5865481, 10.2337/dc14-1140, "Brittle" diabetes, also known as unstable diabetes or labile diabetes, is a term that was traditionally used to describe the dramatic and recurrent swings in glucose levels, often occurring for no apparent reason in insulin-dependent diabetes. This term, however, has no biologic basis and should not be used.WEB,weblink Diabetes Mellitus (DM): Diabetes Mellitus and Disorders of Carbohydrate Metabolism: Merck Manual Professional, Merck & Co., Merck Publishing, April 2010, 2010-07-30, no,weblink" title="">weblink 2010-07-28, Still, type 1 diabetes can be accompanied by irregular and unpredictable high blood sugar levels, frequently with ketosis, and sometimes with serious low blood sugar levels. Other complications include an impaired counterregulatory response to low blood sugar, infection, gastroparesis (which leads to erratic absorption of dietary carbohydrates), and endocrinopathies (e.g., Addison's disease). These phenomena are believed to occur no more frequently than in 1% to 2% of persons with type 1 diabetes.JOURNAL, Dorner M, Pinget M, Brogard JM, [Essential labile diabetes (author's transl)], German, MMW, Munchener Medizinische Wochenschrift, 119, 19, 671–74, May 1977, 406527, (File:Type 1 Diabetes Mellitus.jpg|thumb|Autoimmune attack in type 1 diabetes.)Type 1 diabetes is partly inherited, with multiple genes, including certain HLA genotypes, known to influence the risk of diabetes. In genetically susceptible people, the onset of diabetes can be triggered by one or more environmental factors,JOURNAL, Petzold A, Solimena M, Knoch KP, Mechanisms of Beta Cell Dysfunction Associated With Viral Infection, Current Diabetes Reports, 15, 10, 73, October 2015, 26280364, 4539350, 10.1007/s11892-015-0654-x, Review, So far, none of the hypotheses accounting for virus-induced beta cell autoimmunity has been supported by stringent evidence in humans, and the involvement of several mechanisms rather than just one is also plausible., such as a viral infection or diet. Several viruses have been implicated, but to date there is no stringent evidence to support this hypothesis in humans.JOURNAL, Butalia S, Kaplan GG, Khokhar B, Rabi DM, Environmental Risk Factors and Type 1 Diabetes: Past, Present, and Future, Canadian Journal of Diabetes, 40, 6, 586–93, December 2016, 27545597, 10.1016/j.jcjd.2016.05.002, Review, Among dietary factors, data suggest that gliadin (a protein present in gluten) may play a role in the development of type 1 diabetes, but the mechanism is not fully understood.JOURNAL, Serena G, Camhi S, Sturgeon C, Yan S, Fasano A, The Role of Gluten in Celiac Disease and Type 1 Diabetes, Nutrients, 7, 9, 7143–62, August 2015, 26343710, 4586524, 10.3390/nu7095329, {{open access}}JOURNAL, Visser J, Rozing J, Sapone A, Lammers K, Fasano A, Tight junctions, intestinal permeability, and autoimmunity: celiac disease and type 1 diabetes paradigms, Annals of the New York Academy of Sciences, 1165, 1, 195–205, May 2009, 19538307, 2886850, 10.1111/j.1749-6632.2009.04037.x, 2009NYASA1165..195V, Type 1 diabetes can occur at any age, and a significant proportion is diagnosed during adulthood. Latent autoimmune diabetes of adults (LADA) is the diagnostic term applied when type 1 DM develops in adults; it has a slower onset than the same condition in children. Given this difference, some use the unofficial term "type 1.5 diabetes" for this condition. Adults with LADA are frequently initially misdiagnosed as having type 2 DM, based on age rather than causeJOURNAL, Laugesen E, Østergaard JA, Leslie RD, Latent autoimmune diabetes of the adult: current knowledge and uncertainty, Diabetic Medicine, 32, 7, 843–52, July 2015, 25601320, 4676295, 10.1111/dme.12700,

Type 2

(File:Type 2 Diabetes Mellitus.jpg|thumb|Reduced insulin secretion and absorption leads to high glucose content in the blood.)Type 2 DM is characterized by insulin resistance, which may be combined with relatively reduced insulin secretion. The defective responsiveness of body tissues to insulin is believed to involve the insulin receptor. However, the specific defects are not known. Diabetes mellitus cases due to a known defect are classified separately. Type 2 DM is the most common type of diabetes mellitus. Many people with type 2 diabetes have evidence of "prediabetes" (impaired fasting glucose and/or impaired glucose tolerance) for many years before meeting the criteria for type 2 diabetes.{{citation needed|date=May 2019}} Prediabetes and easy overt type 2 diabetes can be reversed by a variety of measures and medications that improve insulin sensitivity or reduce the liver's glucose production.{{citation needed|date=May 2019}}Type 2 DM is primarily due to lifestyle factors and genetics.JOURNAL, Risérus U, Willett WC, Hu FB, Dietary fats and prevention of type 2 diabetes, Progress in Lipid Research, 48, 1, 44–51, January 2009, 19032965, 2654180, 10.1016/j.plipres.2008.10.002, A number of lifestyle factors are known to be important to the development of type 2 DM, including obesity (defined by a body mass index of greater than 30), lack of physical activity, poor diet, stress, and urbanization. Excess body fat is associated with 30% of cases in those of Chinese and Japanese descent, 60–80% of cases in those of European and African descent, and 100% of Pima Indians and Pacific Islanders. Even those who are not obese often have a high waist–hip ratio.Dietary factors also influence the risk of developing type 2 DM. Consumption of sugar-sweetened drinks in excess is associated with an increased risk.JOURNAL, Malik VS, Popkin BM, Bray GA, Després JP, Hu FB, Sugar-sweetened beverages, obesity, type 2 diabetes mellitus, and cardiovascular disease risk, Circulation, 121, 11, 1356–64, March 2010, 20308626, 2862465, 10.1161/CIRCULATIONAHA.109.876185, JOURNAL, Malik VS, Popkin BM, Bray GA, Després JP, Willett WC, Hu FB, Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis, Diabetes Care, 33, 11, 2477–83, November 2010, 20693348, 2963518, 10.2337/dc10-1079, The type of fats in the diet is also important, with saturated fat and trans fats increasing the risk and polyunsaturated and monounsaturated fat decreasing the risk. Eating lots of white rice, and other starches, also may increase the risk of diabetes.JOURNAL, Hu EA, Pan A, Malik V, Sun Q, White rice consumption and risk of type 2 diabetes: meta-analysis and systematic review, BMJ, 344, e1454, March 2012, 22422870, 3307808, 10.1136/bmj.e1454, A lack of physical activity is believed to cause 7% of cases.JOURNAL, Lee IM, Shiroma EJ, Lobelo F, Puska P, Blair SN, Katzmarzyk PT, Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy, Lancet, 380, 9838, 219–29, July 2012, 22818936, 3645500, 10.1016/S0140-6736(12)61031-9,

Gestational diabetes

Gestational diabetes mellitus (GDM) resembles type 2 DM in several respects, involving a combination of relatively inadequate insulin secretion and responsiveness. It occurs in about 2–10% of all pregnancies and may improve or disappear after delivery.WEB, National Diabetes Clearinghouse (NDIC): National Diabetes Statistics 2011,weblink U.S. Department of Health and Human Services, 22 April 2014, no,weblink" title="">weblink 17 April 2014, However, after pregnancy approximately 5–10% of women with GDM are found to have DM, most commonly type 2. GDM is fully treatable, but requires careful medical supervision throughout the pregnancy. Management may include dietary changes, blood glucose monitoring, and in some cases, insulin may be requiredWEB,weblink Managing & Treating Gestational Diabetes {{!, NIDDK|website=National Institute of Diabetes and Digestive and Kidney Diseases|language=en-US|access-date=2019-05-06}}Though it may be transient, untreated GDM can damage the health of the fetus or mother. Risks to the baby include macrosomia (high birth weight), congenital heart and central nervous system abnormalities, and skeletal muscle malformations. Increased levels of insulin in a fetus's blood may inhibit fetal surfactant production and cause infant respiratory distress syndrome. A high blood bilirubin level may result from red blood cell destruction. In severe cases, perinatal death may occur, most commonly as a result of poor placental perfusion due to vascular impairment. Labor induction may be indicated with decreased placental function. A caesarean section may be performed if there is marked fetal distress or an increased risk of injury associated with macrosomia, such as shoulder dystocia.BOOK, National Collaborating Centre for Women's and Children's Health, February 2015, Intrapartum care,weblink Diabetes in Pregnancy: Management of diabetes and its complications from preconception to the postnatal period, National Institute for Health and Care Excellence (UK), en,

Other types

Maturity onset diabetes of the young (MODY) is a rare autosomal dominant inherited form of diabetes, due to one of several single-gene mutations causing defects in insulin production.WEB, Monogenic Forms of Diabetes,weblink National institute of diabetes and digestive and kidney diseases, US NIH, 12 March 2017, no,weblink 12 March 2017, It is significantly less common than the three main types, constituting 1-2% of all cases. The name of this disease refers to early hypotheses as to its nature. Being due to a defective gene, this disease varies in age at presentation and in severity according to the specific gene defect; thus there are at least 13 subtypes of MODY. People with MODY often can control it without using insulin.JOURNAL, Thanabalasingham G, Owen KR, Diagnosis and management of maturity onset diabetes of the young (MODY), BMJ, 343, oct19 3, d6044, October 2011, 22012810, 10.1136/bmj.d6044, Some cases of diabetes are caused by the body's tissue receptors not responding to insulin (even when insulin levels are normal, which is what separates it from type 2 diabetes); this form is very uncommon. Genetic mutations (autosomal or mitochondrial) can lead to defects in beta cell function. Abnormal insulin action may also have been genetically determined in some cases. Any disease that causes extensive damage to the pancreas may lead to diabetes (for example, chronic pancreatitis and cystic fibrosis). Diseases associated with excessive secretion of insulin-antagonistic hormones can cause diabetes (which is typically resolved once the hormone excess is removed). Many drugs impair insulin secretion and some toxins damage pancreatic beta cells, whereas others increase insulin resistance (especially glucocorticoids which can provoke "steroid diabetes"). The ICD-10 (1992) diagnostic entity, malnutrition-related diabetes mellitus (MRDM or MMDM, ICD-10 code E12), was deprecated by the World Health Organization (WHO) when the current taxonomy was introduced in 1999.WEB, World Health Organization, Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications, 1999,weblink no,weblink" title="">weblink 2003-03-08, The following is a comprehensive list of other causes of diabetes:Unless otherwise specified, reference is: Table 20-5 in BOOK, Mitchell, Richard Sheppard, Kumar, Vinay, Abbas, Abul K., Fausto, Nelson, Robbins Basic Pathology, Saunders, Philadelphia, 978-1-4160-2973-1, 8th, 2007, {{Col-begin}}{{Col-2}} {{Col-2}} {{Col-end}}Type 3 diabetes is a name used by some researchers for Alzheimer's disease, as there is evidence that insulin resistance in the brain plays a role in the latter. It is not formally recognised as a form of diabetes.JOURNAL, Bloom GS, Lazo JS, Norambuena A, Reduced brain insulin signaling: A seminal process in Alzheimer's disease pathogenesis, Neuropharmacology, 136, Pt B, 192–195, July 2018, 28965829, 5876069, 10.1016/j.neuropharm.2017.09.016,


File:Suckale08 fig3 glucose insulin day.png|thumb|upright=1.4|The fluctuation of blood sugar (red) and the sugar-lowering hormone insulin (blue) in humans during the course of a day with three meals. One of the effects of a sugar-rich vs a starchstarchFile:Glucose-insulin-release.svg|thumb|upright=1.4|Mechanism of insulin release in normal pancreatic beta cellbeta cellInsulin is the principal hormone that regulates the uptake of glucose from the blood into most cells of the body, especially liver, adipose tissue and muscle, except smooth muscle, in which insulin acts via the IGF-1. Therefore, deficiency of insulin or the insensitivity of its receptors play a central role in all forms of diabetes mellitus.WEB, Insulin Basics,weblink American Diabetes Association, 24 April 2014, no,weblink" title="">weblink 14 February 2014, The body obtains glucose from three main sources: the intestinal absorption of food; the breakdown of glycogen (glycogenolysis), the storage form of glucose found in the liver; and gluconeogenesis, the generation of glucose from non-carbohydrate substrates in the body.BOOK, Shoback DG, Gardner D, Greenspan's basic & clinical endocrinology, 2011, McGraw-Hill Medical, 978-0-07-162243-1, 9th, Insulin plays a critical role in balancing glucose levels in the body. Insulin can inhibit the breakdown of glycogen or the process of gluconeogenesis, it can stimulate the transport of glucose into fat and muscle cells, and it can stimulate the storage of glucose in the form of glycogen.Insulin is released into the blood by beta cells (β-cells), found in the islets of Langerhans in the pancreas, in response to rising levels of blood glucose, typically after eating. Insulin is used by about two-thirds of the body's cells to absorb glucose from the blood for use as fuel, for conversion to other needed molecules, or for storage. Lower glucose levels result in decreased insulin release from the beta cells and in the breakdown of glycogen to glucose. This process is mainly controlled by the hormone glucagon, which acts in the opposite manner to insulin.BOOK, Barrett KE, etal, Ganong's review of medical physiology, 2012, McGraw-Hill Medical, 978-0-07-178003-2, 24th, If the amount of insulin available is insufficient, or if cells respond poorly to the effects of insulin (insulin insensitivity or insulin resistance), or if the insulin itself is defective, then glucose is not absorbed properly by the body cells that require it, and is not stored appropriately in the liver and muscles. The net effect is persistently high levels of blood glucose, poor protein synthesis, and other metabolic derangements, such as acidosis.When glucose concentration in the blood remains high over time, the kidneys reach a threshold of reabsorption, and the body excretes glucose in the urine (glycosuria).BOOK, Murray RK, etal, Harper's illustrated biochemistry, 2012, McGraw-Hill Medical, 978-0-07-176576-3, 29th, This increases the osmotic pressure of the urine and inhibits reabsorption of water by the kidney, resulting in increased urine production (polyuria) and increased fluid loss. Lost blood volume is replaced osmotically from water in body cells and other body compartments, causing dehydration and increased thirst (polydipsia). In addition, intracellular glucose deficiency stimulates appetite leading to excessive food intake (polyphagia).BOOK, Juta's Complete Textbook of Medical Surgical Nursing, Mogotlane, Sophie, Juta, 2013, Cape Town, 839,


{{See also|Glycated hemoglobin|Glucose tolerance test}}{{OGTT}}Diabetes mellitus is characterized by recurrent or persistent high blood sugar, and is diagnosed by demonstrating any one of the following:
  • Fasting plasma glucose level ≥ 7.0 mmol/l (126 mg/dl)
  • Plasma glucose ≥ 11.1 mmol/l (200 mg/dl) two hours after a 75 gram oral glucose load as in a glucose tolerance test (OGTT)
  • Symptoms of high blood sugar and casual plasma glucose ≥ 11.1 mmol/l (200 mg/dl)
  • Glycated hemoglobin (HbA1C) ≥ 48 mmol/mol (≥ 6.5 DCCT %).JOURNAL, Diabetes Care, 33, S3,weblink "Diabetes Care" January 2010, 29 January 2010, no,weblink" title="">weblink 13 January 2010, 10.2337/dc10-S003, 20042773, 2797388, 2009,
A positive result, in the absence of unequivocal high blood sugar, should be confirmed by a repeat of any of the above methods on a different day. It is preferable to measure a fasting glucose level because of the ease of measurement and the considerable time commitment of formal glucose tolerance testing, which takes two hours to complete and offers no prognostic advantage over the fasting test.JOURNAL, Saydah SH, Miret M, Sung J, Varas C, Gause D, Brancati FL, Postchallenge hyperglycemia and mortality in a national sample of U.S. adults, Diabetes Care, 24, 8, 1397–402, August 2001, 11473076, 10.2337/diacare.24.8.1397, According to the current definition, two fasting glucose measurements above 7.0 mmol/l (126 mg/dl) is considered diagnostic for diabetes mellitus.Per the WHO, people with fasting glucose levels from 6.1 to 6.9 mmol/l (110 to 125 mg/dl) are considered to have impaired fasting glucose.BOOK, Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia : report of a WHO/IDF consultation,weblink World Health Organization, 21, 2006, 978-92-4-159493-6, no,weblink" title="">weblink 11 May 2012, people with plasma glucose at or above 7.8 mmol/l (140 mg/dl), but not over 11.1 mmol/l (200 mg/dl), two hours after a 75 gram oral glucose load are considered to have impaired glucose tolerance. Of these two prediabetic states, the latter in particular is a major risk factor for progression to full-blown diabetes mellitus, as well as cardiovascular disease.WEB, Santaguida PL, Balion C, Hunt D, Morrison K, Gerstein H, Raina P, Booker L, Yazdi H,weblink Diagnosis, Prognosis, and Treatment of Impaired Glucose Tolerance and Impaired Fasting Glucose, Summary of Evidence Report/Technology Assessment, No. 128, Agency for Healthcare Research and Quality, 20 July 2008, no,weblink" title="">weblink 16 September 2008, The American Diabetes Association (ADA) since 2003 uses a slightly different range for impaired fasting glucose of 5.6 to 6.9 mmol/l (100 to 125 mg/dl).JOURNAL, Bartoli E, Fra GP, Carnevale Schianca GP, The oral glucose tolerance test (OGTT) revisited, European Journal of Internal Medicine, 22, 1, 8–12, February 2011, 21238885, 10.1016/j.ejim.2010.07.008, Glycated hemoglobin is better than fasting glucose for determining risks of cardiovascular disease and death from any cause.JOURNAL, Selvin E, Steffes MW, Zhu H, Matsushita K, Wagenknecht L, Pankow J, Coresh J, Brancati FL, Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults, The New England Journal of Medicine, 362, 9, 800–11, March 2010, 20200384, 2872990, 10.1056/NEJMoa0908359,,


{{See also|Prevention of diabetes mellitus type 2}}There is no known preventive measure for type 1 diabetes. Type 2 diabetes—which accounts for 85–90% of all cases worldwide—can often be prevented or delayed by maintaining a normal body weight, engaging in physical activity, and eating a healthy diet. Higher levels of physical activity (more than 90 minutes per day) reduce the risk of diabetes by 28%.JOURNAL, Kyu HH, Bachman VF, Alexander LT, Mumford JE, Afshin A, Estep K, Veerman JL, Delwiche K, Iannarone ML, Moyer ML, Cercy K, Vos T, Murray CJ, Forouzanfar MH, Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events: systematic review and dose-response meta-analysis for the Global Burden of Disease Study 2013, BMJ, 354, i3857, August 2016, 27510511, 4979358, 10.1136/bmj.i3857, Dietary changes known to be effective in helping to prevent diabetes include maintaining a diet rich in whole grains and fiber, and choosing good fats, such as the polyunsaturated fats found in nuts, vegetable oils, and fish.WEB, The Nutrition Source,weblink Harvard School of Public Health, 24 April 2014, no,weblink" title="">weblink 25 April 2014, 2012-09-18, Limiting sugary beverages and eating less red meat and other sources of saturated fat can also help prevent diabetes. Tobacco smoking is also associated with an increased risk of diabetes and its complications, so smoking cessation can be an important preventive measure as well.JOURNAL, Willi C, Bodenmann P, Ghali WA, Faris PD, Cornuz J, Active smoking and the risk of type 2 diabetes: a systematic review and meta-analysis, JAMA, 298, 22, 2654–64, December 2007, 18073361, 10.1001/jama.298.22.2654, The relationship between type 2 diabetes and the main modifiable risk factors (excess weight, unhealthy diet, physical inactivity and tobacco use) is similar in all regions of the world. There is growing evidence that the underlying determinants of diabetes are a reflection of the major forces driving social, economic and cultural change: globalization, urbanization, population aging, and the general health policy environment.WEB, World Health Organization,weblink Chronic diseases and their common risk factors, no,weblink" title="">weblink 2016-10-17, 2005, 30 August 2016,


(File:ABCs of Diabetes.webm|thumb|Overview of the management of diabetes)Diabetes mellitus is a chronic disease, for which there is no known cure except in very specific situations.WEB,weblink No cure for diabetes, no,weblink" title="">weblink 2015-05-21, 21 May 2015, WebMD, Management concentrates on keeping blood sugar levels as close to normal, without causing low blood sugar. This can usually be accomplished with a healthy diet, exercise, weight loss, and use of appropriate medications (insulin in the case of type 1 diabetes; oral medications, as well as possibly insulin, in type 2 diabetes).Learning about the disease and actively participating in the treatment is important, since complications are far less common and less severe in people who have well-managed blood sugar levels.JOURNAL, Nathan DM, Cleary PA, Backlund JY, Genuth SM, Lachin JM, Orchard TJ, Raskin P, Zinman B, Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes, The New England Journal of Medicine, 353, 25, 2643–53, December 2005, 16371630, 2637991, 10.1056/NEJMoa052187, JOURNAL, The effect of intensive diabetes therapy on the development and progression of neuropathy. The Diabetes Control and Complications Trial Research Group, Annals of Internal Medicine, 122, 8, 561–68, April 1995, 7887548, 10.7326/0003-4819-122-8-199504150-00001, The goal of treatment is an HbA1C level of 6.5%, but should not be lower than that, and may be set higher. Attention is also paid to other health problems that may accelerate the negative effects of diabetes. These include smoking, elevated cholesterol levels, obesity, high blood pressure, and lack of regular exercise.{{NICE|66|Type 2 diabetes|2008}} Specialized footwear is widely used to reduce the risk of ulceration, or re-ulceration, in at-risk diabetic feet. Evidence for the efficacy of this remains equivocal, however.JOURNAL, Cavanagh PR, Therapeutic footwear for people with diabetes, Diabetes/Metabolism Research and Reviews, 20 Suppl 1, Suppl 1, S51–55, 2004, 15150815, 10.1002/dmrr.435,


{{See also|Diabetic diet}}People with diabetes can benefit from education about the disease and treatment, good nutrition to achieve a normal body weight, and exercise, with the goal of keeping both short-term and long-term blood glucose levels within acceptable bounds. In addition, given the associated higher risks of cardiovascular disease, lifestyle modifications are recommended to control blood pressure.JOURNAL, Haw JS, Galaviz KI, Straus AN, Kowalski AJ, Magee MJ, Weber MB, Wei J, Narayan KM, Ali MK, Long-term Sustainability of Diabetes Prevention Approaches: A Systematic Review and Meta-analysis of Randomized Clinical Trials, JAMA Internal Medicine, 177, 12, 1808–17, December 2017, 29114778, 5820728, 10.1001/jamainternmed.2017.6040, JOURNAL, Mottalib A, Kasetty M, Mar JY, Elseaidy T, Ashrafzadeh S, Hamdy O, Weight Management in Patients with Type 1 Diabetes and Obesity, Current Diabetes Reports, 17, 10, 92, August 2017, 28836234, 5569154, 10.1007/s11892-017-0918-8, No single dietary pattern is best for all people with diabetes. For overweight people with type 2 diabetes, any diet that achieves weight loss is effective.JOURNAL, Emadian A, Andrews RC, England CY, Wallace V, Thompson JL, The effect of macronutrients on glycaemic control: a systematic review of dietary randomised controlled trials in overweight and obese adults with type 2 diabetes in which there was no difference in weight loss between treatment groups, The British Journal of Nutrition, 114, 10, 1656–66, November 2015, 26411958, 4657029, 10.1017/S0007114515003475, JOURNAL, Grams J, Garvey WT, Weight Loss and the Prevention and Treatment of Type 2 Diabetes Using Lifestyle Therapy, Pharmacotherapy, and Bariatric Surgery: Mechanisms of Action, Current Obesity Reports, 4, 2, 287–302, June 2015, 26627223, 10.1007/s13679-015-0155-x,


Glucose control

{{see also|Anti-diabetic medication}}Medications used to treat diabetes do so by lowering blood sugar levels. There is broad consensus that when people with diabetes maintain tight glucose control (also called "tight glycemic control") – keeping the glucose levels in their blood within normal ranges – that they experience fewer complications like kidney problems and eye problems.JOURNAL, Rosberger DF, Diabetic retinopathy: current concepts and emerging therapy, Endocrinology and Metabolism Clinics of North America, 42, 4, 721–45, December 2013, 24286948, 10.1016/j.ecl.2013.08.001, JOURNAL, MacIsaac RJ, Jerums G, Ekinci EI, Glycemic Control as Primary Prevention for Diabetic Kidney Disease, Advances in Chronic Kidney Disease, 25, 2, 141–148, March 2018, 29580578, 10.1053/j.ackd.2017.11.003, There is however debate as to whether this is cost effective for people later in life.JOURNAL, Pozzilli P, Strollo R, Bonora E, One size does not fit all glycemic targets for type 2 diabetes, Journal of Diabetes Investigation, 5, 2, 134–41, March 2014, 24843750, 4023573, 10.1111/jdi.12206, There are a number of different classes of anti-diabetic medications. Some are available by mouth, such as metformin, while others are only available by injection such as GLP-1 agonists. Type 1 diabetes can only be treated with insulin, typically with a combination of regular and NPH insulin, or synthetic insulin analogs.{{citation needed|date=April 2015}}Metformin is generally recommended as a first line treatment for type 2 diabetes, as there is good evidence that it decreases mortality.JOURNAL, Ripsin CM, Kang H, Urban RJ, Management of blood glucose in type 2 diabetes mellitus, American Family Physician, 79, 1, 29–36, January 2009, 19145963,weblinkweblink" title="">weblink no, 2013-05-05, It works by decreasing the liver's production of glucose.JOURNAL, Krentz AJ, Bailey CJ, Oral antidiabetic agents: current role in type 2 diabetes mellitus, Drugs, 65, 3, 385–411, 2005, 15669880, 10.2165/00003495-200565030-00005, Several other groups of drugs, mostly given by mouth, may also decrease blood sugar in type II DM. These include agents that increase insulin release, agents that decrease absorption of sugar from the intestines, and agents that make the body more sensitive to insulin. When insulin is used in type 2 diabetes, a long-acting formulation is usually added initially, while continuing oral medications. Doses of insulin are then increased to effect.{{Citation| author1 = Consumer Reports| author2-link = American College of Physicians| author2 = American College of Physicians| date = April 2012| title = Choosing a type 2 diabetes drug – Why the best first choice is often the oldest drug| publisher = Consumer Reports| work = High Value Care| page = | url =weblink| access-date = August 14, 2012| deadurl = no| archive-url =weblink" title="">weblink| archive-date = July 2, 2014| df = | author1-link = Consumer Reports}}

Blood pressure

Since cardiovascular disease is a serious complication associated with diabetes, some have recommended blood pressure levels below 130/80 mmHg.JOURNAL,weblink Drug treatment of elevated blood pressure, Nelson, Mark, Australian Prescriber, 33, 108–12, 11 August 2010, yes,weblink" title="">weblink 26 August 2010, However, evidence supports less than or equal to somewhere between 140/90 mmHg to 160/100 mmHg; the only additional benefit found for blood pressure targets beneath this range was an isolated decrease in stroke risk, and this was accompanied by an increased risk of other serious adverse events.JOURNAL, Arguedas JA, Perez MI, Wright JM, Treatment blood pressure targets for hypertension, The Cochrane Database of Systematic Reviews, 3, CD004349, July 2009, 19588353, 10.1002/14651858.CD004349.pub2, Arguedas, Jose Agustin, JOURNAL, Arguedas JA, Leiva V, Wright JM, Blood pressure targets for hypertension in people with diabetes mellitus, The Cochrane Database of Systematic Reviews, 10, 10, CD008277, October 2013, 24170669, 10.1002/14651858.cd008277.pub2, A 2016 review found potential harm to treating lower than 140 mmHg.JOURNAL, Brunström M, Carlberg B, Effect of antihypertensive treatment at different blood pressure levels in patients with diabetes mellitus: systematic review and meta-analyses, BMJ, 352, i717, February 2016, 26920333, 4770818, 10.1136/bmj.i717, Among medications that lower blood pressure, angiotensin converting enzyme inhibitors (ACEIs) improve outcomes in those with DM while the similar medications angiotensin receptor blockers (ARBs) do not.JOURNAL, Cheng J, Zhang W, Zhang X, Han F, Li X, He X, Li Q, Chen J, Effect of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on all-cause mortality, cardiovascular deaths, and cardiovascular events in patients with diabetes mellitus: a meta-analysis, JAMA Internal Medicine, 174, 5, 773–85, May 2014, 24687000, 10.1001/jamainternmed.2014.348, Aspirin is also recommended for people with cardiovascular problems, however routine use of aspirin has not been found to improve outcomes in uncomplicated diabetes.JOURNAL, Pignone M, Alberts MJ, Colwell JA, Cushman M, Inzucchi SE, Mukherjee D, Rosenson RS, Williams CD, Wilson PW, Kirkman MS, Aspirin for primary prevention of cardiovascular events in people with diabetes: a position statement of the American Diabetes Association, a scientific statement of the American Heart Association, and an expert consensus document of the American College of Cardiology Foundation, Diabetes Care, 33, 6, 1395–402, June 2010, 20508233, 2875463, 10.2337/dc10-0555,


Weight loss surgery in those with obesity and type two diabetes is often an effective measure. Many are able to maintain normal blood sugar levels with little or no medications following surgeryJOURNAL, Frachetti KJ, Goldfine AB, Bariatric surgery for diabetes management, Current Opinion in Endocrinology, Diabetes and Obesity, 16, 2, 119–24, April 2009, 19276974, 10.1097/MED.0b013e32832912e7, and long-term mortality is decreased. There is, however, a short-term mortality risk of less than 1% from the surgery.JOURNAL, Colucci RA, Bariatric surgery in patients with type 2 diabetes: a viable option, Postgraduate Medicine, 123, 1, 24–33, January 2011, 21293081, 10.3810/pgm.2011.01.2242, The body mass index cutoffs for when surgery is appropriate are not yet clear.JOURNAL, Schulman AP, del Genio F, Sinha N, Rubino F, "Metabolic" surgery for treatment of type 2 diabetes mellitus, Endocrine Practice, 15, 6, 624–31, September–October 2009, 19625245, 10.4158/EP09170.RAR, It is recommended that this option be considered in those who are unable to get both their weight and blood sugar under control.JOURNAL, Dixon JB, le Roux CW, Rubino F, Zimmet P, Bariatric surgery for type 2 diabetes, Lancet, 379, 9833, 2300–11, June 2012, 22683132, 10.1016/S0140-6736(12)60401-2, A pancreas transplant is occasionally considered for people with type 1 diabetes who have severe complications of their disease, including end stage kidney disease requiring kidney transplantation.WEB, Pancreas Transplantation,weblink American Diabetes Association, 9 April 2014, no,weblink" title="">weblink 13 April 2014,


In countries using a general practitioner system, such as the United Kingdom, care may take place mainly outside hospitals, with hospital-based specialist care used only in case of complications, difficult blood sugar control, or research projects. In other circumstances, general practitioners and specialists share care in a team approach. Home telehealth support can be an effective management technique.JOURNAL, Polisena J, Tran K, Cimon K, Hutton B, McGill S, Palmer K, Home telehealth for diabetes management: a systematic review and meta-analysis, Diabetes, Obesity & Metabolism, 11, 10, 913–30, October 2009, 19531058, 10.1111/j.1463-1326.2009.01057.x,


(File:Prevalence of Diabetes by Percent of Country Population (2014) Gradient Map.png|thumb|upright=1.4|Rates of diabetes worldwide in 2014. The worldwide prevalence was 9.2%.)(File:Diabetes mellitus world map-Deaths per million persons-WHO2012.svg|thumb|upright=1.4|Mortality rate of diabetes worldwide in 2012 per million inhabitants {{legend|#ffff20|28–91}}{{legend|#ffe820|92–114}}{{legend|#ffd820|115–141}}{{legend|#ffc020|142–163}}{{legend|#ffa020|164–184}}{{legend|#ff9a20|185–209}}{{legend|#f08015|210–247}}{{legend|#e06815|248–309}}{{legend|#d85010|310–404}}{{legend|#d02010|405–1879}})In 2017, 425 million people had diabetes worldwide, up from an estimated 382 million people in 2013 and from 108 million in 1980.WEB, Global Report on Diabetes, World Health Organization,weblink 20 September 2018, 2016, Accounting for the shifting age structure of the global population, the prevalence of diabetes is 8.8% among adults, nearly double the rate of 4.7% in 1980. Type 2 makes up about 90% of the cases.JOURNAL, Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, Abraham J, Ackerman I, Aggarwal R, Ahn SY, Ali MK, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Bahalim AN, Barker-Collo S, Barrero LH, Bartels DH, Basáñez MG, Baxter A, Bell ML, Benjamin EJ, Bennett D, Bernabé E, Bhalla K, Bhandari B, Bikbov B, Bin Abdulhak A, Birbeck G, Black JA, Blencowe H, Blore JD, Blyth F, Bolliger I, Bonaventure A, Boufous S, Bourne R, Boussinesq M, Braithwaite T, Brayne C, Bridgett L, Brooker S, Brooks P, Brugha TS, Bryan-Hancock C, Bucello C, Buchbinder R, Buckle G, Budke CM, Burch M, Burney P, Burstein R, Calabria B, Campbell B, Canter CE, Carabin H, Carapetis J, Carmona L, Cella C, Charlson F, Chen H, Cheng AT, Chou D, Chugh SS, Coffeng LE, Colan SD, Colquhoun S, Colson KE, Condon J, Connor MD, Cooper LT, Corriere M, Cortinovis M, de Vaccaro KC, Couser W, Cowie BC, Criqui MH, Cross M, Dabhadkar KC, Dahiya M, Dahodwala N, Damsere-Derry J, Danaei G, Davis A, De Leo D, Degenhardt L, Dellavalle R, Delossantos A, Denenberg J, Derrett S, Des Jarlais DC, Dharmaratne SD, Dherani M, Diaz-Torne C, Dolk H, Dorsey ER, Driscoll T, Duber H, Ebel B, Edmond K, Elbaz A, Ali SE, Erskine H, Erwin PJ, Espindola P, Ewoigbokhan SE, Farzadfar F, Feigin V, Felson DT, Ferrari A, Ferri CP, Fèvre EM, Finucane MM, Flaxman S, Flood L, Foreman K, Forouzanfar MH, Fowkes FG, Franklin R, Fransen M, Freeman MK, Gabbe BJ, Gabriel SE, Gakidou E, Ganatra HA, Garcia B, Gaspari F, Gillum RF, Gmel G, Gosselin R, Grainger R, Groeger J, Guillemin F, Gunnell D, Gupta R, Haagsma J, Hagan H, Halasa YA, Hall W, Haring D, Haro JM, Harrison JE, Havmoeller R, Hay RJ, Higashi H, Hill C, Hoen B, Hoffman H, Hotez PJ, Hoy D, Huang JJ, Ibeanusi SE, Jacobsen KH, James SL, Jarvis D, Jasrasaria R, Jayaraman S, Johns N, Jonas JB, Karthikeyan G, Kassebaum N, Kawakami N, Keren A, Khoo JP, King CH, Knowlton LM, Kobusingye O, Koranteng A, Krishnamurthi R, Lalloo R, Laslett LL, Lathlean T, Leasher JL, Lee YY, Leigh J, Lim SS, Limb E, Lin JK, Lipnick M, Lipshultz SE, Liu W, Loane M, Ohno SL, Lyons R, Ma J, Mabweijano J, MacIntyre MF, Malekzadeh R, Mallinger L, Manivannan S, Marcenes W, March L, Margolis DJ, Marks GB, Marks R, Matsumori A, Matzopoulos R, Mayosi BM, McAnulty JH, McDermott MM, McGill N, McGrath J, Medina-Mora ME, Meltzer M, Mensah GA, Merriman TR, Meyer AC, Miglioli V, Miller M, Miller TR, Mitchell PB, Mocumbi AO, Moffitt TE, Mokdad AA, Monasta L, Montico M, Moradi-Lakeh M, Moran A, Morawska L, Mori R, Murdoch ME, Mwaniki MK, Naidoo K, Nair MN, Naldi L, Narayan KM, Nelson PK, Nelson RG, Nevitt MC, Newton CR, Nolte S, Norman P, Norman R, O'Donnell M, O'Hanlon S, Olives C, Omer SB, Ortblad K, Osborne R, Ozgediz D, Page A, Pahari B, Pandian JD, Rivero AP, Patten SB, Pearce N, Padilla RP, Perez-Ruiz F, Perico N, Pesudovs K, Phillips D, Phillips MR, Pierce K, Pion S, Polanczyk GV, Polinder S, Pope CA, Popova S, Porrini E, Pourmalek F, Prince M, Pullan RL, Ramaiah KD, Ranganathan D, Razavi H, Regan M, Rehm JT, Rein DB, Remuzzi G, Richardson K, Rivara FP, Roberts T, Robinson C, De Leòn FR, Ronfani L, Room R, Rosenfeld LC, Rushton L, Sacco RL, Saha S, Sampson U, Sanchez-Riera L, Sanman E, Schwebel DC, Scott JG, Segui-Gomez M, Shahraz S, Shepard DS, Shin H, Shivakoti R, Singh D, Singh GM, Singh JA, Singleton J, Sleet DA, Sliwa K, Smith E, Smith JL, Stapelberg NJ, Steer A, Steiner T, Stolk WA, Stovner LJ, Sudfeld C, Syed S, Tamburlini G, Tavakkoli M, Taylor HR, Taylor JA, Taylor WJ, Thomas B, Thomson WM, Thurston GD, Tleyjeh IM, Tonelli M, Towbin JA, Truelsen T, Tsilimbaris MK, Ubeda C, Undurraga EA, van der Werf MJ, van Os J, Vavilala MS, Venketasubramanian N, Wang M, Wang W, Watt K, Weatherall DJ, Weinstock MA, Weintraub R, Weisskopf MG, Weissman MM, White RA, Whiteford H, Wiersma ST, Wilkinson JD, Williams HC, Williams SR, Witt E, Wolfe F, Woolf AD, Wulf S, Yeh PH, Zaidi AK, Zheng ZJ, Zonies D, Lopez AD, Murray CJ, AlMazroa MA, Memish ZA, Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010, Lancet, 380, 9859, 2163–96, December 2012, 23245607, 6350784, 10.1016/S0140-6736(12)61729-2, 6, Some data indicate rates are roughly equal in women and men, but male excess in diabetes has been found in many populations with higher type 2 incidence, possibly due to sex-related differences in insulin sensitivity, consequences of obesity and regional body fat deposition, and other contributing factors such as high blood pressure, tobacco smoking, and alcohol intake.JOURNAL, Gale EA, Gillespie KM, Diabetes and gender, Diabetologia, 44, 1, 3–15, January 2001, 11206408, 10.1007/s001250051573, JOURNAL, Meisinger C, Thorand B, Schneider A, et al, 2002, Sex differences in risk factors for incident type 2 Diabetes Mellitus: The MONICA Augsburg Cohort Study, JAMA Internal Medicine, 162, 1, 82–89, 10.1001/archinte.162.1.82, The WHO estimates that diabetes mellitus resulted in 1.5 million deaths in 2012, making it the 8th leading cause of death. However another 2.2 million deaths worldwide were attributable to high blood glucose and the increased risks of cardiovascular disease and other associated complications (e.g. kidney failure), which often lead to premature death and are often listed as the underlying cause on death certificates rather than diabetes.Public Health Agency of Canada, Diabetes in Canada: Facts and figures from a public health perspective. Ottawa, 2011. For example, in 2017, the International Diabetes Federation (IDF) estimated that diabetes resulted in 4.0 million deaths worldwide, using modeling to estimate the total number of deaths that could be directly or indirectly attributed to diabetes.Diabetes mellitus occurs throughout the world but is more common (especially type 2) in more developed countries. The greatest increase in rates has however been seen in low- and middle-income countries, where more than 80% of diabetic deaths occur.JOURNAL, Mathers CD, Loncar D, Projections of global mortality and burden of disease from 2002 to 2030, PLoS Medicine, 3, 11, e442, November 2006, 17132052, 1664601, 10.1371/journal.pmed.0030442, The fastest prevalence increase is expected to occur in Asia and Africa, where most people with diabetes will probably live in 2030. The increase in rates in developing countries follows the trend of urbanization and lifestyle changes, including increasingly sedentary lifestyles, less physically demanding work and the global nutrition transition, marked by increased intake of foods that are high energy-dense but nutrient-poor (often high in sugar and saturated fats, sometimes referred to as the "Western-style" diet).JOURNAL, Wild S, Roglic G, Green A, Sicree R, King H, Global prevalence of diabetes: estimates for the year 2000 and projections for 2030, Diabetes Care, 27, 5, 1047–53, May 2004, 15111519, 10.2337/diacare.27.5.1047, The global number of diabetes cases might increase by 48% between 2017 and 2045.


Diabetes was one of the first diseases described,BOOK, Ripoll, Brian C. Leutholtz, Ignacio, Exercise and disease management, CRC Press, Boca Raton, 978-1-4398-2759-8, 25,weblink 2nd, 2011-04-25, no,weblink 2016-04-03, with an Egyptian manuscript from {{Abbr|c.|circa}} 1500 BCE mentioning "too great emptying of the urine." The Ebers papyrus includes a recommendation for a drink to take in such cases.MAGAZINE, Roberts, Jacob, Sickening sweet, Distillations, 2015, 1, 4, 12–15,weblink 20 March 2018, The first described cases are believed to have been type 1 diabetes.BOOK, Leonid, Poretsky, Principles of diabetes mellitus, 2009, Springer, New York, 978-0-387-09840-1, 3,weblink 2nd, no,weblink 2016-04-04, Indian physicians around the same time identified the disease and classified it as madhumeha or "honey urine", noting the urine would attract ants.The term "diabetes" or "to pass through" was first used in 230 BCE by the Greek Apollonius of Memphis. The disease was considered rare during the time of the Roman empire, with Galen commenting he had only seen two cases during his career. This is possibly due to the diet and lifestyle of the ancients, or because the clinical symptoms were observed during the advanced stage of the disease. Galen named the disease "diarrhea of the urine" (diarrhea urinosa).The earliest surviving work with a detailed reference to diabetes is that of Aretaeus of Cappadocia (2nd or early 3rd{{nbsp}}century CE). He described the symptoms and the course of the disease, which he attributed to the moisture and coldness, reflecting the beliefs of the "Pneumatic School". He hypothesized a correlation between diabetes and other diseases, and he discussed differential diagnosis from the snakebite, which also provokes excessive thirst. His work remained unknown in the West until 1552, when the first Latin edition was published in Venice.JOURNAL, Laios K, Karamanou M, Saridaki Z, Androutsos G, Aretaeus of Cappadocia and the first description of diabetes, Hormones, 11, 1, 109–13, 2012, 22450352,weblinkweblink" title="">weblink no, 2017-01-04, 10.1007/BF03401545, Two types of diabetes were identified as separate conditions for the first time by the Indian physicians Sushruta and Charaka in 400–500 CE with one type being associated with youth and another type with being overweight. The term "mellitus" or "from honey" was added by the Briton John Rolle in the late 1700s to separate the condition from diabetes insipidus, which is also associated with frequent urination. Effective treatment was not developed until the early part of the 20th century, when Canadians Frederick Banting and Charles Herbert Best isolated and purified insulin in 1921 and 1922. This was followed by the development of the long-acting insulin NPH in the 1940s.


The word diabetes ({{IPAc-en|ˌ|d|aɪ|.|ə|ˈ|b|iː|t|iː|z}} or {{IPAc-en|ˌ|d|aɪ|.|ə|ˈ|b|iː|t|ᵻ|s}}) comes from Latin diabētēs, which in turn comes from Ancient Greek διαβήτης (diabētēs), which literally means "a passer through; a siphon".Oxford English Dictionary. diabetes. Retrieved 2011-06-10. Ancient Greek physician Aretaeus of Cappadocia (fl. 1st{{nbsp}}century CE) used that word, with the intended meaning "excessive discharge of urine", as the name for the disease.WEB, Harper, Douglas, Online Etymology Dictionary. diabetes., 2001–2010,weblink 2011-06-10, no,weblink" title="">weblink 2012-01-13, Aretaeus, De causis et signis acutorum morborum (lib. 2), Κεφ. β. περὶ Διαβήτεω (Chapter 2, On Diabetes, Greek original) {{webarchive|url= |date=2014-07-02 }}, on Perseus Ultimately, the word comes from Greek διαβαίνειν (diabainein), meaning "to pass through," which is composed of δια- (dia-), meaning "through" and βαίνειν (bainein), meaning "to go". The word "diabetes" is first recorded in English, in the form diabete, in a medical text written around 1425.The word (wikt:mellitus|mellitus) ({{IPAc-en|m|ə|ˈ|l|aɪ|t|ə|s}} or {{IPAc-en|ˈ|m|ɛ|l|ᵻ|t|ə|s}}) comes from the classical Latin word mellītus, meaning "mellite"Oxford English Dictionary. mellite. Retrieved 2011-06-10. (i.e. sweetened with honey; honey-sweetWEB, MyEtimology. mellitus.,weblink 2011-06-10, no,weblink" title="">weblink 2011-03-16, ). The Latin word comes from mell-, which comes from mel, meaning "honey"; sweetness; pleasant thing, and the suffix -ītus, whose meaning is the same as that of the English suffix "-ite".Oxford English Dictionary. -ite. Retrieved 2011-06-10. It was Thomas Willis who in 1675 added "mellitus" to the word "diabetes" as a designation for the disease, when he noticed the urine of a diabetic had a sweet taste (glycosuria). This sweet taste had been noticed in urine by the ancient Greeks, Chinese, Egyptians, Indians, and Persians.

Society and culture

{{Further|List of films featuring diabetes}}The 1989 "St. Vincent Declaration"BOOK, Theodore H. Tulchinsky, Elena A. Varavikova, The New Public Health, Second Edition, Academic Press, 2008, 200, New York, 978-0-12-370890-8, JOURNAL, Piwernetz K, Home PD, Snorgaard O, Antsiferov M, Staehr-Johansen K, Krans M, Monitoring the targets of the St Vincent Declaration and the implementation of quality management in diabetes care: the DIABCARE initiative. The DIABCARE Monitoring Group of the St Vincent Declaration Steering Committee, Diabetic Medicine, 10, 4, 371–77, May 1993, 8508624, 10.1111/j.1464-5491.1993.tb00083.x, was the result of international efforts to improve the care accorded to those with diabetes. Doing so is important not only in terms of quality of life and life expectancy but also economically{{snd}}expenses due to diabetes have been shown to be a major drain on health{{snd}}and productivity-related resources for healthcare systems and governments.Several countries established more and less successful national diabetes programmes to improve treatment of the disease.JOURNAL, Dubois H, Bankauskaite V, Type 2 diabetes programmes in Europe, Euro Observer, 7, 2, 5–6, 2005,weblink no,weblink" title="">weblink 2012-10-24, People with diabetes who have neuropathic symptoms such as numbness or tingling in feet or hands are twice as likely to be unemployed as those without the symptoms.JOURNAL, Stewart WF, Ricci JA, Chee E, Hirsch AG, Brandenburg NA, Lost productive time and costs due to diabetes and diabetic neuropathic pain in the US workforce, Journal of Occupational and Environmental Medicine, 49, 6, 672–79, June 2007, 17563611, 10.1097/JOM.0b013e318065b83a, In 2010, diabetes-related emergency room (ER) visit rates in the United States were higher among people from the lowest income communities (526 per 10,000 population) than from the highest income communities (236 per 10,000 population). Approximately 9.4% of diabetes-related ER visits were for the uninsured.WEB, Washington R.E., Andrews R.M., Mutter R.L., Emergency Department Visits for Adults with Diabetes, 2010, November 2013, HCUP Statistical Brief #167, Agency for Healthcare Research and Quality,weblink Rockville MD, no,weblink" title="">weblink 2013-12-03,


The term "type 1 diabetes" has replaced several former terms, including childhood-onset diabetes, juvenile diabetes, and insulin-dependent diabetes mellitus (IDDM). Likewise, the term "type 2 diabetes" has replaced several former terms, including adult-onset diabetes, obesity-related diabetes, and noninsulin-dependent diabetes mellitus (NIDDM). Beyond these two types, there is no agreed-upon standard nomenclature.{{citation needed|date=January 2017}}Diabetes mellitus is also occasionally known as "sugar diabetes" to differentiate it from diabetes insipidus.BOOK, Parker, Katrina, Living with diabetes, 2008, Facts On File, New York, 978-1-4381-2108-6, 143,weblink no,weblink 2017-09-06,

Other animals

In animals, diabetes is most commonly encountered in dogs and cats. Middle-aged animals are most commonly affected. Female dogs are twice as likely to be affected as males, while according to some sources, male cats are also more prone than females. In both species, all breeds may be affected, but some small dog breeds are particularly likely to develop diabetes, such as Miniature Poodles.WEB, Diabetes mellitus, Merck Veterinary Manual, 9th edition (online version),weblink 2005, 2011-10-23, no,weblink" title="">weblink 2011-09-27, Feline diabetes mellitus is strikingly similar to human type 2 diabetes. The Burmese breed, along with the Russian Blue, Abyssinian, and Norwegian Forest cat breeds, showed an increased risk of DM, while several breeds showed a lower risk. There is an association between overweight and an increased risk of feline diabetes.BOOK, Öhlund, Malin, Feline diabetes mellitus Aspects on epidemiology and pathogenesis, Acta Universitatis agriculturae Sueciae, 978-91-7760-067-1,weblink The symptoms may relate to fluid loss and polyuria, but the course may also be insidious. Diabetic animals are more prone to infections. The long-term complications recognized in humans are much rarer in animals. The principles of treatment (weight loss, oral antidiabetics, subcutaneous insulin) and management of emergencies (e.g. ketoacidosis) are similar to those in humans.


{{also|Diabetes (journal)}}Inhalable insulin has been developed.JOURNAL, Maria Rotella C, Pala L, Mannucci E, Role of insulin in the type 2 diabetes therapy: past, present and future, International Journal of Endocrinology and Metabolism, 11, 3, 137–44, Summer 2013, 24348585, 3860110, 10.5812/ijem.7551, The original products were withdrawn due to side effects. Afrezza, under development by the pharmaceuticals company MannKind Corporation, was approved by the United States Food and Drug Administration (FDA) for general sale in June 2014.JOURNAL,weblink Press Announcement, Journal of Polymer Science B Polymer Physics, 8, 10, 1845, 11 February 2016, no,weblink" title="">weblink 3 March 2016, 1970JPoSB...8.1845., 1970, 10.1002/pol.1970.160081020, An advantage to inhaled insulin is that it may be more convenient and easy to use.NEWS, Inhaled Insulin Clears Hurdle Toward F.D.A. Approval,weblink 12 April 2014, New York Times, no,weblink" title="">weblink 7 April 2014, Transdermal insulin in the form of a cream has been developed and trials are being conducted on people with type{{nbsp}}2 diabetes.WEB,weblink World's first transdermal insulin shows promise,, 2016-07-03, no,weblink" title="">weblink 2015-05-01, WEB,weblink Phosphagenics Initiates Trial of Transdermal Insulin Gel,, 2016-07-03, no,weblink" title="">weblink 2016-08-18,

Major clinical trials

The Diabetes Control and Complications Trial (DCCT) was a clinical study conducted by the United States National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) that was published in the New England Journal of Medicine in 1993. Test subjects all had diabetes mellitus type 1 and were randomized to a tight glycemic arm and a control arm with the standard of care at the time; people were followed for an average of seven years, and people in the treatment had dramatically lower rates of diabetic complications. It was as a landmark study at the time, and significantly changed the management of all forms of diabetes.JOURNAL, American Diabetes Association Statement: Implications of the Diabetes Control and Complications Trial, Diabetes Care, 1 January 2003, 26, Supplement 1, S25–S27, 10.2337/diacare.26.2007.S25, JOURNAL, The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitusauthor2=Complications Trial Research Group., N Engl J Meddoi=10.1056/NEJM199309303291401volume=329issue=14, The United Kingdom Prospective Diabetes Study (UKPDS) was a clinical study conducted by Z that was published in The Lancet in 1998. Around 3,800 people with type 2 diabetes were followed for an average of ten years, and were treated with tight glucose control or the standard of care, and again the treatment arm had far better outcomes. This confirmed the importance of tight glucose control, as well as blood pressure control, for people with this condition.WEB, Position statement: UKPDS – Implications for the care of people with Type 2 diabetes,weblink Diabetes UK,weblink" title="">weblink 2 March 2009, January 1999, JOURNAL, 10.1016/S0140-6736(98)07019-6, 9742976, Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33), The Lancet, 352, 9131, 837–53, 1998,



External links

{{Medical condition classification and resourcesE10}}–{{ICD1014e|10}}250}}| MedlinePlus=001214| eMedicineSubj=med| eMedicineTopic=546emerg|134}}}}{{Sister project links|display=Diabetes mellitus}} {{diabetes}}{{Authority control}}

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