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cell (biology)
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{{About|the term in biology|other uses|Cell (disambiguation){{!}}Cell}}{{Pp|small=yes}}{{pp-move-indef}}







factoids
(File:Structure of animal cell.JPG|thumbnail|Structure of an animal cell)The cell (from Latin cella, meaning "small room"WEB, Cell,weblink Online Etymology Dictionary, 31 December 2012, ) is the basic structural, functional, and biological unit of all known living organisms. A cell is the smallest unit of life. Cells are often called the "building blocks of life". The study of cells is called cell biology.Cells consist of cytoplasm enclosed within a membrane, which contains many biomolecules such as proteins and nucleic acids.Cell Movements and the Shaping of the Vertebrate Body in Chapter 21 of Molecular Biology of the Cell fourth edition, edited by Bruce Alberts (2002) published by Garland Science. The Alberts text discusses how the "cellular building blocks" move to shape developing embryos. It is also common to describe small molecules such as amino acids as "molecular building blocks". Organisms can be classified as unicellular (consisting of a single cell; including bacteria) or multicellular (including plants and animals). While the number of cells in plants and animals varies from species to species, humans contain more than 10 trillion (1013) cells.{{sfn|Alberts|p=2}} Most plant and animal cells are visible only under a microscope, with dimensions between 1 and 100 micrometres.BOOK, Campbell, Neil A., Brad Williamson, Robin J. Heyden, Biology: Exploring Life, Pearson Prentice Hall, 2006, Boston, Massachusetts,weblink 0-13-250882-6, Cells were discovered by Robert Hooke in 1665, who named them for their resemblance to cells inhabited by Christian monks in a monastery.BOOK, Karp, Gerald, Cell and Molecular Biology: Concepts and Experiments, 19 October 2009, John Wiley & Sons, 9780470483374, 2, Hooke called the pores cells because they reminded him of the cells inhabited by monks living in a monastery., BOOK, Achiever's Biology, 1990, Allied Publishers, 9788184243697, 36, In 1665, an Englishman, Robert Hooke observed a thin slice of" cork under a simple microscope. (A simple microscope is a microscope with only one biconvex lens, rather like a magnifying glass). He saw many small box like structures. These reminded him of small rooms called "cells" in which Christian monks lived and meditated., Alan Chong, Tero, vanc, Cell theory, first developed in 1839 by Matthias Jakob Schleiden and Theodor Schwann, states that all organisms are composed of one or more cells, that cells are the fundamental unit of structure and function in all living organisms, and that all cells come from pre-existing cells.BOOK, Maton, Anthea, vanc, Cells Building Blocks of Life, Prentice Hall, 1997, New Jersey, 0-13-423476-6, Cells emerged on Earth at least 3.5 billion years ago.

Overview

Cells are of two types: eukaryotic, which contain a nucleus, and prokaryotic, which do not. Prokaryotes are single-celled organisms, while eukaryotes can be either single-celled or multicellular.

Prokaryotic cells

File:Average prokaryote cell- en.svg|thumb|300px|right|Structure of a typical prokaryoticprokaryoticProkaryotes include bacteria and archaea, two of the three domains of life. Prokaryotic cells were the first form of life on Earth, characterised by having vital biological processes including cell signaling. They are simpler and smaller than eukaryotic cells, and lack membrane-bound organelles such as a nucleus. The DNA of a prokaryotic cell consists of a single chromosome that is in direct contact with the cytoplasm. The nuclear region in the cytoplasm is called the nucleoid. Most prokaryotes are the smallest of all organisms ranging from 0.5 to 2.0 Âµm in diameter.Microbiology : Principles and Explorations By Jacquelyn G. BlackA prokaryotic cell has three architectural regions:
  • Enclosing the cell is the cell envelope – generally consisting of a plasma membrane covered by a cell wall which, for some bacteria, may be further covered by a third layer called a capsule. Though most prokaryotes have both a cell membrane and a cell wall, there are exceptions such as Mycoplasma (bacteria) and Thermoplasma (archaea) which only possess the cell membrane layer. The envelope gives rigidity to the cell and separates the interior of the cell from its environment, serving as a protective filter. The cell wall consists of peptidoglycan in bacteria, and acts as an additional barrier against exterior forces. It also prevents the cell from expanding and bursting (cytolysis) from osmotic pressure due to a hypotonic environment. Some eukaryotic cells (plant cells and fungal cells) also have a cell wall.
  • Inside the cell is the cytoplasmic region that contains the genome (DNA), ribosomes and various sorts of inclusions.{{NCBI-scienceprimer|article=What Is a Cell?|url=https://web.archive.org/web/20130503014839weblink|access-date=3 May 2013}} 30 March 2004. The genetic material is freely found in the cytoplasm. Prokaryotes can carry extrachromosomal DNA elements called plasmids, which are usually circular. Linear bacterial plasmids have been identified in several species of spirochete bacteria, including members of the genus Borrelia notably Borrelia burgdorferi, which causes Lyme disease.European Bioinformatics Institute, Karyn's Genomes: Borrelia burgdorferi, part of 2can on the EBI-EMBL database. Retrieved 5 August 2012 Though not forming a nucleus, the DNA is condensed in a nucleoid. Plasmids encode additional genes, such as antibiotic resistance genes.
  • On the outside, flagella and pili project from the cell's surface. These are structures (not present in all prokaryotes) made of proteins that facilitate movement and communication between cells.
(File:Animal cell structure en.svg|thumb|Structure of a typical animal cell)File:Plant cell structure-en.svg|thumb|Structure of a typical plant cellplant cell

Eukaryotic cells

Plants, animals, fungi, slime moulds, protozoa, and algae are all eukaryotic. These cells are about fifteen times wider than a typical prokaryote and can be as much as a thousand times greater in volume. The main distinguishing feature of eukaryotes as compared to prokaryotes is compartmentalization: the presence of membrane-bound organelles (compartments) in which specific activities take place. Most important among these is a cell nucleus, an organelle that houses the cell's DNA. This nucleus gives the eukaryote its name, which means "true kernel (nucleus)". Other differences include:
  • The plasma membrane resembles that of prokaryotes in function, with minor differences in the setup. Cell walls may or may not be present.
  • The eukaryotic DNA is organized in one or more linear molecules, called chromosomes, which are associated with histone proteins. All chromosomal DNA is stored in the cell nucleus, separated from the cytoplasm by a membrane. Some eukaryotic organelles such as mitochondria also contain some DNA.
  • Many eukaryotic cells are ciliated with primary cilia. Primary cilia play important roles in chemosensation, mechanosensation, and thermosensation. Cilia may thus be "viewed as a sensory cellular antennae that coordinates a large number of cellular signaling pathways, sometimes coupling the signaling to ciliary motility or alternatively to cell division and differentiation."JOURNAL, Satir P, Christensen ST, Structure and function of mammalian cilia, Histochemistry and Cell Biology, 129, 6, 687–93, June 2008, 18365235, 2386530, 10.1007/s00418-008-0416-9,weblink Springer Berlin/Heidelberg, Søren T. Christensen, 1432-119X,
  • Motile eukaryotes can move using motile cilia or flagella. Motile cells are absent in conifers and flowering plants.PH Raven, Evert RF, Eichhorm SE (1999) Biology of Plants, 6th edition. WH Freeman, New York Eukaryotic flagella are less complex than those of prokaryotes.
{| class="wikitable" style="margin-left: auto; margin-right: auto;"|+Comparison of features of prokaryotic and eukaryotic cells!!Prokaryotes!Eukaryotes!Typical organismsbacterium>bacteria, archaeaprotists, fungus>fungi, plants, animals!Typical sizeMicrometre>µmCAMPBELL BIOLOGY—CONCEPTS AND CONNECTIONS > PUBLISHER=PEARSON EDUCATION PAGE=320, |~ 10–100 Âµm!Type of nucleus|nucleoid region; no true nucleus|true nucleus with double membrane!DNA|circular (usually)|linear molecules (chromosomes) with histone proteins!RNA/protein synthesis|coupled in the cytoplasmTranscription (genetics)>RNA synthesis in the nucleusprotein synthesis in the cytoplasm!Ribosomes|50S and 30S|60S and 40S!Cytoplasmic structure|very few structuresendomembrane system>endomembranes and a cytoskeleton!Cell movementFlagellum>flagella made of flagellinCilium>cilia containing microtubules; lamellipodia and filopodia containing actin!Mitochondria|none|one to several thousand!Chloroplasts|none|in algae and plants!Organization|usually single cells|single cells, colonies, higher multicellular organisms with specialized cells!Cell division|binary fission (simple division)|mitosis (fission or budding) meiosis!Chromosomes|single chromosome|more than one chromosome!Membranes|cell membrane|Cell membrane and membrane-bound organelles

Subcellular components

All cells, whether prokaryotic or eukaryotic, have a membrane that envelops the cell, regulates what moves in and out (selectively permeable), and maintains the electric potential of the cell. Inside the membrane, the cytoplasm takes up most of the cell's volume. All cells (except red blood cells which lack a cell nucleus and most organelles to accommodate maximum space for hemoglobin) possess DNA, the hereditary material of genes, and RNA, containing the information necessary to build various proteins such as enzymes, the cell's primary machinery. There are also other kinds of biomolecules in cells. This article lists these primary cellular components, then briefly describes their function.

Membrane

(File: Cell membrane detailed diagram en.svg|thumb|Detailed diagram of lipid bilayer cell membrane)The cell membrane, or plasma membrane, is a biological membrane that surrounds the cytoplasm of a cell. In animals, the plasma membrane is the outer boundary of the cell, while in plants and prokaryotes it is usually covered by a cell wall. This membrane serves to separate and protect a cell from its surrounding environment and is made mostly from a double layer of phospholipids, which are amphiphilic (partly hydrophobic and partly hydrophilic). Hence, the layer is called a phospholipid bilayer, or sometimes a fluid mosaic membrane. Embedded within this membrane is a variety of protein molecules that act as channels and pumps that move different molecules into and out of the cell. The membrane is semi-permeable, and selectively permeable, in that it can either let a substance (molecule or ion) pass through freely, pass through to a limited extent or not pass through at all. Cell surface membranes also contain receptor proteins that allow cells to detect external signaling molecules such as hormones.

Cytoskeleton

File:DAPIMitoTrackerRedAlexaFluor488BPAE.jpg|thumb|A fluorescent image of an endothelial cell. Nuclei are stained blue, mitochondriamitochondriaThe cytoskeleton acts to organize and maintain the cell's shape; anchors organelles in place; helps during endocytosis, the uptake of external materials by a cell, and cytokinesis, the separation of daughter cells after cell division; and moves parts of the cell in processes of growth and mobility. The eukaryotic cytoskeleton is composed of microfilaments, intermediate filaments and microtubules. There are a great number of proteins associated with them, each controlling a cell's structure by directing, bundling, and aligning filaments. The prokaryotic cytoskeleton is less well-studied but is involved in the maintenance of cell shape, polarity and cytokinesis.JOURNAL, Michie KA, Löwe J, Dynamic filaments of the bacterial cytoskeleton, Annual Review of Biochemistry, 75, 467–92, 2006, 16756499, 10.1146/annurev.biochem.75.103004.142452, The subunit protein of microfilaments is a small, monomeric protein called actin. The subunit of microtubules is a dimeric molecule called tubulin. Intermediate filaments are heteropolymers whose subunits vary among the cell types in different tissues. But some of the subunit protein of intermediate filaments include vimentin, desmin, lamin (lamins A, B and C), keratin (multiple acidic and basic keratins), neurofilament proteins (NF–L, NF–M).

Genetic material

Two different kinds of genetic material exist: deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). Cells use DNA for their long-term information storage. The biological information contained in an organism is encoded in its DNA sequence. RNA is used for information transport (e.g., mRNA) and enzymatic functions (e.g., ribosomal RNA). Transfer RNA (tRNA) molecules are used to add amino acids during protein translation.Prokaryotic genetic material is organized in a simple circular bacterial chromosome in the nucleoid region of the cytoplasm. Eukaryotic genetic material is divided into different, linear molecules called chromosomes inside a discrete nucleus, usually with additional genetic material in some organelles like mitochondria and chloroplasts (see endosymbiotic theory).A human cell has genetic material contained in the cell nucleus (the nuclear genome) and in the mitochondria (the mitochondrial genome). In humans the nuclear genome is divided into 46 linear DNA molecules called chromosomes, including 22 homologous chromosome pairs and a pair of sex chromosomes. The mitochondrial genome is a circular DNA molecule distinct from the nuclear DNA. Although the mitochondrial DNA is very small compared to nuclear chromosomes, it codes for 13 proteins involved in mitochondrial energy production and specific tRNAs.Foreign genetic material (most commonly DNA) can also be artificially introduced into the cell by a process called transfection. This can be transient, if the DNA is not inserted into the cell's genome, or stable, if it is. Certain viruses also insert their genetic material into the genome.

Organelles

Organelles are parts of the cell which are adapted and/or specialized for carrying out one or more vital functions, analogous to the organs of the human body (such as the heart, lung, and kidney, with each organ performing a different function). Both eukaryotic and prokaryotic cells have organelles, but prokaryotic organelles are generally simpler and are not membrane-bound.There are several types of organelles in a cell. Some (such as the nucleus and golgi apparatus) are typically solitary, while others (such as mitochondria, chloroplasts, peroxisomes and lysosomes) can be numerous (hundreds to thousands). The cytosol is the gelatinous fluid that fills the cell and surrounds the organelles.

Eukaryotic

File:HeLa Hoechst 33258.jpg|thumb|Human cancer cells, specifically HeLa cells, with DNA stained blue. The central and rightmost cell are in interphase, so their DNA is diffuse and the entire nuclei are labelled. The cell on the left is going through mitosismitosis
  • Cell nucleus: A cell's information center, the cell nucleus is the most conspicuous organelle found in a eukaryotic cell. It houses the cell's chromosomes, and is the place where almost all DNA replication and RNA synthesis (transcription) occur. The nucleus is spherical and separated from the cytoplasm by a double membrane called the nuclear envelope. The nuclear envelope isolates and protects a cell's DNA from various molecules that could accidentally damage its structure or interfere with its processing. During processing, DNA is transcribed, or copied into a special RNA, called messenger RNA (mRNA). This mRNA is then transported out of the nucleus, where it is translated into a specific protein molecule. The nucleolus is a specialized region within the nucleus where ribosome subunits are assembled. In prokaryotes, DNA processing takes place in the cytoplasm.
  • Mitochondria and Chloroplasts: generate energy for the cell. Mitochondria are self-replicating organelles that occur in various numbers, shapes, and sizes in the cytoplasm of all eukaryotic cells. Respiration occurs in the cell mitochondria, which generate the cell's energy by oxidative phosphorylation, using oxygen to release energy stored in cellular nutrients (typically pertaining to glucose) to generate ATP. Mitochondria multiply by binary fission, like prokaryotes. Chloroplasts can only be found in plants and algae, and they capture the sun's energy to make carbohydrates through photosynthesis.
File:Endomembrane system diagram en.svg|thumb|Diagram of the endomembrane systemendomembrane system
  • Endoplasmic reticulum: The endoplasmic reticulum (ER) is a transport network for molecules targeted for certain modifications and specific destinations, as compared to molecules that float freely in the cytoplasm. The ER has two forms: the rough ER, which has ribosomes on its surface that secrete proteins into the ER, and the smooth ER, which lacks ribosomes. The smooth ER plays a role in calcium sequestration and release.
  • Golgi apparatus: The primary function of the Golgi apparatus is to process and package the macromolecules such as proteins and lipids that are synthesized by the cell.
  • Lysosomes and Peroxisomes: Lysosomes contain digestive enzymes (acid hydrolases). They digest excess or worn-out organelles, food particles, and engulfed viruses or bacteria. Peroxisomes have enzymes that rid the cell of toxic peroxides. The cell could not house these destructive enzymes if they were not contained in a membrane-bound system.
  • Centrosome: the cytoskeleton organiser: The centrosome produces the microtubules of a cell – a key component of the cytoskeleton. It directs the transport through the ER and the Golgi apparatus. Centrosomes are composed of two centrioles, which separate during cell division and help in the formation of the mitotic spindle. A single centrosome is present in the animal cells. They are also found in some fungi and algae cells.
  • Vacuoles: Vacuoles sequester waste products and in plant cells store water. They are often described as liquid filled space and are surrounded by a membrane. Some cells, most notably Amoeba, have contractile vacuoles, which can pump water out of the cell if there is too much water. The vacuoles of plant cells and fungal cells are usually larger than those of animal cells.

Eukaryotic and prokaryotic

  • Ribosomes: The ribosome is a large complex of RNA and protein molecules. They each consist of two subunits, and act as an assembly line where RNA from the nucleus is used to synthesise proteins from amino acids. Ribosomes can be found either floating freely or bound to a membrane (the rough endoplasmatic reticulum in eukaryotes, or the cell membrane in prokaryotes).JOURNAL, Ménétret JF, Schaletzky J, Clemons WM, Osborne AR, SkÃ¥nland SS, Denison C, Gygi SP, Kirkpatrick DS, Park E, Ludtke SJ, Rapoport TA, Akey CW, Ribosome binding of a single copy of the SecY complex: implications for protein translocation, Molecular Cell, 28, 6, 1083–92, December 2007, 18158904, 10.1016/j.molcel.2007.10.034,

Structures outside the cell membrane

Many cells also have structures which exist wholly or partially outside the cell membrane. These structures are notable because they are not protected from the external environment by the semipermeable cell membrane. In order to assemble these structures, their components must be carried across the cell membrane by export processes.

Cell wall

Many types of prokaryotic and eukaryotic cells have a cell wall. The cell wall acts to protect the cell mechanically and chemically from its environment, and is an additional layer of protection to the cell membrane. Different types of cell have cell walls made up of different materials; plant cell walls are primarily made up of cellulose, fungi cell walls are made up of chitin and bacteria cell walls are made up of peptidoglycan.

Prokaryotic

Capsule

A gelatinous capsule is present in some bacteria outside the cell membrane and cell wall. The capsule may be polysaccharide as in pneumococci, meningococci or polypeptide as Bacillus anthracis or hyaluronic acid as in streptococci.Capsules are not marked by normal staining protocols and can be detected by India ink or methyl blue; which allows for higher contrast between the cells for observation.BOOK,weblink Prokaryotes, Newnes, Apr 11, 1996, 9780080984735, {{rp|87}}

Flagella

Flagella are organelles for cellular mobility. The bacterial flagellum stretches from cytoplasm through the cell membrane(s) and extrudes through the cell wall. They are long and thick thread-like appendages, protein in nature. A different type of flagellum is found in archaea and a different type is found in eukaryotes.

Fimbria

A fimbria also known as a pilus is a short, thin, hair-like filament found on the surface of bacteria. Fimbriae, or pili are formed of a protein called pilin (antigenic) and are responsible for attachment of bacteria to specific receptors of human cell (cell adhesion). There are special types of specific pili involved in bacterial conjugation.

Cellular processes

File:Three cell growth types.svg|thumb|Prokaryotes divide by binary fission, while eukaryotes divide by mitosis or meiosismeiosis

Replication

Cell division involves a single cell (called a mother cell) dividing into two daughter cells. This leads to growth in multicellular organisms (the growth of tissue) and to procreation (vegetative reproduction) in unicellular organisms. Prokaryotic cells divide by binary fission, while eukaryotic cells usually undergo a process of nuclear division, called mitosis, followed by division of the cell, called cytokinesis. A diploid cell may also undergo meiosis to produce haploid cells, usually four. Haploid cells serve as gametes in multicellular organisms, fusing to form new diploid cells.DNA replication, or the process of duplicating a cell's genome, always happens when a cell divides through mitosis or binary fission. This occurs during the S phase of the cell cycle.In meiosis, the DNA is replicated only once, while the cell divides twice. DNA replication only occurs before meiosis I. DNA replication does not occur when the cells divide the second time, in meiosis II.BOOK, Campbell Biology—Concepts and Connections, 2009, Pearson Education, 138, Replication, like all cellular activities, requires specialized proteins for carrying out the job.File:Catabolism schematic.svg|thumb|left|An outline of the catabolism of proteins, carbohydrates and fatfat

Growth and metabolism

File:Proteinsynthesis.png|thumb|An overview of protein synthesis.Within the nucleus of the cell (light blue), genes (DNA, dark blue) are transcribed into RNA. This RNA is then subject to post-transcriptional modification and control, resulting in a mature mRNA (red) that is then transported out of the nucleus and into the cytoplasm (peach), where it undergoes translation into a protein. mRNA is translated by ribosomes (purple) that match the three-base codons of the mRNA to the three-base anti-codons of the appropriate tRNA. Newly synthesized proteins (black) are often further modified, such as by binding to an effector molecule (orange), to become fully active.]]Between successive cell divisions, cells grow through the functioning of cellular metabolism. Cell metabolism is the process by which individual cells process nutrient molecules. Metabolism has two distinct divisions: catabolism, in which the cell breaks down complex molecules to produce energy and reducing power, and anabolism, in which the cell uses energy and reducing power to construct complex molecules and perform other biological functions.Complex sugars consumed by the organism can be broken down into simpler sugar molecules called monosaccharides such as glucose. Once inside the cell, glucose is broken down to make adenosine triphosphate (ATP), a molecule that possesses readily available energy, through two different pathways.

Protein synthesis

Cells are capable of synthesizing new proteins, which are essential for the modulation and maintenance of cellular activities. This process involves the formation of new protein molecules from amino acid building blocks based on information encoded in DNA/RNA. Protein synthesis generally consists of two major steps: transcription and translation.Transcription is the process where genetic information in DNA is used to produce a complementary RNA strand. This RNA strand is then processed to give messenger RNA (mRNA), which is free to migrate through the cell. mRNA molecules bind to protein-RNA complexes called ribosomes located in the cytosol, where they are translated into polypeptide sequences. The ribosome mediates the formation of a polypeptide sequence based on the mRNA sequence. The mRNA sequence directly relates to the polypeptide sequence by binding to transfer RNA (tRNA) adapter molecules in binding pockets within the ribosome. The new polypeptide then folds into a functional three-dimensional protein molecule.

Motility

Unicellular organisms can move in order to find food or escape predators. Common mechanisms of motion include flagella and cilia.In multicellular organisms, cells can move during processes such as wound healing, the immune response and cancer metastasis. For example, in wound healing in animals, white blood cells move to the wound site to kill the microorganisms that cause infection. Cell motility involves many receptors, crosslinking, bundling, binding, adhesion, motor and other proteins.WEB, Revathi, Ananthakrishnan, Allen, Ehrlicher, vanc,weblink The Forces Behind Cell Movement, Biolsci.org, 2009-04-17, The process is divided into three steps – protrusion of the leading edge of the cell, adhesion of the leading edge and de-adhesion at the cell body and rear, and cytoskeletal contraction to pull the cell forward. Each step is driven by physical forces generated by unique segments of the cytoskeleton.Alberts B, Johnson A, Lewis J. et al. Molecular Biology of the Cell, 4e. Garland Science. 2002JOURNAL, Ananthakrishnan R, Ehrlicher A, The forces behind cell movement, International Journal of Biological Sciences, 3, 5, 303–17, June 2007, 17589565, 1893118, 10.7150/ijbs.3.303,weblink

Multicellularity

Cell specialization

File:C elegans stained.jpg|thumb|Staining of a Caenorhabditis elegansCaenorhabditis elegansMulticellular organisms are organisms that consist of more than one cell, in contrast to single-celled organisms.BOOK, Becker, Wayne M., vanc, The world of the cell, Benjamin Cummings, Pearson Benjamin Cummings, 2009, 978-0-321-55418-5, 480, etal, In complex multicellular organisms, cells specialize into different cell types that are adapted to particular functions. In mammals, major cell types include skin cells, muscle cells, neurons, blood cells, fibroblasts, stem cells, and others. Cell types differ both in appearance and function, yet are genetically identical. Cells are able to be of the same genotype but of different cell type due to the differential expression of the genes they contain.Most distinct cell types arise from a single totipotent cell, called a zygote, that differentiates into hundreds of different cell types during the course of development. Differentiation of cells is driven by different environmental cues (such as cell–cell interaction) and intrinsic differences (such as those caused by the uneven distribution of molecules during division).

Origin of multicellularity

Multicellularity has evolved independently at least 25 times,JOURNAL, Grosberg RK, Strathmann RR,weblink The evolution of multicellularity: A minor major transition?, Annu Rev Ecol Evol Syst., 2007, 38, 621–654, including in some prokaryotes, like cyanobacteria, myxobacteria, actinomycetes, Magnetoglobus multicellularis or Methanosarcina. However, complex multicellular organisms evolved only in six eukaryotic groups: animals, fungi, brown algae, red algae, green algae, and plants.JOURNAL, Popper ZA, Michel G, Hervé C, Domozych DS, Willats WG, Tuohy MG, Kloareg B, Stengel DB, Evolution and diversity of plant cell walls: from algae to flowering plants, Annual Review of Plant Biology, 62, 567–90, 2011, 21351878, 10.1146/annurev-arplant-042110-103809,weblink It evolved repeatedly for plants (Chloroplastida), once or twice for animals, once for brown algae, and perhaps several times for fungi, slime molds, and red algae.JOURNAL, Bonner, John Tyler, vanc, John Tyler Bonner, 1998, The Origins of Multicellularity, Integrative Biology: Issues, News, and Reviews, 1, 1, 27–36,weblink PDF, 0.2 MB, 1093-4391, 10.1002/(SICI)1520-6602(1998)1:13.0.CO;2-6, yes,weblink" title="web.archive.org/web/20120308175112weblink">weblink March 8, 2012, Multicellularity may have evolved from colonies of interdependent organisms, from cellularization, or from organisms in symbiotic relationships.The first evidence of multicellularity is from cyanobacteria-like organisms that lived between 3 and 3.5 billion years ago. Other early fossils of multicellular organisms include the contested Grypania spiralis and the fossils of the black shales of the Palaeoproterozoic Francevillian Group Fossil B Formation in Gabon.JOURNAL, El Albani A, Bengtson S, Canfield DE, Bekker A, Macchiarelli R, Mazurier A, Hammarlund EU, Boulvais P, Dupuy JJ, Fontaine C, Fürsich FT, Gauthier-Lafaye F, Janvier P, Javaux E, Ossa FO, Pierson-Wickmann AC, Riboulleau A, Sardini P, Vachard D, Whitehouse M, Meunier A, Large colonial organisms with coordinated growth in oxygenated environments 2.1 Gyr ago, Nature, 466, 7302, 100–4, July 2010, 20596019, 10.1038/nature09166, Abderrazak El Albani, 2010Natur.466..100A, The evolution of multicellularity from unicellular ancestors has been replicated in the laboratory, in evolution experiments using predation as the selective pressure.

Origins

The origin of cells has to do with the origin of life, which began the history of life on Earth.

Origin of the first cell

File:Stromatolites.jpg|thumb|Stromatolites are left behind by cyanobacteria, also called blue-green algae. They are the oldest known fossils of life on Earth. This one-billion-year-old fossil is from Glacier National Park in the United States.]]{{further|Abiogenesis|Evolution of cells}}There are several theories about the origin of small molecules that led to life on the early Earth. They may have been carried to Earth on meteorites (see Murchison meteorite), created at deep-sea vents, or synthesized by lightning in a reducing atmosphere (see Miller–Urey experiment). There is little experimental data defining what the first self-replicating forms were. RNA is thought to be the earliest self-replicating molecule, as it is capable of both storing genetic information and catalyzing chemical reactions (see RNA world hypothesis), but some other entity with the potential to self-replicate could have preceded RNA, such as clay or peptide nucleic acid.JOURNAL, Orgel LE, The origin of life--a review of facts and speculations, Trends in Biochemical Sciences, 23, 12, 491–5, December 1998, 9868373, 10.1016/S0968-0004(98)01300-0, Cells emerged at least 3.5 billion years ago.JOURNAL, Schopf JW, Kudryavtsev AB, Czaja AD, Tripathi AB, 2007, Evidence of Archean life: Stromatolites and microfossils, Precambrian Research, 158, 141–155, JOURNAL, Schopf JW, 2006, Fossil evidence of Archaean life, Philos Trans R Soc Lond B Biol Sci, 29, 361(1470), 869–885, BOOK, Peter Hamilton, Raven, George Brooks, Johnson, vanc, Biology,weblink 7 July 2013, 2002, McGraw-Hill Education, 978-0-07-112261-0, 68, The current belief is that these cells were heterotrophs. The early cell membranes were probably more simple and permeable than modern ones, with only a single fatty acid chain per lipid. Lipids are known to spontaneously form bilayered vesicles in water, and could have preceded RNA, but the first cell membranes could also have been produced by catalytic RNA, or even have required structural proteins before they could form.JOURNAL, Griffiths G, Cell evolution and the problem of membrane topology, Nature Reviews. Molecular Cell Biology, 8, 12, 1018–24, December 2007, 17971839, 10.1038/nrm2287,

Origin of eukaryotic cells

{{further|Evolution of sexual reproduction}}The eukaryotic cell seems to have evolved from a symbiotic community of prokaryotic cells. DNA-bearing organelles like the mitochondria and the chloroplasts are descended from ancient symbiotic oxygen-breathing proteobacteria and cyanobacteria, respectively, which were endosymbiosed by an ancestral archaean prokaryote.There is still considerable debate about whether organelles like the hydrogenosome predated the origin of mitochondria, or vice versa: see the hydrogen hypothesis for the origin of eukaryotic cells.

History of research

File:RobertHookeMicrographia1665.jpg|thumb|Hooke's drawing of cells in cork, 1665]]
  • 1632–1723: Antonie van Leeuwenhoek teaches himself to make lenses, constructs basic optical microscopes and draws protozoa, such as Vorticella from rain water, and bacteria from his own mouth.
  • 1665: Robert Hooke discovers cells in cork, then in living plant tissue using an early compound microscope. He coins the term cell (from Latin cella, meaning "small room") in his book Micrographia (1665).BOOK, Hooke, Robert, vanc, Micrographia: …, 1665, Royal Society of London, London, England, 113,weblink " … I could exceedingly plainly perceive it to be all perforated and porous, much like a Honey-comb, but that the pores of it were not regular […] these pores, or cells, […] were indeed the first microscopical pores I ever saw, and perhaps, that were ever seen, for I had not met with any Writer or Person, that had made any mention of them before this … " – Hooke describing his observations on a thin slice of cork. See also:


See also

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References

{{Reflist}}

Further reading

  • BOOK, Alberts, Bruce, Johnson, Alexander, Lewis, Julian, Morgan, David, Raff, Martin, Roberts, Keith, Walter, Peter, vanc, 2015, Molecular Biology of the Cell, 6th, Garland Science, 2, 978-0815344322, {{sfnRef, Alberts, }}
  • BOOK, Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P, Molecular Biology of the Cell, 6th, Garland, 2014,weblink 9780815344322, ; The fourth edition is freely available from National Center for Biotechnology Information Bookshelf.
  • BOOK, Lodish H, Berk A, Matsudaira P, Kaiser CA, Krieger M, Scott MP, Zipurksy SL, Darnell J, Molecular Cell Biology, 5th, WH Freeman: New York, NY, 2004,weblink 978-0-7167-4366-8,
  • BOOK, Cooper GM, The cell: a molecular approach, 2nd, ASM Press, Washington, D.C, 2000, 0-87893-102-3,weblink

External links

{{Commons category|Cell biology}} {{Cellular structures}}{{Biological organisation}}{{Authority control}}

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