blood pressure

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blood pressure
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{{Other uses|Blood pressure (disambiguation)}}

| HCPCSlevel2 =| OPS301 =| reference_range =}}Blood pressure (BP) is the pressure of circulating blood on the walls of blood vessels. Most of this pressure is due to work done by the heart by pumping blood through the circulatory system. Used without further specification, "blood pressure" usually refers to the pressure in large arteries of the systemic circulation. Blood pressure is usually expressed in terms of the systolic pressure (maximum during one heartbeat) over diastolic pressure (minimum in between two heartbeats) and is measured in millimeters of mercury (mmHg), above the surrounding atmospheric pressure.Blood pressure is one of the vital signs, along with respiratory rate, heart rate, oxygen saturation, and body temperature. Normal resting blood pressure in an adult is approximately {{convert|120|mmHg}} systolic, and {{convert|80|mmHg}} diastolic, abbreviated "120/80 mmHg". Globally, the average blood pressure, age standardized, has remained about the same since 1975 to the present, at approx. 127/79 mmHg in men and 122/77 mmHg in women.JOURNAL, Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants, The Lancet, January 2017, 389, 10064, 37-55,weblink Traditionally, blood pressure was measured non-invasively using ausculation with a mercury-tube sphygmomanometer. Ausculation is still generally considered to be the gold standard of accuracy for non-invasive blood pressure readings in clinic.JOURNAL, Grim CE, Grim CM, Auscultatory BP: still the gold standard, Journal of the American Society of Hypertension, 10, 3, 191–3, March 2016, 26839183, 10.1016/j.jash.2016.01.004, However, semi-automated methods have become common, largely due to concerns about potential mercury toxicity,JOURNAL, O'Brien E, Blood pressure measurement is changing!, Heart, 85, 1, 3–5, January 2001, 11119446, 1729570, 10.1136/heart.85.1.3, although cost, ease of use and applicability to ambulatory blood pressure or home blood pressure measurements have also influenced this trend.JOURNAL, Ogedegbe G, Pickering T, Principles and techniques of blood pressure measurement, Cardiology Clinics, 28, 4, 571–86, November 2010, 20937442, 3639494, 10.1016/j.ccl.2010.07.006, Early automated alternatives to mercury-tube sphygmomanometers were often seriously inaccurate, but modern devices validated to international standards achieve an average difference between two standardized reading methods of 5 mm Hg or less and a standard deviation of less than 8 mm Hg. Most of these semi-automated methods measure blood pressure using oscillometry.JOURNAL, Alpert BS, Quinn D, Gallick D, Oscillometric blood pressure: a review for clinicians, Journal of the American Society of Hypertension, 8, 12, 930–8, December 2014, 25492837, 10.1016/j.jash.2014.08.014, Blood pressure is influenced by cardiac output, total peripheral resistance and arterial stiffness and varies depending on situation, emotional state, activity, and relative health/disease states. In the short term, blood pressure is regulated by baroreceptors which act via the brain to influence the nervous and the endocrine systems.Blood pressure that is too low is called hypotension, and pressure that is consistently high is hypertension. Both have many causes and may be of sudden onset or of long duration. Long-term hypertension is a risk factor for many diseases, including heart disease, stroke and kidney failure. Long-term hypertension is more common than long-term hypotension, which is usually only diagnosed when it causes symptoms.{{TOC limit|3}}

Classification, normal and abnormal values

Systemic arterial pressure {| class"wikitable" style "float: right; margin-left:15px; text-align:center"|+The Task Force for the management of arterial hypertension of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH) classification of office blood pressure (BP)a and definitions of hypertension gradeb. The same classification is used for all ages from 16 years.

a BP category is defined according to seated clinic BP and by the highest level of BP, whether systolic or diastolic.b Isolated systolic hypertension is graded 1, 2, or 3 according to systolic BP values in the ranges indicated.! Category! systolic BP, mmHg! diastolic BP, mmHg!Optimal| < 120| < 80!Normal| 120–129| 80–84!High normal| 130–139|85–89!Grade 1 hypertension| 140–159|90–99!Grade 2 hypertension| 160–179| 100–109!Grade 3 hypertension| ≥ 180| ≥ 110!Isolated systolic hypertensionb| ≥ 140| < 90The risk of cardiovascular disease increases progressively above 115/75 mmHg,JOURNAL, Appel LJ, Brands MW, Daniels SR, Karanja N, Elmer PJ, Sacks FM, Dietary approaches to prevent and treat hypertension: a scientific statement from the American Heart Association, Hypertension, 47, 2, 296–308, February 2006, 16434724, 10.1161/01.HYP.0000202568.01167.B6,, below this level there is limited evidence.JOURNAL, Lewington S, Clarke R, Qizilbash N, Peto R, Collins R, Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies, Lancet, 360, 9349, 1903–13, December 2002, 12493255, 10.1016/S0140-6736(02)11911-8, Observational studies demonstrate that people who maintain arterial pressures at the low end of these pressure ranges have much better long-term cardiovascular health. There is an ongoing medical debate over what is the optimal level of blood pressure to target when using drugs to lower blood pressure with hypertension, particularly in older people.JOURNAL, Yusuf S, Lonn E, The SPRINT and the HOPE-3 Trial in the Context of Other Blood Pressure-Lowering Trials, JAMA Cardiology, 1, 8, 857–858, November 2016, 27602555, 10.1001/jamacardio.2016.2169, The table shows the most recent classification (2018) of office (or clinic) blood pressure by The Task Force for the management of arterial hypertension of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH).JOURNAL, Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, Clement DL, Coca A, de Simone G, Dominiczak A, Kahan T, Mahfoud F, Redon J, Ruilope L, Zanchetti A, Kerins M, Kjeldsen SE, Kreutz R, Laurent S, Lip GY, McManus R, Narkiewicz K, Ruschitzka F, Schmieder RE, Shlyakhto E, Tsioufis C, Aboyans V, Desormais I, 6, 2018 ESC/ESH Guidelines for the management of arterial hypertension, European Heart Journal, 39, 33, 3021–3104, September 2018, 30165516, 10.1093/eurheartj/ehy339, Similar thresholds had been adopted by the American Heart Association for adults who are 18 years and older,WEB,weblink Understanding blood pressure readings, 11 January 2011, American Heart Association, 30 March 2011, but in November 2017 the American Heart Association announced revised definitions for blood pressure categories that increased the number of people considered to have high blood pressure.WEB,weblink Nearly half of US adults could now be classified with high blood pressure, under new definitions, 13 November 2017, American Heart Association, 14 November 2017, Blood pressure fluctuates from minute to minute and normally shows a circadian rhythm over a 24-hour period,JOURNAL, Smolensky MH, Hermida RC, Portaluppi F, Circadian mechanisms of 24-hour blood pressure regulation and patterning, Sleep Medicine Reviews, 33, 4–16, June 2017, 27076261, 10.1016/j.smrv.2016.02.003, with highest readings in the early morning and evenings and lowest readings at night.JOURNAL, van Berge-Landry HM, Bovbjerg DH, James GD, Relationship between waking-sleep blood pressure and catecholamine changes in African-American and European-American women, Blood Pressure Monitoring, 13, 5, 257–62, October 2008, 18799950, 2655229, 10.1097/MBP.0b013e3283078f45, Table2: Comparison of ambulatory blood pressures and urinary norepinephrine and epinephrine excretion measured at work, home, and during sleep between European–American (n = 110) and African–American (n = 51) women, JOURNAL, van Berge-Landry HM, Bovbjerg DH, James GD, Relationship between waking-sleep blood pressure and catecholamine changes in African-American and European-American women, Blood Pressure Monitoring, 13, 5, 257–62, October 2008, 18799950, 2655229, 10.1097/MBP.0b013e3283078f45, NIHMS90092, Loss of the normal fall in blood pressure at night is associated with a greater future risk of cardiovascular disease and there is evidence that night-time blood pressure is a stronger predictor of cardiovascular events than day-time blood pressure.JOURNAL, Hansen TW, Li Y, Boggia J, Thijs L, Richart T, Staessen JA, Predictive role of the nighttime blood pressure, Hypertension, 57, 1, 3–10, January 2011, 21079049, 10.1161/HYPERTENSIONAHA.109.133900, Blood pressure varies over longer time periods (months to years) and this variability predicts adverse outcomes.JOURNAL, Rothwell PM, Does blood pressure variability modulate cardiovascular risk?, Current Hypertension Reports, 13, 3, 177–86, June 2011, 21465141, 10.1007/s11906-011-0201-3, Blood pressure also changes in response to temperature, noise, emotional stress, consumption of food or liquid, dietary factors, physical activity, changes in posture, such as standing-up, drugs, and disease.BOOK, Temporal Variations of the Cardiovascular System, H.), Schmidt, T. F. H. (Thomas F., 1992, Springer Berlin Heidelberg, Engel, Bernard T., Blümchen, Gerhard., 9783662027486, Berlin, Heidelberg, 851391490, The variability in blood pressure and the better predictive value of ambulatory blood pressure measurements has led to some authorities, such as The National Institute for Health and Care Excellence (NICE) in UK, to advocate the use of ambulatory blood pressure as the preferred method for diagnosis of hypertension.BOOK,weblink Hypertension: The Clinical Management of Primary Hypertension in Adults: Update of Clinical Guidelines 18 and 34, National Clinical Guideline Centre (UK), 2011, Royal College of Physicians (UK), National Institute for Health and Clinical Excellence: Guidance, London, 22855971, Various other factors, such as age and sex, also influence a person's blood pressure. Differences between left and right arm blood pressure measurements tend to be small. However, occasionally there is a consistent difference greater than 10 mmHg which may need further investigation, e.g. for peripheral arterial disease or obstructive arterial disease.JOURNAL, Eguchi K, Yacoub M, Jhalani J, Gerin W, Schwartz JE, Pickering TG, February 2007, Consistency of blood pressure differences between the left and right arms, Arch Intern Med, 167, 4, 388–93, 10.1001/archinte.167.4.388, 17325301, JOURNAL, Agarwal R, Bunaye Z, Bekele DM, March 2008, Prognostic significance of between-arm blood pressure differences, Hypertension, 51, 3, 657–62, 10.1161/HYPERTENSIONAHA.107.104943, 18212263, JOURNAL, Clark, C. E., Campbell, J. L., Evans, P. H., Millward, A., December 2006, Prevalence and clinical implications of the inter-arm blood pressure difference: A systematic review, Journal of Human Hypertension, 20, 12, 923–931, 10.1038/sj.jhh.1002093, 0950-9240, 17036043, There is no accepted diagnostic standard for hypotension, although pressures less than 90/60 are commonly regarded as hypotensive.BOOK,weblink Hypotension, Sharma, Sandeep, Bhattacharya, Priyanka T., 2018, StatPearls, StatPearls Publishing, 29763136, vanc, 2018-12-23, In practice blood pressure is considered too low only if symptoms are present.WEB,weblink Low blood pressure (hypotension) – Causes, Mayo Clinic staff, 2009-05-23,, Mayo Foundation for Medical Education and Research, 2010-10-19,

Systemic arterial pressure and age

Fetal blood pressure

{{Further|Fetal circulation#Blood pressure}}In pregnancy, it is the fetal heart and not the mother's heart that builds up the fetal blood pressure to drive blood through the fetal circulation. The blood pressure in the fetal aorta is approximately 30 mmHg at 20 weeks of gestation, and increases to approximately 45 mmHg at 40 weeks of gestation.JOURNAL, Struijk PC, Mathews VJ, Loupas T, Stewart PA, Clark EB, Steegers EA, Wladimiroff JW, October 2008, Blood pressure estimation in the human fetal descending aorta, Ultrasound Obstet Gynecol, 32, 5, 673–81, 10.1002/uog.6137, 18816497, The average blood pressure for full-term infants:BOOK, Foundations of Maternal-Newborn Nursing, Sharon SM, Emily SM, 2006, Elsevier, 4th, Philadelphia, 476,
  • Systolic 65–95 mmHg
  • Diastolic 30–60 mmHg
Pediatric Age Specific, p. 6. Revised 6/10. By Theresa Kirkpatrick and Kateri Tobias. UCLA Health System">

Childhood {| class"wikitable" style "float: right; margin-left:15px; text-align:center"|+Reference ranges for blood pressure (BP) in childrenPediatric Age Specific, p. 6. Revised 6/10. By Theresa Kirkpatrick and Kateri Tobias. UCLA Health System

!Stage!!Approximate age!!Systolic BP, mmHg!!Diastolic BP, mmHg! Infants| 50–70! Toddlers and preschoolers| 50–80! School age| 50–80! Adolescents| 60–90In children, the normal ranges for blood pressure are lower than for adults and depend on height.JOURNAL, National Heart, Lung and Blood Institute, Blood pressure tables for children and adolescents,weblink (Note that the median blood pressure is given by the 50th percentile and hypertension is defined by the 95th percentile for a given age, height, and sex.) Reference blood pressure values have been developed for children in different countries, based on the distribution of blood pressure in children of these countries.JOURNAL, Chiolero A, Mar 2014, The quest for blood pressure reference values in children, Journal of Hypertension, 32, 3, 477–79, 10.1097/HJH.0000000000000109, 24477093,

Aging adults

In adults in most societies, systolic blood pressure tends to rise from early adulthood onward, up to at least age 70;JOURNAL, Wills AK, Lawlor DA, Matthews FE, Sayer AA, Bakra E, Ben-Shlomo Y, Benzeval M, Brunner E, Cooper R, Kivimaki M, Kuh D, Muniz-Terrera G, Hardy R, June 2011, Life course trajectories of systolic blood pressure using longitudinal data from eight UK cohorts, PLoS Medicine, 8, 6, e1000440, 10.1371/journal.pmed.1000440, 3114857, 21695075, JOURNAL, Franklin SS, Gustin W, Wong ND, Larson MG, Weber MA, Kannel WB, Levy D, July 1997, Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study, Circulation, 96, 1, 308–15, 9236450, 10.1161/01.CIR.96.1.308, diastolic pressure tends to begin to rise at the same time but to start to fall earlier in mid-life, approximately age 55. Mean blood pressure rises from early adulthood, plateauing in mid-life, while pulse pressure rises quite markedly after the age of 40. Consequently, in many older people, systolic blood pressure often exceeds the normal adult range, if the diastolic pressure is in the normal range this is termed isolated systolic hypertension. The rise in pulse pressure with age is attributed to increased stiffness of the arteries.JOURNAL, Franklin SS, 2008-05-01, Beyond blood pressure: Arterial stiffness as a new biomarker of cardiovascular disease, Journal of the American Society of Hypertension, 2, 3, 140–51, 10.1016/j.jash.2007.09.002, 20409896, An age-related rise in blood pressure is not considered healthy and is not observed in some isolated unacculturated communities.JOURNAL, Gurven, Michael, Blackwell, Aaron D., Rodríguez, Daniel Eid, Stieglitz, Jonathan, Kaplan, Hillard, July 2012, Does blood pressure inevitably rise with age?: longitudinal evidence among forager-horticulturalists, Hypertension (Dallas, Tex.: 1979), 60, 1, 25–33, 10.1161/bgvvggg.111.189100, 1524-4563, 3392307, 22700319,

Systemic venous pressure

{{Non-systemic blood pressures}}Blood pressure generally refers to the arterial pressure in the systemic circulation. However, measurement of pressures in the venous system and the pulmonary vessels plays an important role in intensive care medicine but requires invasive measurement of pressure using a catheter.Venous pressure is the vascular pressure in a vein or in the atria of the heart. It is much less than arterial pressure, with common values of 5 mmHg in the right atrium and 8 mmHg in the left atrium.Variants of venous pressure include:
  • Central venous pressure, which is a good approximation of right atrial pressure,WEB,weblink Central Venous Catheter Physiology, 2009-02-27, yes,weblink" title="">weblink 2008-08-21, which is a major determinant of right ventricular end diastolic volume. (However, there can be exceptions in some cases.)JOURNAL, Tkachenko BI, Evlakhov VI, Poyasov IZ, Independence of changes in right atrial pressure and central venous pressure, Bull. Exp. Biol. Med., 134, 4, 318–20, 2002, 12533747, 10.1023/A:1021931508946,
  • The jugular venous pressure (JVP) is the indirectly observed pressure over the venous system. It can be useful in the differentiation of different forms of heart and lung disease.
  • The portal venous pressure is the blood pressure in the portal vein. It is normally 5–10 mmHgWEB,weblink Esophageal Varices : Article Excerpt by: Samy A Azer, eMedicine, 2011-08-22,

Pulmonary pressure

Normally, the pressure in the pulmonary artery is about 15 mmHg at rest.What Is Pulmonary Hypertension? From Diseases and Conditions Index (DCI). National Heart, Lung, and Blood Institute. Last updated September 2008. Retrieved on 6 April 2009.Increased blood pressure in the capillaries of the lung causes pulmonary hypertension, leading to interstitial edema if the pressure increases to above 20 mmHg, and to pulmonary edema at pressures above 25 mmHg.Chapter 41, p. 210 in: Cardiology secretsBy Olivia Vynn AdairEdition: 2, illustratedPublished by Elsevier Health Sciences, 2001{{ISBN|1-56053-420-6|978-1-56053-420-4}}

Mean systemic pressure

If the heart is stopped, blood pressure falls, but it does not fall to zero. The remaining pressure measured after cessation of the heart beat and redistribution of blood throughout the circulation is termed the mean systemic pressure or mean circulatory filling pressure;JOURNAL, Rothe, C. F., 1993, Mean circulatory filling pressure: its meaning and measurement, Journal of Applied Physiology, 74, 2, 499–509, 10.1152/jappl.1993.74.2.499, 8750-7587, 8458763, typically this is of the order of ~7mm Hg.

Disorders of blood pressure

Disorders of blood pressure control include high blood pressure, low blood pressure, and blood pressure that shows excessive or maladaptive fluctuation.

High blood pressure

(File:Main complications of persistent high blood pressure.svg|thumb|right|300px|Overview of main complications of persistent high blood pressure)Arterial hypertension can be an indicator of other problems and may have long-term adverse effects. Sometimes it can be an acute problem, for example hypertensive emergency.Levels of arterial pressure put mechanical stress on the arterial walls. Higher pressures increase heart workload and progression of unhealthy tissue growth (atheroma) that develops within the walls of arteries. The higher the pressure, the more stress that is present and the more atheroma tend to progress and the heart muscle tends to thicken, enlarge and become weaker over time.Persistent hypertension is one of the risk factors for strokes, heart attacks, heart failure and arterial aneurysms, and is the leading cause of chronic kidney failure. Even moderate elevation of arterial pressure leads to shortened life expectancy. At severely high pressures, mean arterial pressures 50% or more above average, a person can expect to live no more than a few years unless appropriately treated.Textbook of Medical Physiology, 7th Ed., Guyton & Hall, Elsevier-Saunders, {{ISBN|0-7216-0240-1}}, p. 220.In the past, most attention was paid to diastolic pressure; but nowadays it is recognized that both high systolic pressure and high pulse pressure (the numerical difference between systolic and diastolic pressures) are also risk factors. In some cases, it appears that a decrease in excessive diastolic pressure can actually increase risk, due probably to the increased difference between systolic and diastolic pressures (see the article on pulse pressure). If systolic blood pressure is elevated (>140 mmHg) with a normal diastolic blood pressure (20/10 mm Hg) is termed orthostatic hypotension (postural hypotension) and represents a failure of the body to compensate for the effect of gravity on the circulation. Standing results in an increased hydrostatic pressure in the blood vessels of the lower limbs. The consequent distension of the veins below the diaphragm (venous pooling) causes ~500 ml of blood to be relocated from the chest and upper body. This results in a rapid decrease in central blood volume and a reduction of ventricular preload which in turn reduces stroke volume, and mean arterial pressure. Normally this is compensated for by multiple mechanisms, including activation of the autonomic nervous system which increases heart rate, myocardial contractility and systemic arterial vasoconstriction to preserve blood pressure and elicits venous vasoconstriction to decrease venous compliance. Decreased venous compliance also results from an intrinsic myogenic increase in venous smooth muscle tone in response to the elevated pressure in the veins of the lower body. Other compensatory mechanisms include the veno-arteriolar axon reflex, the 'skeletal muscle pump' and 'respiratory pump'. Together these mechanisms normally stabilize blood pressure within a minute or less.JOURNAL, 2015-08-18, Orthostatic Hypotension: Epidemiology, Prognosis, and Treatment, Journal of the American College of Cardiology, en, 66, 7, 848–860, 10.1016/j.jacc.2015.06.1084, 26271068, 0735-1097, Ricci, Fabrizio, De Caterina, Raffaele, Fedorowski, Artur, If these compensatory mechanisms fail and arterial pressure and blood flow decrease beyond a certain point, the perfusion of the brain becomes critically compromised (i.e., the blood supply is not sufficient), causing lightheadedness, dizziness, weakness or fainting.JOURNAL, Franco Folino A, Cerebral autoregulation and syncope, Prog Cardiovasc Dis, 50, 1, 49–80, 2007, 17631437, 10.1016/j.pcad.2007.01.001, Usually this failure of compensation is due to diseases or drugs that affect the sympathetic nervous system. A similar effect is observed following the experience of excessive gravitational forces (G-loading), such as routinely experienced by aerobatic or combat pilots 'pulling Gs' where the extreme hydrostatic pressures exceed the ability of the body's compensatory mechanisms.

Fluctuating blood pressure

Normal fluctuation in blood pressure is adaptive and necessary. Fluctuations in pressure that are significantly greater than the norm are associated with greater white matter hyperintensity, a finding consistent with reduced local cerebral blood flowJOURNAL, Thomas AJ, Perry R, Barber R, Kalaria RN, O'Brien JT, Pathologies and Pathological Mechanisms for White Matter Hyperintensities in Depression, Annals of the New York Academy of Sciences, 977, 333–39, 2002, 12480770, 10.1111/j.1749-6632.2002.tb04835.x, and a heightened risk of cerebrovascular disease.JOURNAL, Brickman AM, Reitz C, Luchsinger JA, Manly JJ, Schupf N, Muraskin J, DeCarli C, Brown TR, Mayeux R, Long-term Blood Pressure Fluctuation and Cerebrovascular Disease in an Elderly Cohort, Archives of Neurology, 67, 5, 564–69, 2010, 20457955, 2917204, 10.1001/archneurol.2010.70, Within both high and low blood pressure groups, a greater degree of fluctuation was found to correlate with an increase in cerebrovascular disease compared to those with less variability, suggesting the consideration of the clinical management of blood pressure fluctuations, even among normotensive older adults. Older individuals and those who had received blood pressure medications were more likely to exhibit larger fluctuations in pressure.


(File:Systolevs Diastole.png|thumb|Cardiac systole and diastole)During each heartbeat, blood pressure varies between a maximum (systolic) and a minimum (diastolic) pressure.WEB,weblink Normal Blood Pressure Range Adults, Health and Life, 2010-06-07, 2010-06-20,weblink" title="">weblink 2016-03-18, yes, The blood pressure in the circulation is principally due to the pumping action of the heart.BOOK, Caro, Colin G., vanc, The Mechanics of The Circulation, Oxford University Press, Oxford [Oxfordshire], 1978, 978-0-19-263323-1, Differences in mean blood pressure drive the flow of blood around the circulation. The rate of mean blood flow depends on both blood pressure and the resistance to flow presented by the blood vessels. In the absence of hydrostatic effects (e.g. standing), mean blood pressure decreases as the circulating blood moves away from the heart through arteries and capillaries due to viscous losses of energy. Mean blood pressure drops over the whole circulation, although most of the fall occurs along the small arteries and arterioles.BOOK, Klabunde, Richard, Cardiovascular Physiology Concepts, Lippincott Williams & Wilkins, 2005, 93–94, 978-0-7817-5030-1, Pulsatility also diminishes in the smaller elements of the arterial circulation, although some transmitted pulsatility is observed in capillaries.JOURNAL, Mahler, F., Muheim, M. H., Intaglietta, M., Bollinger, A., Anliker, M., 1979, Blood pressure fluctuations in human nailfold capillaries, The American Journal of Physiology, 236, 6, H888–893, 10.1152/ajpheart.1979.236.6.H888, 0002-9513, 443454, (File:Circulation pressures v1.tif|thumb|Schematic of pressures in the circulation) Gravity affects blood pressure via hydrostatic forces (e.g., during standing), and valves in veins, breathing, and pumping from contraction of skeletal muscles also influence blood pressure, particularly in veins.


A simple view of the hemodynamics of systemic arterial pressure is based around mean arterial pressure (MAP) and pulse pressure. Most influences on blood pressure can be understood in terms of their effect on cardiac outputJOURNAL, Guyton AC, December 1981, The relationship of cardiac output and arterial pressure control, Circulation, 64, 6, 1079–88, 10.1161/01.cir.64.6.1079, 6794930, and systemic vascular resistance. Cardiac output is the product of stroke volume and heart rate, and stroke volume is influenced by blood volume. In the short-term, the greater the blood volume, the higher the cardiac output. This may explain in part the relationship between dietary salt intake and increased blood pressure, where increased salt intake may increase blood volume potentially resulting in higher arterial pressure. However, this varies with the individual and is highly dependent on autonomic nervous system response and the renin–angiotensin system.JOURNAL, Freis ED, April 1976, Salt, volume and the prevention of hypertension, Circulation, 53, 4, 589–95, 10.1161/01.CIR.53.4.589, 767020, JOURNAL, Caplea A, Seachrist D, Dunphy G, Ely D, April 2001, Sodium-induced rise in blood pressure is suppressed by androgen receptor blockade, American Journal of Physiology. Heart and Circulatory Physiology, 4, 280, 4, H1793–801, 10.1152/ajpheart.2001.280.4.H1793, 11247793, JOURNAL, Houston MC, January 1986, Sodium and hypertension. A review, Archives of Internal Medicine, 1, 146, 1, 179–85, 10.1001/archinte.1986.00360130217028, 3510595, In the longer-term the relationship between volume and blood pressure is more complex.JOURNAL, Titze, Jens, Luft, Friedrich C., 2017, Speculations on salt and the genesis of arterial hypertension, Kidney International, 91, 6, 1324–1335, 10.1016/j.kint.2017.02.034, 1523-1755, 28501304, In simple terms systemic vascular resistance is mainly determined by the caliber of small arteries and arterioles. The resistance attributable to a blood vessel depends on its radius as described by the Hagen-Poiseuille's equation (resistance∝1/radius4). Hence, the smaller the radius, the very much higher the resistance. Other physical factors that affect resistance include: vessel length (the longer the vessel, the higher the resistance), blood viscosity (the higher the viscosity, the higher the resistance)JOURNAL, Lee AJ, December 1997, The role of rheological and haemostatic factors in hypertension, Journal of Human Hypertension, 11, 12, 767–76, 10.1038/sj.jhh.1000556, 9468002, and the number of vessels, particularly the smaller numerous, arterioles and capillaries. The presence of an arterial stenosis increases resistance to flow, however this increase in resistance rarely increases systemic blood pressure because its contribution to total systemic resistance is small, although it may profoundly decrease downstream flow.JOURNAL, Coffman JD, December 1988, Pathophysiology of obstructive arterial disease, Herz, 13, 6, 343–50, 3061915, Substances called vasoconstrictors reduce the caliber of blood vessels, thereby increasing blood pressure. Vasodilators (such as nitroglycerin) increase the caliber of blood vessels, thereby decreasing arterial pressure. In the longer term a process termed remodeling also contributes to changing the caliber of small blood vessels and influencing resistance and reactivity to vasoactive agents.JOURNAL, Korner, P. I., Angus, J. A., 1992, Structural determinants of vascular resistance properties in hypertension. Haemodynamic and model analysis, Journal of Vascular Research, 29, 4, 293–312, 10.1159/000158945, 1018-1172, 1391553, JOURNAL, Mulvany, Michael J., 2012, Small artery remodelling in hypertension, Basic & Clinical Pharmacology & Toxicology, 110, 1, 49–55, 10.1111/j.1742-7843.2011.00758.x, 1742-7843, 21733124, Reductions in capillary density, termed capillary rarefaction, may also contribute to increased resistance in some circumstances.JOURNAL, de Moraes, Roger, Tibirica, Eduardo, 2017, Early Functional and Structural Microvascular Changes in Hypertension Related to Aging, Current Hypertension Reviews, 13, 1, 24–32, 10.2174/1573402113666170413095508, 1875-6506, 28412915, In practice, each individual's autonomic nervous system and other systems regulating blood pressure, notably the kidney,JOURNAL, Norman, Roger A., Manning, R. Davis, Scheel, Konrad W., Cowley, Allen W., Coleman, Thomas G., Guyton, Arthur C., 1972-05-01, Arterial pressure regulation: Overriding dominance of the kidneys in long-term regulation and in hypertension,weblink The American Journal of Medicine, English, 52, 5, 584–594, 10.1016/0002-9343(72)90050-2, 1555-7162, respond to and regulate all these factors so that, although the above issues are important, they rarely act in isolation and the actual arterial pressure response of a given individual can vary widely in the short and long term.

Mean arterial pressure

MAP is the average of blood pressure over a cardiac cycle and is determined by the cardiac output (CO), systemic vascular resistance (SVR), and central venous pressure (CVP)):JOURNAL, Mayet, J, Hughes, A, Cardiac and vascular pathophysiology in hypertension., Heart (British Cardiac Society), 89, 9, 2003, 1355-6037, 12923045, 1767863, 1104–9, BOOK, Granger, Joey P., Hall, John E., Comprehensive Hypertension, Role of the Kidney in Hypertension, Elsevier, 2007, 978-0-323-03961-1, 10.1016/b978-0-323-03961-1.50026-x, 241–263, WEB,weblink Cardiovascular Physiology Concepts – Mean Arterial Pressure, 2008-09-29, Klabunde RE, 2007, yes,weblink 2009-10-04,
! text{MAP} = (text{CO} cdot text{SVR}) + text{CVP}
In practice, the contribution of CVP (which is small) is generally ignored and so
! text{MAP} = text{CO} cdot text{SVR}
MAP can be estimated from measurements of the systolic pressure ! P_{text{sys}}  and the diastolic pressure ! P_{text{dias}} 
! text{MAP} approxeq P_{text{dias}} + frac{1}{3} (P_{text{sys}} - P_{text{dias}})

Pulse pressure

(File:Arterial-blood-pressure-curve.svg|thumb|A schematic representation of the arterial pressure waveform over one cardiac cycle. The notch in the curve is associated with closing of the aortic valve.)The pulse pressure is the difference between the measured systolic and diastolic pressures,
! P_{text{pulse}} = P_{text{sys}} - P_{text{dias}}.
The pulse pressure is a consequence of the pulsatile nature of the cardiac output, i.e. the heartbeat. The magnitude of the pulse pressure is usually attributed to the interaction of the stroke volume of the heart, the compliance (ability to expand) of the arterial system—largely attributable to the aorta and large elastic arteries—and the resistance to flow in the arterial tree.WEB,weblink Cardiovascular Physiology Concepts – Pulse Pressure, 2008-10-02, Klabunde RE, 2007, yes,weblink 2009-10-04,

Regulation of blood pressure

The endogenous regulation of arterial pressure is not completely understood, but the following mechanisms of regulating arterial pressure have been well-characterized: These different mechanisms are not necessarily independent of each other, as indicated by the link between the RAS and aldosterone release. When blood pressure falls many physiological cascades commence in order to return the blood pressure to a more appropriate level.
  1. The blood pressure fall is detected by a decrease in blood flow and thus a decrease in glomerular filtration rate (GFR).
  2. Decrease in GFR is sensed as a decrease in Na+ levels by the macula densa.
  3. The macula densa causes an increase in Na+ reabsorption, which causes water to follow in via osmosis and leads to an ultimate increase in plasma volume. Further, the macula densa releases adenosine which causes constriction of the afferent arterioles.
  4. At the same time, the juxtaglomerular cells sense the decrease in blood pressure and release renin.
  5. Renin converts angiotensinogen (inactive form) to angiotensin I (active form).
  6. Angiotensin I flows in the bloodstream until it reaches the capillaries of the lungs where angiotensin converting enzyme (ACE) acts on it to convert it into angiotensin II.
  7. Angiotensin II is a vasoconstrictor which will increase blood flow to the heart and subsequently the preload, ultimately increasing the cardiac output.
  8. Angiotensin II also causes an increase in the release of aldosterone from the adrenal glands.
  9. Aldosterone further increases the Na+ and H2O reabsorption in the distal convoluted tubule of the nephron.
Currently, the RAS is targeted pharmacologically by ACE inhibitors and angiotensin II receptor antagonists, also known as angiotensin receptor blockers (ARBs). The aldosterone system is directly targeted by spironolactone, an aldosterone antagonist. The fluid retention may be targeted by diuretics; the antihypertensive effect of diuretics is due to its effect on blood volume. Generally, the baroreceptor reflex is not targeted in hypertension because if blocked, individuals may suffer from orthostatic hypotension and fainting.


(File:Blood Pressure - Take Another Person.png|thumb|Taking blood pressure with a sphygmomanometer)Arterial pressure is most commonly measured via a sphygmomanometer, which uses the height of a column of mercury, or an aneroid gauge, to reflect the blood pressure by auscultation.JOURNAL, Booth J, A short history of blood pressure measurement, Proceedings of the Royal Society of Medicine, 70, 11, 793–9, November 1977, 341169, 1543468, The most common automated blood pressure measurement technique is based on the oscillometric method.JOURNAL, Forouzanfar M, Dajani HR, Groza VZ, Bolic M, Rajan S, Batkin I, Oscillometric Blood Pressure Estimation: Past, Present, and Future, IEEE Reviews in Biomedical Engineering, 8, 44–63, 2015-01-01, 25993705, 10.1109/RBME.2015.2434215, Fully automated oscillometric measurement has been available since 1981.Google patents: Donald Nunn—Apparatus and method for measuring blood pressure This principle has recently been used to measure blood pressure with a smartphone.JOURNAL, Chandrasekhar A, Kim CS, Naji M, Natarajan K, Hahn JO, Mukkamala R, Smartphone-based blood pressure monitoring via the oscillometric finger-pressing method, Science Translational Medicine, 10, 431, eaap8674, March 2018, 29515001, 6039119, 10.1126/scitranslmed.aap8674, Measuring pressure invasively, by penetrating the arterial wall to take the measurement, is much less common and usually restricted to a hospital setting.Novel methods to measure blood pressure without penetrating the arterial wall, and without applying any pressure on patient's body are currently being explored. So-called cuffless measurements, these methods open the door to more comfortable and acceptable blood pressure monitors. See by instance, a cuffless blood pressure monitor at the wrist that uses only optical sensors JOURNAL, Sola J, Bertschi M, Krauss J, Measuring Pressure: Introducing oBPM, the Optical Revolution for Blood Pressure Monitoring, IEEE Pulse, 9, 5, September 2018, 10.1109/MPUL.2018.2856960,

Blood pressure in other animals

Blood pressure in non-human mammals is similar to human blood pressure. In contrast, heart rate differs markedly, largely depending on the size of the animal (larger animals have slower heart rates).BOOK, The design of mammals : a scaling approach, John William, Prothero, vanc, 9781107110472, Cambridge, 907295832, 2015-10-22, As in humans, blood pressure in animals differs by age, sex, time of day and circumstances:BOOK, Animal models in cardiovascular research, Gross, David R., vanc, Springer, 2009, 9780387959627, 3rd, Dordrecht, 5, 432709394, JOURNAL, Brown S, Atkins C, Bagley R, Carr A, Cowgill L, Davidson M, Egner B, Elliott J, Henik R, Labato M, Littman M, Polzin D, Ross L, Snyder P, Stepien R, Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats, Journal of Veterinary Internal Medicine, 21, 3, 542–58, 2007, 17552466, 10.1111/j.1939-1676.2007.tb03005.x, measurements made in laboratories or anesthesia may not be representative of values under free-living conditions. Rats, mice, dogs and rabbits have been used extensively to study the causes of high blood pressure.JOURNAL, Lerman LO, Chade AR, Sica V, Napoli C, Animal models of hypertension: an overview, The Journal of Laboratory and Clinical Medicine, 146, 3, 160–73, September 2005, 16131455, 10.1016/j.lab.2005.05.005, {| class="wikitable"|+Blood pressure and heart rate of various mammals (modified from )!Species!Systolic blood pressure, mm Hg !Diastolic blood pressure, mm Hg!Heart rate, beats per minute|Calves|140|70|75–146|Cats|155|68|100–259|Dogs|161|51|62–170|Goats|140|90|80–120|Guinea-pigs|140|90|240–300|Mice|120|75|580–680|Pigs|169|55|74–116|Rabbits|118|67|205–306|Rats|153|51|305–500|Rhesus monkeys|160|125|180–210|Sheep|140|80|63–210

Hypertension in cats and dogs

Hypertension in cats and dogs is diagnosed if the blood pressure is greater than 150 mm Hg (systolic) and/or 95 mm Hg (diastolic).



Further reading

  • JOURNAL, Pickering TG, Hall JE, Appel LJ, Falkner BE, Graves J, Hill MN, Jones DW, Kurtz T, Sheps SG, Roccella EJ, Recommendations for blood pressure measurement in humans and experimental animals: Part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research, Hypertension, 45, 5, 142–61, 2005, 15611362, 10.1161/01.HYP.0000150859.47929.8e, Subcommittee of Professional Public Education of the American Heart Association Council on High Blood Pressure Research,

External links

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